Patents Assigned to Kansai Medical University
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Publication number: 20230293542Abstract: The present invention provides a medicament that exerts a psychotropic action through selective sensory nerve stimulation. A prophylactic or therapeutic agent for a psychiatric disorder, containing, as an active ingredient, at least one kind selected from a heterocyclic compound represented by the formula (I) wherein each symbol is as described in the specification, or a salt thereof, and an isothiocyanate compound represented by the formula S?C?N—R5 (II) wherein each symbol is as described in the specification.Type: ApplicationFiled: August 2, 2021Publication date: September 21, 2023Applicants: KANSAI MEDICAL UNIVERSITY, SCENT SCIENCE INTERNATIONAL INC.Inventors: Ko KOBAYAKAWA, Reiko KOBAYAKAWA
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Patent number: 9724300Abstract: A long-lasting, controlled-release local anesthetic liposome preparation is produced by: providing a liposome composition, which is obtained by mixing, in a water-miscible organic solvent, a first aqueous phase solution with a water-miscible organic solution, in which a phospholipid and cholesterol are contained at a defined total concentration, at a defined ratio by volume thereby obtaining an emulsion wherein a total concentration of the phospholipid and cholesterol in the mixed phase is at 15 w/v % to 50 w/v %, followed by subjecting the emulsion to external solution exchange with a second aqueous phase solution to obtain a liposome composition wherein an ion gradient is formed between an internal-region aqueous phase of a liposome membrane made of the first aqueous phase solution and an external-region aqueous phase of the liposome membrane made of the second aqueous phase solution; and encapsulating a local anesthetic in the internal-region aqueous phase according to a remote loading method.Type: GrantFiled: March 19, 2015Date of Patent: August 8, 2017Assignees: TERUMO KABUSHIKI KAISHA, KANSAI MEDICAL UNIVERSITY EDUCATIONAL CORPORATIONInventors: Keiko Yamashita, Yasuo Kurosaki, Makoto Harumoto, Kyoko Shimamura, Masaki Kaibori, Yoshiro Araki, Masanori Kon, Seiji Ito
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Patent number: 9464292Abstract: The invention relates to sense oligonucleotide having a sequence complementary to a single-stranded RNA (antisense transcript) having a sequence complementary to mRNA of iNOS gene in order to control expression of iNOS (inducible nitric oxide synthase). The sense oligonucleotide of the present invention can control expression of iNOS and is useful for biological defense and treatment and prevention of diseases related to excessive production of NO, such as cancerogenesis, inflammatory disease, endotoxin shock by bacterial infection and the like.Type: GrantFiled: December 12, 2014Date of Patent: October 11, 2016Assignees: AMINO UP CHEMICAL CO., LTD, KANSAI MEDICAL UNIVERSITYInventors: Tadayoshi Okumura, Mikio Nishizawa, Yasuo Kamiyama, Koji Wakame, Takehito Miura
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Publication number: 20150250724Abstract: A long-lasting, controlled-release local anesthetic liposome preparation is produced by: providing a liposome composition, which is obtained by mixing, in a water-miscible organic solvent, a first aqueous phase solution with a water-miscible organic solution, in which a phospholipid and cholesterol are contained at a defined total concentration, at a defined ratio by volume thereby obtaining an emulsion wherein a total concentration of the phospholipid and cholesterol in the mixed phase is at 15 w/v % to 50 w/v %, followed by subjecting the emulsion to external solution exchange with a second aqueous phase solution to obtain a liposome composition wherein an ion gradient is formed between an internal-region aqueous phase of a liposome membrane made of the first aqueous phase solution and an external-region aqueous phase of the liposome membrane made of the second aqueous phase solution; and encapsulating a local anesthetic in the internal-region aqueous phase according to a remote loading method.Type: ApplicationFiled: March 19, 2015Publication date: September 10, 2015Applicants: Kansai Medical University Educational Corporation, Terumo Kabushiki KaishaInventors: Keiko YAMASHITA, Yasuo KUROSAKI, Makoto HARUMOTO, Kyoko SHIMAMURA, Masaki KAIBORI, Yoshiro ARAKI, Masanori KON, Seiji ITO
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Publication number: 20150191733Abstract: The invention relates to sense oligonucleotide having a sequence complementary to a single-stranded RNA (antisense transcript) having a sequence complementary to mRNA of iNOS gene in order to control expression of iNOS (inducible nitric oxide synthase). The sense oligonucleotide of the present invention can control expression of iNOS and is useful for biological defense and treatment and prevention of diseases related to excessive production of NO, such as cancerogenesis, inflammatory disease, endotoxin shock by bacterial infection and the like.Type: ApplicationFiled: December 12, 2014Publication date: July 9, 2015Applicants: AMINO UP CHEMICAL CO., LTD, KANSAI MEDICAL UNIVERSITYInventors: Tadayoshi OKUMURA, Mikio NISHIZAWA, Yasuo KAMIYAMA, Koji WAKAME, Takehito MIURA
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Patent number: 8975023Abstract: The invention relates to a method of intracellularly controlling amounts of gene products, which can increase an amount of gene product intracellularly, comprising a step of introducing into the cell a substance having a sequence complementary to the base sequence of mRNA corresponding to the gene product, its precursor or another substance which can have equivalent action in the cell.Type: GrantFiled: February 19, 2013Date of Patent: March 10, 2015Assignees: Amino Up Chemical Co., Ltd, Kansai Medical UniversityInventors: Tadayoshi Okumura, Mikio Nishizawa, Yasuo Kamiyama, Koji Wakame, Takehito Miura
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Patent number: 8927704Abstract: The invention relates to sense oligonucleotide having a sequence complementary to a single-stranded RNA (antisense transcript) having a sequence complementary to mRNA of iNOS gene in order to control expression of iNOS (inducible nitric oxide synthase). The sense oligonucleotide of the present invention can control expression of iNOS and is useful for biological defense and treatment and prevention of diseases related to excessive production of NO, such as cancerogenesis, inflammatory disease, endotoxin shock by bacterial infection and the like.Type: GrantFiled: June 7, 2007Date of Patent: January 6, 2015Assignees: Amino Up Chemical Co., Ltd, Kansai Medical UniversityInventors: Tadayoshi Okumura, Mikio Nishizawa, Yasuo Kamiyama, Koji Wakame, Takehito Miura
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Publication number: 20130177909Abstract: The invention relates to a method of intracellularly controlling amounts of gene products, which can increase an amount of gene product intracellularly, comprising a step of introducing into the cell a substance having a sequence complementary to the base sequence of mRNA corresponding to the gene product, its precursor or another substance which can have equivalent action in the cell.Type: ApplicationFiled: February 19, 2013Publication date: July 11, 2013Applicants: KANSAI MEDICAL UNIVERSITY, AMINO UP CHEMICAL CO., LTD.Inventors: Tadayoshi OKUMURA, Mikio NISHIZAWA, Yasuo KAMIYAMA, Koji WAKAME, Takehito MIURA
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Patent number: 8399424Abstract: The invention relates to a method of intracellularly controlling amounts of gene products, which can increase an amount of gene product intracellularly, comprising a step of introducing into the cell a substance having a sequence complementary to the base sequence of mRNA corresponding to the gene product, its precursor or another substance which can have equivalent action in the cell.Type: GrantFiled: June 7, 2007Date of Patent: March 19, 2013Assignees: Amino Up Chemical Co., Ltd, Kansai Medical UniversityInventors: Tadayoshi Okumura, Mikio Nishizawa, Yasuo Kamiyama, Koji Wakame, Takehito Miura
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Publication number: 20120122242Abstract: A method for assessing arteriosclerosis comprising measuring the serotonin level in whole blood, serum or platelet-rich plasma and rating the serotonin level on such a scale that the lower it is, the more serious the arteriosclerosis is.Type: ApplicationFiled: January 26, 2012Publication date: May 17, 2012Applicants: KANSAI MEDICAL UNIVERSITY, TOSOH CORPOPRATIONInventors: Yuji Hirowatari, Katsuko Hara, Hakuo Takahashi
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Patent number: 8142995Abstract: A method for assessing arteriosclerosis comprising measuring the serotonin level in whole blood, serum or platelet-rich plasma and rating the serotonin level on such a scale that the lower it is, the more serious the arteriosclerosis is.Type: GrantFiled: March 11, 2008Date of Patent: March 27, 2012Assignees: Tosoh Corporation, Kansai Medical UniversityInventors: Yuji Hirowatari, Katsuko Hara, Hakuo Takahashi
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Patent number: 8070690Abstract: The bone marrow harvesting drill of the invention includes an inner needle having a cutting edge at the tip thereof; a tubular mantle that receives the inner needle thereinto so that the inner needle and the tubular mantle are detachably attached; and a lock mechanism that prevents the axial rotation of the tubular mantle and the inner needle relative to each other; the inner needle having a groove formed at the tip thereof projecting from the tubular mantle for discharging bone scraps produced by the cutting edge at the tip of the inner needle; and the tubular mantle having a cutting edge formed at the tip edge thereof and a helical groove extending from the tip edge to at least part of the peripheral surface of the tubular mantle so as to be flush with the groove of the inner needle.Type: GrantFiled: January 23, 2008Date of Patent: December 6, 2011Assignees: Jimro Co., Ltd., Kansai Medical UniversityInventors: Susumu Ikehara, Hiroshi Shirafuji, Shuji Nakamura, Nobuo Shimoda, Katsuyuki Sado
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Patent number: 7968733Abstract: To provide a pyrrolidine analogue having an inhibitory activity on the induction of allodynia, a method for producing the pyrrolidine analogue, and an agent for preventing a neurogenic pain. A pyrrolidine analogue which is a compound represented by the general formula (I) [wherein HOOC-? represents an aromatic substituent having at least one carboxy group attached to the benzene ring] or a salt or ester of the compound. The compound has a potent inhibitory effect on the induction of allodynia.Type: GrantFiled: May 23, 2007Date of Patent: June 28, 2011Assignees: Gifu University, Kansai Medical University, Osaka Medical CollegeInventors: Masaaki Suzuki, Kyouji Furuta, Toshiaki Minami, Seiji Ito
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Patent number: 7906616Abstract: A method of screening for a medicine capable of regulating generation of elastic fibrous tissue; and various means that are requisite for the method. In particular, the invention includes a polypeptide obtained by cleaving DANCE and a polynucleotide coding for the polypeptide; a method of cleaving DANCE; an antibody against the polypeptide obtained by cleaving DANCE; a method of measuring the amount of DANCE cleavage and a kit therefore; a DANCE variant and its polynucleotide; various DANCE complexes and a method of preparing such; a method of screening for a substance capable of regulating DANCE or a DANCE-specific protease, and a substance obtained by such screening method; an agent for regulating generation of elastic fibrous tissue; and a kit with DANCE and a polynucleotide coding for the same.Type: GrantFiled: March 4, 2005Date of Patent: March 15, 2011Assignee: Kansai Medical UniversityInventors: Tomoyuki Nakamura, Maretoshi Hirai
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Publication number: 20100227318Abstract: The invention relates to a method of intracellularly controlling amounts of gene products, which can increase an amount of gene product intracellularly, comprising a step of introducing into the cell a substance having a sequence complementary to the base sequence of mRNA corresponding to the gene product, its precursor or another substance which can have equivalent action in the cell.Type: ApplicationFiled: June 7, 2007Publication date: September 9, 2010Applicants: AMINO UP CHEMICAL CO., LTD., KANSAI MEDICAL UNIVERSITYInventors: Tadayoshi Okumura, Mikio Nishizawa, Yasuo Kamiyama, Koji Wakame, Takehito Miura
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Publication number: 20090306407Abstract: [Problems] To provide a pyrrolidine analogue having an inhibitory activity on the induction of allodynia, a method for producing the pyrrolidine analogue, and an agent for preventing a neurogenic pain. [Means for Solving the Problems] A pyrrolidine analogue which is a compound represented by the general formula (I) [wherein HOOC-? represents an aromatic substituent having at least one carboxy group attached to the benzene ring] or a salt or ester of the compound. The compound has a potent inhibitory effect on the induction of allodynia.Type: ApplicationFiled: May 23, 2007Publication date: December 10, 2009Applicants: Gifu University, Kansai Medical University, Osaka Medical CollegeInventors: Masaaki Suzuki, Kyouji Furuta, Toshiaki Minami, Seiji Ito
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Patent number: 7417124Abstract: Polyclonal antibody specific for a phosphorylated linker region in Smad2 and/or Smad3.Type: GrantFiled: April 13, 2004Date of Patent: August 26, 2008Assignees: Zeria Pharmaceutical Co., Ltd., Kansai Medical UniversityInventors: Koichi Matsuzaki, Toshihito Seki, Masanori Matsushita, Yoshiya Tahashi, Fukiko Furukawa, Yasushi Sugano, Shigeo Mori, Hideo Yamagata, Katsunori Yoshida, Mikio Nishizawa, Junichi Fujisawa, Keiko Inoue, legal representative, Kyoichi Inoue
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Publication number: 20080177200Abstract: The bone marrow harvesting drill of the invention includes an inner needle having a cutting edge at the tip thereof; a tubular mantle that receives the inner needle thereinto so that the inner needle and the tubular mantle are detachably attached; and a lock mechanism that prevents the axial rotation of the tubular mantle and the inner needle relative to each other; the inner needle having a groove formed at the tip thereof projecting from the tubular mantle for discharging bone scraps produced by the cutting edge at the tip of the inner needle; and the tubular mantle having a cutting edge formed at the tip edge thereof and a helical groove extending from the tip edge to at least part of the peripheral surface of the tubular mantle so as to be flush with the groove of the inner needle.Type: ApplicationFiled: January 23, 2008Publication date: July 24, 2008Applicants: JIMRO CO., LTD., KANSAI MEDICAL UNIVERSITYInventors: Susumu IKEHARA, Hiroshi Shirafuji, Shuji Nakamura, Nobuo Shimoda, Katsuyuki Sado
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Publication number: 20080160562Abstract: A method for assessing arteriosclerosis comprising measuring the serotonin level in whole blood, serum or platelet-rich plasma and rating the serotonin level on such a scale that the lower it is, the more serious the arteriosclerosis is.Type: ApplicationFiled: March 11, 2008Publication date: July 3, 2008Applicants: TOSOH CORPORATION, Kansai Medical UniversityInventors: Yuji Hirowatari, Katsuko Hara, Hakuo Takahashi