Abstract: Disclosed is a method of measuring protein kinase activity, including a) attaching GMBS (N-[?-maleimidobutyryloxy]sulfosuccinimide ester) to a base plate, b) attaching a substrate that reacts with a protein kinase to the base plate having GMBS attached thereto, thus manufacturing a kit for measuring protein kinase activity, c) introducing, to the kit, a mixture of a sample to be analyzed and a buffer including triton X-100, and d) probing phosphorylation of the substrate caused by the protein kinase contained in the sample, thereby measuring the activity of the protein kinase.

Abstract: The present invention provides a pharmaceutical composition for preventing or treating Alzheimer's disease and a food composition for relieving symptoms of Alzheimer's disease, which comprise a mountain-cultivated ginseng extract. The composition comprising the mountain-cultivated ginseng extract of the present invention is beneficially used as a pharmaceutical composition for preventing or treating Alzheimer's disease in the medical field for the treatment of Alzheimer's disease or as a food composition for relieving the symptoms of Alzheimer's disease.

Abstract: A device for in vitro culture of embryos includes: an array having at least one well formed therein; and a bottom surface formed in the well and made of polydimethylsiloxane (PDMS). The use of the culture vessel having the well bottom surface made of PDMS has the effect of further increasing the blastocyst formation rate of embryos compared to the use of conventional arrays made of plastic.

Abstract: Disclosed is a composition for the prevention or treatment of diabetic complications, containing a benzodiazepine-based compound, thereby effectively preventing or treating diseases resulting from hyperglycemia, which is the leading cause of diabetes, especially diseases caused by vascular leakage.

Abstract: The present invention relates to an apparatus for manufacturing fiber-reinforced concrete through shooting after inserting bubbles into normal concrete and a method for manufacturing the same, which: form fiber-mixed concrete in which the bubbles, fiber-mixed materials, and silica fume are mixed in the normal concrete or form the fiber-mixed concrete in which aggregates, water, and the bubbles are put into and mixed with a mixture, in which cement, the fiber-mixed materials, and silica fume are mixed; and then shoots the fiber-reinforced concrete in which excessive air included in the fiber-mixed concrete is reduced by spraying the fiber-mixed concrete with the high-pressure air when the fiber-mixed concrete is discharged, and of which a slump, drastically increased due to the large amount of bubbles, is reduced to a range of the slump of the normal concrete, thereby improving the production capacity of the fiber-reinforced concrete and shortening operating time.

Abstract: A microchip includes a first chamber and second chamber formed to a predetermined depth in a member made of polydimethylsiloxane (PDMS); and a channel (microchannel) connecting the first chamber to the second chamber. These components mimic in vivo organs which produce by selecting capacitated motile sperm from semen and causing the selected sperm to meet mature oocyte, and these components are capable of effectively producing motile capacitated good-quality sperms from sperms ejaculated outside the body.

Abstract: Disclosed is a variable-size sampling method under a data-streaming environment, including: calculating a maximum window size that satisfies a lower limitation of a predetermined uniformity confidence level at all times; inputting a data stream to be sampled; comparing a data stream length input until a current time point with the maximum window size; inspecting a sample size and a sampling fraction if the maximum window size is larger than the data stream length; performing sampling by generating a slot to increase the sample size if the current sample size is smaller than a predetermined percentage (P %) of the data stream; and directly performing sampling without generating a slot if the current sample size is equal to or larger than the predetermined percentage (P %) of the data stream. As a result, degradation of uniformity confidence during variable-size sampling under a real-time streaming environment can be prevented to improve sampling performance.

Abstract: The present disclosure relates to a method for cultivating coffee bean with improved growth and contents of nutritional ingredients, including: (a) a step of preparing diluted deep sea water by mixing undiluted deep sea water with water; and (b) a step of irrigating coffee tree with the diluted deep sea water prepared in the step (a), coffee bean with improved growth and contents of nutritional ingredients, cultivated by the method, and a processed food using the coffee bean.

Abstract: Disclosed is a method of preparing ezetimibe, including cross-metathesis using a Grubbs 2nd catalyst and deprotection using a Pearlman's catalyst, and an intermediate thereof. The method of preparing ezetimibe is useful as an efficient ezetimibe synthesis technique in pharmaceutical fields using ezetimibe as a raw material.

Abstract: Disclosed is a method of producing high-purity lithium carbonate and barium sulfate from discarded lithium secondary batteries, including: a first process for producing high-purity lithium phosphate from a discarded battery; and a second process for producing lithium sulfate from the lithium phosphate and producing lithium carbonate and barium sulfate from the lithium sulfate.

Abstract: Disclosed is a method of preparing ezetimibe, including cross-metathesis using a Grubbs 2nd catalyst and deprotection using a Pearlman's catalyst, and an intermediate thereof. The method of preparing ezetimibe is useful as an efficient ezetimibe synthesis technique in pharmaceutical fields using ezetimibe as a raw material.

Abstract: Disclosed is a composition for the prevention or treatment of diabetic complications, containing a benzodiazepine-based compound, thereby effectively preventing or treating diseases resulting from hyperglycemia, which is the leading cause of diabetes, especially diseases caused by vascular leakage.

Abstract: Disclosed is a method of producing high-purity lithium carbonate from low-purity crude lithium carbonate.

Abstract: A microchip includes a first chamber and second chamber formed to a predetermined depth in a member made of polydimethylsiloxane (PDMS); and a channel (microchannel) connecting the first chamber to the second chamber. These components mimic in vivo organs which produce by selecting capacitated motile sperm from semen and causing the selected sperm to meet mature oocyte, and these components are capable of effectively producing motile capacitated good-quality sperms from sperms ejaculated outside the body.

Abstract: A device for in vitro culture of embryos includes: an array having at least one well formed therein; and a bottom surface formed in the well and made of polydimethylsiloxane (PDMS). The use of the culture vessel having the well bottom surface made of PDMS has the effect of further increasing the blastocyst formation rate of embryos compared to the use of conventional arrays made of plastic.

Abstract: The present invention relates to an apparatus for producing rapid-hardening concrete and a method for producing same, the rapid-hardening concrete being produced by intermixing and dissipating air in normal concrete and adding an early-strength admixture thereto. With respect to forming rapid-hardening concrete, mixed concrete is formed by mixing in a large volume of air bubbles to be discarded, along with an early-strength admixture, to already mixed normal concrete, the early-strength admixture getting evenly dispersed therewithin by means of the ball bearing effect of the air bubbles, and when the mixed concrete is discharged, a rapid-hardening concrete is shotcreted while excess air contained in the mixed concrete is dissipated by means of high-performance air, the slump which was raised due to the large amount of air bubbles having been reduced to the slump range for normal concrete.

Abstract: Disclosed are a pharmaceutical composition and a method for preventing or treating diabetic complications caused by vascular leakage, comprising a TGase2 inhibitor, and a method of screening a preventive or therapeutic agent for diabetic complications caused by vascular leakage.

Abstract: The present invention relates to a method for constructing a continuously reinforced concrete pavement using foam shotcrete by: positioning continuous reinforcement bars on a base layer where a concrete pavement is constructed; producing normal concrete having a compressive strength of 21-30 MPa from a batch plant and transporting same to a construction site; and shooting a normal strength concrete, which has been produced by mixing, with a mixing part, fly ash or fine slag powder or a low-grade mixed material produced by mixing the fly and the fine slag powder in a state in which fluidity has been increased by mixing in 20-40% of air bubbles with respect to volume, or shooting a high-performance concrete, which has been produced by mixing, with the mixing part, one or a mixture of two or more of silica fume, meta-kaolin, latex, polymers, and a coloring material.

Abstract: The present disclosure relates to a method for producing a monoclonal antibody that binds to an epitope for the glycan binding site of a glycoprotein. According to the present disclosure, a monoclonal antibody that recognizes the glycan binding site of a glycoprotein as an epitope can be produced in a relatively simple and economic manner, and a monoclonal antibody having high sensitivity and specificity for the glycan binding site of a glycoprotein can be produced. The monoclonal antibody produced according to the present disclosure can be effectively used as an agent for diagnosing or treating various diseases associated with a change in glycan structure or glycan expression level.

Abstract: Disclosed is an apparatus and method for manufacturing high-performance concrete by introducing air into normal concrete and dissipating air, wherein high-performance concrete is formed in a manner in which bubbles, which are to be removed, are added in a large amount together with an admixture to pre-blended normal concrete so that the admixture is uniformly dispersed in the normal concrete using the ball-bearing effect of the bubbles, thus forming mixed concrete, and the mixed concrete is discharged using air at a high pressure of 5 atom or more to thereby shoot high-performance concrete of which the slump, remarkably increased due to the large amount of bubbles, is reduced to fall within the range of slump of normal concrete while dissipating excess air from the mixed concrete.