Patents Assigned to Kanto Ishi Pharmaceutical Co., Ltd.
  • Patent number: 4990604
    Abstract: Method for the production of asialoganglioside related compounds of the formula (I). ##STR1## wherein R.sup.1 is hydrogen or benzoyl, R.sup.2 is hydrogen or acetyl, R.sup.3 is hydrogen, acetyl, .beta.-D-galactopyranosyl or 2,3,4,6-tetra-O-acetyl-.beta.-D-galactopyranosyl, R.sup.7 and R.sup.8 are individually alkyl having 1 to 30 carbon atoms and Ac is acetyl.
    Type: Grant
    Filed: February 24, 1986
    Date of Patent: February 5, 1991
    Assignees: Rikagaku Kenkyusho, Kanto Ishi Pharmaceutical Co., Ltd., Teikoku Chemical Industry Co., Ltd.
    Inventors: Tomoya Ogawa, Mamoru Sugimoto, Yoshiyasu Shitori, Toshio Horisaki, Tadami Shinuchi
  • Patent number: 4694076
    Abstract: Sialic acid derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, trityl, or acyl, R.sup.2 is hydrogen or acyl, R.sup.3 and R.sup.4 are individually glycerolglycoside, dialkylglycerol, alkoxycarbonyl or carboxyl.These compounds may be employed as a useful intermediate for the synthesis of biologically active substances and may be employed as an inhibitor of hydrolytic enzyme, a reagent for affinity chromatography for purifying enzyme, or a synthetic antigen.
    Type: Grant
    Filed: December 11, 1984
    Date of Patent: September 15, 1987
    Assignees: Kanto Ishi Pharmaceutical Co., Ltd., Rikagaku Kenkyusho
    Inventors: Tomoya Ogawa, Mamoru Sugimoto, Yoshiyasu Shitori, Masayoshi Ito
  • Patent number: 4675391
    Abstract: This invention provides a novel compound having a formula such as ##STR1## This invention also provides a process for preparing such a compound. The novel compound has excellent immunological activity.
    Type: Grant
    Filed: February 24, 1986
    Date of Patent: June 23, 1987
    Assignee: Kanto Ishi Pharmaceutical Co., Ltd.
    Inventors: Shohei Shibayama, Yuzi Matsuzaki, Shoji Yoshimura, Masayoshi Ito, Yoshiyasu Shitori, Tomoya Ogawa
  • Patent number: 4663443
    Abstract: This invention provides a novel compound having a formula such as ##STR1## This invention also provides a process for preparing such a compound. The novel compound has an excellent immunological activity.
    Type: Grant
    Filed: May 1, 1985
    Date of Patent: May 5, 1987
    Assignee: Kanto Ishi Pharmaceutical Co., Ltd.
    Inventors: Shohei Shibayama, Shoji Yoshimura, Masayoshi Ito, Yoshiyasu Shitori, Tomoya Ogawa
  • Patent number: 4656260
    Abstract: A novel compound, 3-(.beta.-D-ribofranosyl)pyrazolo-[3,4-e] [1,3]oxazine-5,7-dione, exhibiting a function of inhibiting propagation or growth of various virus, and a process for preparing the same.
    Type: Grant
    Filed: December 27, 1984
    Date of Patent: April 7, 1987
    Assignee: Kanto Ishi Pharmaceutical Co., Ltd.
    Inventors: Tetsuzo Kato, Nobuya Katagiri
  • Patent number: 4447600
    Abstract: Nucleoside or glucose derivatives of N-acetylneuraminic acids are provided, which have immunological activity, are clinically useful, as an immuno suppressive, in particular to treat autoimmune disease such as collagenosis disease without causing any serious side-effects and may be prepared by subjecting a halide of N-acetylneuraminate derivative together with a nucleoside or a glucose to Koenigs-Knorr reaction.
    Type: Grant
    Filed: May 20, 1982
    Date of Patent: May 8, 1984
    Assignee: Kanto Ishi Pharmaceutical Co., Ltd.
    Inventors: Haruo Ogura, Kimio Furuhata, Toshiaki Osawa, Satoshi Toyoshima, Yoshiyasu Shitori, Masayoshi Ito
  • Patent number: 4436904
    Abstract: Novel cephalosporin derivatives are described which have excellent antibiotic activity against pathogenic bacteria belonging to the Pseudomonas, Serratia and Enterobacter. The compounds have general formula ##STR1## in which R is hydrogen, acyloxy, carbamoyloxy, a substituted or unsubstituted pyridinium group or a group -S-Het in which Het represents a substituted or unsubstituted, hetero atom-containing, 5- or 6-membered heterocyclic ring, R' is hydrogen, alkali metal, an organic amine or an ester moiety, R.sub.1 and R.sub.2 are the same or different and are hydrogen or a lower alkyl and B stands for a 1,4-cyclohexadienyl group, a group ##STR2## in which Y is hydrogen, --OH or ##STR3## in which R.sub.5 is an alkyl of 1 to 5 carbon atoms, aryl or alkoxy having 1 to 4 carbon atoms, Z stands for hydrogen or halogen and p is an integer of 1 or 2, a furan group or a thiophene group. Methods of preparation are described.
    Type: Grant
    Filed: January 6, 1982
    Date of Patent: March 13, 1984
    Assignee: Kanto Ishi Pharmaceutical Co., Ltd.
    Inventors: Shigeo Shimizu, Hiroyuki Takano, Shoji Yoshimura, Kinji Takada