Patents Assigned to Kansas State University Research Foundation
  • Patent number: 6654967
    Abstract: Therapy apparel (10) is provided to assist in therapy sessions with children diagnosed with sensory integration dysfunction and impaired motor development. The apparel (10) includes a fabric top (14) to be worn over the shoulders and trunk of a child (12), together with a cape (16) and close-fitting headgear (18). The top (14) has fanciful theme decorations (e.g., a beetle) and is equipped with a series of flexible elastic straps for the feet, knees and hands of the child (12) and which can be used during a therapy session. The cape (18) is likewise theme-decorated and includes handholds (84) allowing the child (12) to spread the cape during imaginative play. The headgear (18) is constructed using padded side and sections (104, 106) with flexible elastic sections (108) between the sections (104, 106), and a chin strap (110) allowing the headgear (18) to be drawn into close conforming relationship with the child's head.
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: December 2, 2003
    Assignee: Kansas State University Research Foundation
    Inventor: Sherry J. Haar
  • Publication number: 20030219893
    Abstract: This invention relates to methods and compositions directed towards the diagnosis and treatment of Hepatitis C virus infection and the screening of potential therapeutic compounds using novel small molecules based on imidazole-4,5-dicarboxylic acids scaffolds.
    Type: Application
    Filed: May 13, 2002
    Publication date: November 27, 2003
    Applicant: Kansas State University Research Foundation
    Inventors: Scott C. Todd, Paul W. Baures
  • Publication number: 20030161818
    Abstract: Stem cells from human sources can have a variety of useful applications in disease treatment and biotechnology. More particularly the umbilical cord matrix stem (UCMS) cell cultures of the invention have a variety of totipotent, pluriotent, or multipotent cells for a variety of end uses from a non-controversial, universally available, species-specific source. The technology can have application to any placental animal, including agricultural and laboratory animals and humans. The invention relates to isolating, culturing the stem cells, maintaining the stem cells, transforming the stem cells into useful cell types using genetic or other transformation technologies, stem cell and tissue banking and using untransformed or transformed cells in disease treatment.
    Type: Application
    Filed: February 25, 2002
    Publication date: August 28, 2003
    Applicant: Kansas State University Research Foundation
    Inventors: Mark L. Weiss, Deryl L. Troyer, Duane Davis, Kathy E. Mitchell
  • Patent number: 6561787
    Abstract: Molding apparatus (10) is provided which allows use of a particulate non-liquid molding material (121) to produce a variety of articles, such as frustoconical barrel segments (122). The apparatus (10) includes a female mold segment (18) including generally annular inner and outer sidewalls (70, 76) and a complemental male mold section (20) having an annular sidewall unit (30). In use, a molding material (121) is placed between the sidewalls (70, 76) and the section (20) is shifted so that it telescopes within the section (18); this compresses the material (121) to a desired final shape, which is then hardened to yield the final product (122). An optional wear insert (26) can be used with female mold section (18), which can be replaced as needed and assists in cleaning of the apparatus (10).
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: May 13, 2003
    Assignees: Kansas State University Research Foundation, Kansas Advanced Technologies, Inc.
    Inventors: Xiuzhi S. Sun, Greggory S. Karr
  • Patent number: 6562403
    Abstract: A method of forming ligated nanoparticles of the formula Y(Z)x where Y is a nanoparticle selected from the group consisting of elemental metals having atomic numbers ranging from 21-34, 39-52, 57-83 and 89-102, all inclusive, the halides, oxides and sulfides of such metals, and the alkali metal and alkaline earth metal halides, and Z represents ligand moieties such as the alkyl thiols. In the method, a first colloidal dispersion is formed made up of nanoparticles solvated in a molar excess of a first solvent (preferably a ketone such as acetone), a second solvent different than the first solvent (preferably an organic aryl solvent such as toluene) and a quantity of ligand moieties; the first solvent is then removed under vacuum and the ligand moieties ligate to the nanoparticles to give a second colloidal dispersion of the ligated nanoparticles solvated in the second solvent. If substantially monodispersed nanoparticles are desired, the second dispersion is subjected to a digestive ripening process.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: May 13, 2003
    Assignee: Kansas State University Research Foundation
    Inventors: Kenneth J. Klabunde, Savka Stoeva, Christopher Sorensen
  • Publication number: 20030072874
    Abstract: A method of forming ligated nanoparticles of the formula Y(Z)x, where Y is a nanoparticle selected from the group consisting of elemental metals having atomic numbers ranging from 21-34, 39-52, 57-83 and 89-102, all inclusive, the halides, oxides and sulfides of such metals, and the alkali metal and alkaline earth metal halides, and Z represents ligand moieties such as the alkyl thiols. In the method, a first colloidal dispersion is formed made up of nanoparticles solvated in a molar excess of a first solvent (preferably a ketone such as acetone), a second solvent different than the first solvent (preferably an organic aryl solvent such as toluene) and a quantity of ligand moieties; the first solvent is then removed under vacuum and the ligand moieties ligate to the nanoparticles to give a second colloidal dispersion of the ligated nanoparticles solvated in the second solvent. If substantially monodispersed nanoparticles are desired, the second dispersion is subjected to a digestive ripening process.
    Type: Application
    Filed: October 15, 2001
    Publication date: April 17, 2003
    Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Kenneth J. Klabunde, Savka Stoeva, Christopher Sorensen
  • Patent number: 6534104
    Abstract: A method for preparing modified ingredients and feed to improve performance and/or feed utilization of animals. An animal feed and method for preparing an animal feed. An enhanced method for preparing an animal feed and an enhanced animal feed. This invention also relates to the use of irradiation technology of a feed component for one animal whereby an enhancement is provided, including but not limited to, feed gain performance and the like.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: March 18, 2003
    Assignee: Kansas State University Research Foundation
    Inventors: Joel M. DeRouchey, Mike D. Tokach, Jim L. Nelssen, Robert D. Goodband, Steve S. Dritz
  • Patent number: 6517277
    Abstract: An expansion or crack joint assembly (32) utilizes a coupler (20) with or without a bottom sheet (34) to join adjacent roadway concrete slabs (86, 90) formed separately initially or continuously cast and later separated by a saw cut, which induces cracking to form a crack joint. The coupler (20) includes a casing (22), an internal component (24,25,62,65), and outer sleeve (26), and end caps (28,30). The casing (22) defines an internal chamber (40) which receives the internal component (24,25,62,65) therein. The sleeve (26) and end caps (28,30) fit over the casing (22). The casing (22) and sleeve (26) transmit loads between the concrete slabs (86,90) while the sleeve (26) and end caps (86,90) operate to reduce stress concentrations. The bottom sheet (34) inhibits water from entering the expansion or crack joint assembly (32) from below, if used, and prevents pumping.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: February 11, 2003
    Assignee: Kansas State University Research Foundation
    Inventors: Kuo-Kuang Hu, Philip G. Kirmser
  • Patent number: 6506423
    Abstract: A feedstuff with reduced ruminal protein degradability is prepared by mixing a carbohydrase enzyme with a material suitable for livestock feed and steeping the mixture under suitable conditions for the carbohydrase enzyme to hydrolyze carbohydrates contained within the material to reducing forms. The mixture is then heated to induce browning so that the protein contained within the material is rendered inert to ruminal degradation. The carbohydrase enzyme may be supplied to the steeping step by the addition of a microorganism capable of secreting the enzyme. A method of feeding a feedstuff with reduced ruminal degradability is also provided.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: January 14, 2003
    Assignee: Kansas State University Research Foundation
    Inventors: James S. Drouillard, Conrad M. Coetzer
  • Patent number: 6497760
    Abstract: Modified soy protein adhesives are provided which have increased bonding abilities. The adhesives are prepared by forming a dispersion of soy protein, water, and a modifier selected from two classes of modifiers. The preferred modifiers are urea, sodium dodecylbenzene sulfonate, sodium dodecyl sulfate, and guanidine hydrochloride. The resulting dispersion is stirred, freeze-dried, and milled into a powder to be stored until use. The adhesives of the invention have superior bonding qualities while being safe for the environment. The urea-modified, GH-modified, SDS-modified, and SDBS-modified soy protein adhesives have higher water resistance than non-modified soy protein adhesives.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: December 24, 2002
    Assignee: Kansas State University Research Foundation
    Inventors: Xiuzhi Sun, Ke Bian
  • Patent number: 6496262
    Abstract: The proposed holographic particle image velocimetry (HPIV) system employs holograms of two time-separated particle fields, illuminated by separate reference beams on a single recording medium. 90-degree scattering is utilized for the object wave, in order to improve Numerical Aperture and resolve the third dimension of the hologram. The proposed HPIV system then uses substantially the same optical geometry for the reconstruction process. A CCD camera is utilized to extract particle subimages, thin slice by thin slice, and a centroid-finding algorithm is applied to extract centroid locations for each volume. The concise cross correlation (CCC) algorithm for extracting velocity vector fields from the centroid data is an important enabling feature of the proposed system. Correlations are calculated between subsets of centroids representing the images or cubes, and velocity vectors are computed from the individual correlations.
    Type: Grant
    Filed: July 9, 1999
    Date of Patent: December 17, 2002
    Assignee: Kansas State University Research Foundation
    Inventors: Hui Meng, Ye Pu
  • Patent number: 6451856
    Abstract: The present invention relates to a method of feeding carnitine supplemented diets to sows during the period of gestation or during both gestation and lactation periods. The method enhances pork productivity by increasing litter and pig birth and weaning weights, reducing the number of stillborn pigs and increasing the number of pigs born alive in the subsequent reproductive cycle. Sow diets of this invention include carnitine, such as L-carnitine or L-carnitine salts. Carnitine is generally added to the swine feed formulation in the amount of from about 5 to about 5,000 ppm.
    Type: Grant
    Filed: July 18, 2000
    Date of Patent: September 17, 2002
    Assignees: Lonza Inc., Kansas State University Research Foundation
    Inventors: Stephen A. Blum, Kevin Q. Owen, Jim L. Nelssen, Robert D. Goodband, Michael D. Tokach, Rene A. Blum, Robert E. Musser
  • Patent number: 6410940
    Abstract: A micro-size LED-like optical element has an n-contact, a p-contact, and an optical active structure connected between the n-contact and the p-contact for generating light when forward biased and for detecting light when reverse biased. The optical active structure has a diameter of about 20 &mgr;m or smaller. When the the optical active structure is forward biased, it forms a micro-size LED (&mgr;LED). When the optical active structure is reverse biased, it forms a micro-size detector (&mgr;detector). An array of the micro-size optical active structures may be used as a minidisplay, a detector, or a sensor (when each structure is separately wired), or as a hyperbright LED (when the structures are wired to turn on and off simultaneously). Alternatively, a hyperbright LED may be obtained by forming a plurality of micro-size holes extending into an LED wafer.
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: June 25, 2002
    Assignee: Kansas State University Research Foundation
    Inventors: Hongxing Jiang, Jingyu Lin, Sixuan Jin, Jing Li
  • Patent number: 6401249
    Abstract: Therapy apparel (10) is provided to assist in therapy sessions with children diagnosed with sensory integration dysfunction and impaired motor development. The apparel (10) includes a fabric top (14) to be worn over the shoulders and trunk of a child (12), together with a cape (16) and close-fitting headgear (18). The top (14) has fanciful theme decorations (e.g., a beetle) and is equipped with a series of flexible elastic straps for the feet, knees and hands of the child (12) and which can be used during a therapy session. The cape (18) is likewise theme-decorated and includes handholds (84) allowing the child (12) to spread the cape during imaginative play. The headgear (18) is constructed using padded side and sections (104, 106) with flexible elastic sections (108) between the sections (104, 106), and a chin strap (110) allowing the headgear (18) to be drawn into close conforming relationship with the child's head.
    Type: Grant
    Filed: April 25, 2001
    Date of Patent: June 11, 2002
    Assignees: Kansas State University Research Foundation, Virginia Tech Intellectual Properties, Inc.
    Inventors: Sherry J. Haar, Joann F. Boles
  • Patent number: 6383128
    Abstract: Improved methods and compositions for decreasing the bioavailability of metals in soil are provided. Broadly, the methods comprise mixing a source of phosphorus and an oxide of manganese with the contaminated soil so as to reduce the metal bioavailability in the soil. The phosphorus source and oxide of manganese can be individually mixed with the soil, or can be provided as a premix powder or granule to be mixed with the contaminated soil. Preferably, the pH of the soil is then adjusted to, and maintained at, a level of at least about 7.0. Preferred phosphorus sources include phosphate rock, alkali and alkaline earth metal phosphates, ammonium phosphates, ammonium orthophosphates, orthophosphoric acid, and superphosphates. Preferred oxides of manganese include MnO2, Mn3O4, birnessite, cryptomelane, and psilomelanes.
    Type: Grant
    Filed: March 16, 2000
    Date of Patent: May 7, 2002
    Assignee: Kansas State University Research Foundation
    Inventors: Gary M. Pierzynski, Ganga M. Hettiarachchi
  • Patent number: 6384045
    Abstract: This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxypyrone synthetic method is a simple condensation reaction of pyrones with cyclohexenecarboxaldehydes, providing high yields and using few steps. The tetracyclic oxypyrone synthetic method is a simple condensation reaction of carvones with pyrones.
    Type: Grant
    Filed: June 24, 1999
    Date of Patent: May 7, 2002
    Assignee: Kansas State University Research Foundation
    Inventors: Duy H. Hua, Jean-Pierre Perchellet
  • Patent number: 6349485
    Abstract: A high capacity grain aeration apparatus (10) is provided which includes opposed, upright, tubular, ported inlet and outlet ducts (24,26) positioned within a grain bin (12) and having inlet and outlet fans (28, 30) adjacent the upper ends of the ducts (24, 26). The ducts (24, 26) preferably present smooth, uncorrugated walls (40, 44). In use, aeration air is directed through the inlet duct (24) and then transversely through the ports (42) to the interior (20) of grain bin (12). Such air flows transversely through the grain within bin (12) and is pulled upwardly through outlet duct (26) by means of outlet fan (30). Additional aeration air enters through vents (50) or the grain inlet port (47) and enters the outlet duct ports (46) by passing through the grain.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: February 26, 2002
    Assignee: Kansas State University Research Foundation
    Inventor: Carl Reed
  • Patent number: 6337097
    Abstract: Biodegradable and edible composites for use as feed packaging containers are provided. Broadly, the composites are formed from a mixture comprising fiber mixed with a non-petroleum based, biodegradable adhesive formed by modifying a starch, protein, or protein-rich flour. The mixture has a moisture content of less than about 20% by weight, based upon the total weight of the mixture taken as 100% by weight. The mixture is then molded at pressures of from about 150-600 psi and temperatures of from about 150-500° F. to yield a final composite having a compressive strength of at least about 5 MPa. Preferred fibers include those derived from straw, corn stalks, sorghum stalks, soybean hulls, and peanut hulls. Preferred modifiers include NaOH, urea sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, and guanidine hydrochloride.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: January 8, 2002
    Assignee: Kansas State University Research Foundation
    Inventors: Xiuzhi S. Sun, Paul Seib, Greggory S. Karr
  • Publication number: 20010054192
    Abstract: Therapy apparel (10) is provided to assist in therapy sessions with children diagnosed with sensory integration dysfunction and impaired motor development. The apparel (10) includes a fabric top (14) to be worn over the shoulders and trunk of a child (12), together with a cape (16) and close-fitting headgear (18). The top (14) has fanciful theme decorations (e.g., a beetle) and is equipped with a series of flexible elastic straps for the feet, knees and hands of the child (12) and which can be used during a therapy session. The cape (18) is likewise theme-decorated and includes handholds (84) allowing the child (12) to spread the cape during imaginative play. The headgear (18) is constructed using padded side and sections (104, 106) with flexible elastic sections (108) between the sections (104, 106), and a chin strap (110) allowing the headgear (18) to be drawn into close conforming relationship with the child's head.
    Type: Application
    Filed: April 25, 2001
    Publication date: December 27, 2001
    Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Sherry J. Haar, Joann F. Boles
  • Patent number: 6299907
    Abstract: Reversible swellable modified starch products are provided in the form of individual, chemically cross-linked starch granules capable of undergoing multiple hot or cold water swelling/drying cycles without losing the individuality of the starch granules, and with essentially no loss of starch solubles. The starches are prepared by forming a dispersion of starch granules in water, with the granules undergoing swelling and having a crystalline phase; a cross-linker (preferably a phosphorylating agent) is added to the dispersion in order to cross-link the starch under conditions to avoid complete gelatinization thereof. The swollen/cross-linked starch granules are then heated in excess water in order to melt the crystalline phase of the granules. The granules exhibit a network-like structure with internal voids.
    Type: Grant
    Filed: June 12, 1998
    Date of Patent: October 9, 2001
    Assignee: Kansas State University Research Foundation
    Inventors: Paul A. Seib, Kyungsoo Woo