Patents Assigned to Kane Biotech Inc.
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Patent number: 11723852Abstract: Compositions comprising one or more chelating agents and optionally zinc ion salts are used to inhibit the growth or biofilm formation in bacteria associated with personal care products such as ophthalmic, pedicure, manicure or podiatric solutions. The compositions of the present application can also comprise gelling agents, antimicrobials, antibiotic or a pH adjuster. The compositions may be in the form of a solution, a gel, a cream, a jelly, a powder, a paste, a lotion, soap and a cleaner.Type: GrantFiled: August 3, 2021Date of Patent: August 15, 2023Assignee: KANE BIOTECH INC.Inventors: Purushottam V. Gawande, Karen Lovetri, Nandadeva Yakandawala, Gord Froehlich, Srinivasa Madhyastha
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Patent number: 11103433Abstract: Compositions comprising one or more chelating agents and optionally zinc ion salts are used to inhibit the growth or biofilm formation in bacteria associated with personal care products such as ophthalmic, pedicure, manicure or podiatric solutions. The compositions of the present application can also comprise gelling agents, antimicrobials, antibiotic or a pH adjuster. The compositions may be in the form of a solution, a gel, a cream, a jelly, a powder, a paste, a lotion, soap and a cleaner.Type: GrantFiled: June 26, 2015Date of Patent: August 31, 2021Assignee: KANE BIOTECH INC.Inventors: Purushottam V. Gawande, Karen Lovetri, Nandadeva Yakandawala, Gord Froehlich, Srinivasa Madhyastha
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Patent number: 11090366Abstract: Compositions comprising iron-sequestering glycoproteins, chelating agents, stabilizing agents, binding agents, surfactants, fluorides, antimicrobials and a pH adjuster or buffer for the prevention and treatment of oral cavity diseases caused by dental plaque/biofilm, such as dental caries, gingivitis and periodontitis, through anti-infective properties are disclosed. The anti-infective properties of a composition include reduction or killing of anaerobic/aerobic/facultative gram-negative and gram-positive oral bacteria occurring in polymicrobial dental biofilms. The composition may be in the form of wash, rinse, soak, paste, gel, spray, or other suitable form. Additionally, the invention offers an efficient method of delivering the formulated composition containing a PEGylated or fluorinated iron-sequestering glycoprotein and one or two chelating agents or chelating agents alone using either a liposomal or a nanoparticle delivery system.Type: GrantFiled: June 27, 2012Date of Patent: August 17, 2021Assignee: Kane Biotech Inc.Inventors: Karen LoVetri, Srinivasa Madhyastha, Nandadeva Yakandawala, Purushottam V. Gawande, Gord Froehlich
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Patent number: 10357470Abstract: Compositions comprising chelating agents, metal ion salts, gelling agents or a buffer, antimicrobials, antibiofilm agents and a pH adjuster or a buffer for the prevention and treatment of wound infections and food-borne diseases involving bacterial biofilms are disclosed. The anti-infective properties of a composition include reduction or killing of anaerobic/aerobic/facultative gram-negative and gram-positive wound infection associated bacteria occurring in polymicrobial biofilms. The composition may be in the form of lotion, cream, ointment, dressing, bandage, rinse, soak, gel, spray, or other suitable forms, including certain devices. Additionally, the invention offers an efficient method of delivering the formulated composition containing one or two chelating agents or chelating agents alone or in combination with a metal ion salt using either a nanoparticle or other efficient delivery systems.Type: GrantFiled: July 18, 2017Date of Patent: July 23, 2019Assignee: KANE BIOTECH INC.Inventors: Purushottam V. Gawande, Karen Lovetri, Nandadeva Yakandawala, Gordon Froehlich, Srinivasa Madhyastha
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Patent number: 9980497Abstract: Compositions comprising chelating agents, metal ion salts, gelling agents or a buffer, antimicrobials, antibiofilm agents and a pH adjuster or a buffer for the prevention and treatment of wound infections and food-borne diseases involving bacterial biofilms are disclosed. The anti-infective properties of a composition include reduction or killing of anaerobic/aerobic/facultative gram-negative and gram-positive wound infection associated bacteria occurring in polymicrobial biofilms. The composition may be in the form of lotion, cream, ointment, dressing, bandage, rinse, soak, gel, spray, or other suitable forms, including certain devices. Additionally, the invention offers an efficient method of delivering the formulated composition containing one or two chelating agents or chelating agents alone or in combination with a metal ion salt using either a nanoparticle or other efficient delivery systems.Type: GrantFiled: March 6, 2014Date of Patent: May 29, 2018Assignee: KANE BIOTECH, INC.Inventors: Purushottam V. Gawande, Karen Lovetri, Nandadeva Yakandawala, Gordon Froelich, Srinivasa Madhyastha
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Patent number: 9936712Abstract: Compositions comprising chelating agents, metal ion salts, gelling agents or a buffer, antimicrobials, antibiofilm agents and a pH adjuster or a buffer for the prevention and treatment of wound infections and food-borne diseases involving bacterial biofilms are disclosed. The anti-infective properties of a composition include reduction or killing of anaerobic/aerobic/facultative gram-negative and gram-positive wound infection associated bacteria occurring in polymicrobial biofilms. The composition may be in the form of lotion, cream, ointment, dressing, bandage, rinse, soak, gel, spray, or other suitable forms, including certain devices. Additionally, the invention offers an efficient method of delivering the formulated composition containing one or two chelating agents or chelating agents alone or in combination with a metal ion salt using either a nanoparticle or other efficient delivery systems.Type: GrantFiled: March 6, 2014Date of Patent: April 10, 2018Assignee: KANE BIOTECH, INC.Inventors: Purushottam V. Gawande, Karen Lovetri, Nandadeva Yakandawala, Gordon Froelich, Srinivasa Madhyastha
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Patent number: 9622481Abstract: The present invention provides novel compositions comprising: (a) a metaperiodate and (b) chlorhexidine or a chlorohexidine salt and uses thereof for the preparation of devices, and in particular medical devices, susceptible to colonization by biofilm forming bacteria.Type: GrantFiled: May 1, 2014Date of Patent: April 18, 2017Assignee: Kane Biotech Inc.Inventors: Purushottam Gawande, Srinivasa Madhyastha, Karen Lovetri, Nandadeva Yakandawala, Gord Froehlich
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Patent number: 8906364Abstract: The present invention provides compositions for preventing growth and proliferation of biofilm embedded microorganisms on devices comprising: (a) a cationic polypeptide and (b) a bis-guanide or a salt thereof. The invention further provides methods for preparing medical devices with such compositions.Type: GrantFiled: January 11, 2006Date of Patent: December 9, 2014Assignee: Kane Biotech Inc.Inventor: Srinivasa Madhyastha
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Publication number: 20140322351Abstract: The present invention provides novel compositions comprising: (a) a metaperiodate and (b) chlorhexidine or a chlorohexidine salt and uses thereof for the preparation of devices, and in particular medical devices, susceptible to colonization by biofilm forming bacteria.Type: ApplicationFiled: May 1, 2014Publication date: October 30, 2014Applicant: Kane Biotech Inc.Inventors: Purushottam GAWANDE, Srinivasa MADHYASTHA, Karen LOVETRI, Nandadeva YAKANDAWALA, Gord FROEHLICH
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Patent number: 8821862Abstract: The present invention provides compositions comprising an antibiofilm enzyme, a soluble ?-N-acetylglucosaminidase similar to the dspB gene (DispersinB®), and an antimicrobial for preventing growth and proliferation of biofilm-embedded microorganisms in acute and chronic wounds, and methods of treatment. The invention further provides methods for preparing medical devices, and in particular, wound care devices using soluble ?-N-acetylglucosaminidase based antimicrobial compositions.Type: GrantFiled: March 9, 2012Date of Patent: September 2, 2014Assignees: Kane Biotech Inc., University of Medicine and Dentistry of New JerseyInventors: Srinivasa Madhyastha, Nanda Yakandawala, Purushottam V. Gawande, Karen Lovetri, Jeffrey B. Kaplan, Daniel Rhoads, Lasha Gogokhia
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Patent number: 8753692Abstract: The present invention provides novel compositions comprising: (a) protamine sulfate and (b) benzalkonium chloride or a silver containing particle; or (a) sodium metaperiodate and (b) 5-fluorouracil or chlorhexidine and uses thereof for the preparation of devices, and in particular medical devices, susceptible to colonization by biofilm forming bacteria.Type: GrantFiled: January 22, 2010Date of Patent: June 17, 2014Assignee: Kane Biotech Inc.Inventors: Purushottam V. Gawande, Srinivasa Madhyastha, Karen Lovetri, Nandadeva Yakandawala, Gord Froehlich
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Patent number: 8617542Abstract: The present invention provides antibiofilm composition comprising two or more agents selected from the group consisting of DispersinB™, 5-Fluorouracil, Deoxyribonuclease I and Proteinase K for preventing growth and proliferation of biofilm-embedded microorganisms in wound care, oral care, and disease-related infections and methods of treatment in mammals. The invention further provides methods for preparing medical devices, and wound care devices using an antibiofilm composition comprising two or more antimicrobial agents selected from the group consisting of DispersinB™, 5-Fluorouracil, Deoxyribonuclease I and Proteinase K.Type: GrantFiled: April 3, 2009Date of Patent: December 31, 2013Assignee: Kane Biotech Inc.Inventors: Srinivasa Madhyastha, Purusbottam Gawande, Karen Lovetri, Nandadeva Yakandawala, Jeffrey Kaplan
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Publication number: 20120258089Abstract: The present invention provides compositions comprising an antibiofilm enzyme, a soluble ?-N-acetylglucosaminidase similar to the dspB gene (DispersinB®), and an antimicrobial for preventing growth and proliferation of biofilm-embedded microorganisms in acute and chronic wounds, and methods of treatment. The invention further provides methods for preparing medical devices, and in particular, wound care devices using soluble ?-N-acetylglucosaminidase based antimicrobial compositions.Type: ApplicationFiled: March 9, 2012Publication date: October 11, 2012Applicant: Kane Biotech Inc.Inventors: Srinivasa MADHYASTHA, Nanda Yakandawala, Purushottam V. Gawande, Karen Lovetri, Jeffrey B. Kaplan, Daniel Rhoads, Lasha Gogokhia
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Publication number: 20110311647Abstract: The present invention provides novel compositions comprising: (a) protamine sulfate and (b) benzalkonium chloride or a silver containing particle; or (a) sodium metaperiodate and (b) 5-fluorouracil or chlorhexidine and uses thereof for the preparation of devices, and in particular medical devices, susceptible to colonization by biofilm forming bacteria.Type: ApplicationFiled: January 22, 2010Publication date: December 22, 2011Applicant: Kane Biotech Inc.Inventors: Purushottam V. Gawande, Srinivasa Madhyastha, Karen Lovetri, Nandadeva Yakandawala, Gord Froehlich
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Publication number: 20110008402Abstract: The present invention provides compositions comprising an antibiofilm enzyme, a soluble ?-N-acetylglucosaminidase similar to the dspB gene (DispersinB™), and an antimicrobial for preventing growth and proliferation of biofilm-embedded microorganisms in acute and chronic wounds, and methods of treatment. The invention further provides methods for preparing medical devices, and in particular, wound care devices using DispersinB™-based antimicrobial compositions.Type: ApplicationFiled: October 12, 2007Publication date: January 13, 2011Applicant: Kane Biotech Inc.Inventors: Srinivasa Madhyastha, Nanda Yakandawala, Purushottam V. Gawande, Karen Lovetri, Jeffrey B. Kaplan, Daniel Rhoads, Lasha Gogokhia
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Publication number: 20100221308Abstract: The present invention includes compositions for preventing growth and proliferation of biofilm embedded microorganisms comprising: (a) a cationic polypeptide and (b) a bis-gaunide or a salt thereof. The invention further provides methods for preparing objects with such compositions, and objects and consumables (such as household cleaners) comprising such compositions.Type: ApplicationFiled: May 12, 2010Publication date: September 2, 2010Applicant: KANE BIOTECH INC.Inventors: SRINIVASA MADHYASTHA, PURUSHOTTAM GAWANDE, KAREN LOVETRI
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Patent number: 7556807Abstract: Peptide analogues of S. mutans CSP peptide which inhibit biofilm formation, uses thereof in the preparation of pharmaceutical compositions, antimicrobial compositions and uses thereof in the treatment and prevention of infections caused by biofilm forming bacteria, dental plaque formation, and conditions caused by dental plaque associated bacteria are provided.Type: GrantFiled: July 28, 2005Date of Patent: July 7, 2009Assignees: Kane Biotech, Inc., The Governing Council of the University of TorontoInventors: Dennis Cvitkovitch, Srinivasa Madhyastha
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Patent number: 7314857Abstract: A synergistic antimicrobial composition for inhibiting biofilm formation includes an iron-sequestering glycoprotein, a cationic polypeptide and a chelating agent, or an iron-sequestering glycoprotein and a chelating agent, or an iron-sequestering glycoprotein and a cationic polypeptide. Additionally, surfactants and quaternary ammonium compounds may also be advantageously combined with iron-sequestering glycoproteins in an antimicrobial composition. Methods of using a synergistic composition for inhibiting medical device biofilm formation are also disclosed.Type: GrantFiled: February 17, 2004Date of Patent: January 1, 2008Assignee: Kane Biotech Inc.Inventor: Srinivasa Madhyastha
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Patent number: 7144992Abstract: The present invention provides novel compositions comprising: (a) a thiol-specific reagent and a cationic polypeptide or (b) a thiol-specific reagent and an iron-sequestering glyocoprotein; and uses thereof for the preparation of devices, and in particular medical devices, susceptible to colonization by biofilm forming bacteria.Type: GrantFiled: April 16, 2004Date of Patent: December 5, 2006Assignee: Kane Biotech Inc.Inventor: Srinivasa Madhyastha
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Publication number: 20050049181Abstract: A synergistic antimicrobial composition for inhibiting biofilm formation includes an iron-sequestering glycoprotein, a cationic polypeptide and a chelating agent, or an iron-sequestering glycoprotein and a chelating agent, or an iron-sequestering glycoprotein and a cationic polypeptide. Additionally, surfactants and quaternary ammonium compounds may also be advantageously combined with iron-sequestering glycoproteins in an antimicrobial composition. Methods of using a synergistic composition for inhibiting medical device biofilm formation are also disclosed.Type: ApplicationFiled: February 17, 2004Publication date: March 3, 2005Applicant: KANE BIOTECH INC.Inventor: Srinivasa Madhyastha