Patents Assigned to Kaohsiung Chang Gung Memorial Hospital
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Patent number: 11851708Abstract: Methods and kits for diagnosing or predicting the risk of developing psoriatic arthritis in a subject in need of such diagnosis or risk prediction are provided, comprising measuring the expression level of one or more miRNAs disclosed herein in the sample of the subject, and compared the expression level of at least one of the miRNAs in the test sample with that of the psoriatic arthritis-free sample. Also provided are methods of treating psoriatic arthritis by reducing the expression level of at least one of the miRNAs disclosed herein.Type: GrantFiled: November 26, 2021Date of Patent: December 26, 2023Assignee: KAOHSIUNG CHANG GUNG MEMORIAL HOSPITALInventors: Shang-Hung Lin, Chih-Hung Lee, Chang-Chun Hsiao
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Publication number: 20230281944Abstract: A method for categorizing and adjusting an orientation of a clinical image is implemented using a system that includes a categorization module and a plurality of orientation modules. The method includes: in response to receipt of the clinical image, performing, by the categorization module, a categorization operation so as to categorize the clinical image into one of a plurality of predetermined categories; transmitting the clinical image to a corresponding one of the plurality of orientation modules based on a result of the categorization operation; and performing, by the corresponding one of the plurality of orientation modules, an orientation adjusting operation for adjusting the orientation of the clinical image. For a clinical image that is a facial image and for a clinical image that is an intra-oral image, different orientation adjusting operations may be performed, so as to generate an adjusted image that is properly oriented.Type: ApplicationFiled: January 24, 2023Publication date: September 7, 2023Applicant: KAOHSIUNG CHANG GUNG MEMORIAL HOSPITALInventors: Te-Ju Wu, Tzuo-Yau Fan, Yueh-peng Chen, Chin-Yi Ji, Chang-Fu Kuo
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Publication number: 20230134678Abstract: An operating method of a ketogenic dietary evaluation system includes steps as follows. The electroencephalogram data of a responder group and the electroencephalogram data of a non-responder group are preloaded, in which each electroencephalogram datum includes electroencephalograms of channels. The electroencephalograms of the channels are preprocessed to obtain the preprocessed electroencephalograms of the channels. A connectivity matrix is obtained on a basis of the phase synchronization between each two of the preprocessed electroencephalograms of the channels. The connectivity matrix is sampled and analyzed through different frequency bands and different proportion threshold values to obtain graphical parameters. A predictive model is established on a basis of a reduction rate of a predetermined event of the responder group, a reduction rate of the predetermined event of the non-responder group and the parameters.Type: ApplicationFiled: November 2, 2022Publication date: May 4, 2023Applicants: Kaohsiung Chang Gung Memorial Hospital, Taipei Medical University (TMU)Inventors: Pi-Lien Hung, Syu-Jyun Peng
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Patent number: 11238591Abstract: A medical image processing system includes a memory and a processor coupled to each other. The processor accesses and executes instructions which memory stores to perform the following: obtaining a plurality of brain MR images corresponding to a subject, wherein the brain MR images corresponds to a subject brain space; accessing a DBS targets atlas corresponding to a specific stimulation area; transforming the DBS targets atlas from a MNI brain space to the subject brain space based on a DARTEL algorithm; marking at least one coordinate having a largest Voxel value in the brain MR images based on the transformed DBS targets atlas; and storing the brain MR images being targeted with the at least one coordinate into a predetermined format corresponding to a guiding device so that the guiding device displays the brain MR images being targeted with the at least one coordinate for guidance in DBS procedure.Type: GrantFiled: July 15, 2020Date of Patent: February 1, 2022Assignees: Taipei Medical University (TMU), Kaohsiung Chang Gung Memorial HospitalInventors: Syu-Jyun Peng, Fu-Yuan Shih
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Patent number: 11197645Abstract: A system and method of throat abnormal object recognition is disclosed. The system includes a throat abnormal object recognition device, a data source device, a display device, and an operation device connected to the throat abnormal object recognition device, the data source device, and the display device. The method includes the throat abnormal object recognition device generating operation parameters, the data source device generating an original X-ray image data, the throat abnormal object recognition device reading the original X-ray image data, performing a pre-stage process on the original X-ray image data to generate a pre-stage processed image data, performing a comparison process on the pre-stage processed image data to generate a comparison processed image data with an abnormal object image, employing a frame mark to mark the abnormal object image as a mark X-ray image, and employing the display device to display the mark X-ray image.Type: GrantFiled: October 23, 2020Date of Patent: December 14, 2021Assignees: Kaohsiung Chang Gung Memorial HospitalInventors: Wei-Che Lin, Yueh-Sheng Chen, Sheng-Dean Luo, Jian-Feng Lin, You-Nan Chen
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Patent number: 11045347Abstract: An artificial stoma device includes a solid unit and a hollow unit. The solid unit includes a blocking member that is adapted to block off a downstream section of an intestine and that has a contacting face adapted for facing an upstream section of the intestine, and a first connecting member that is connected fixedly to the contacting face of the blocking member. The hollow unit includes a conduit that has an outer surrounding surface and two opposite conduit openings being adapted to be disposed respectively at the upstream section of the intestine and an opening of a skin tissue, and a second connecting member that is connected fixedly to the outer surrounding surface and that is detachably connected to the first connecting member of the solid unit.Type: GrantFiled: March 4, 2019Date of Patent: June 29, 2021Assignee: Kaohsiung Chang Gung Memorial HospitalInventor: Chi-Tung Lu
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Patent number: 10888556Abstract: Pharmaceutical compositions containing a combination of anti-chondrogenesis agents are disclosed. Methods of reducing scleral chondrogensis, reducing one or more ocular chondrogenic proteins, reducing inflammation induced chondrogensis and treating myopia by administering an effective amount of one or more anti-chondrogensis agents are also provided. The pharmaceutical compositions are useful for treating myopia.Type: GrantFiled: December 3, 2019Date of Patent: January 12, 2021Assignees: Kaohsiung Chang Gung Memorial HospitalInventors: Pei-Chang Wu, Chia-Ling Tsai, Chueh-Tan Chen
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Patent number: 10610863Abstract: An automatic microfluidic system for antibiotic susceptibility testing of the present disclosure at least includes a microfluidic chip. The microfluidic chip includes a fluid storage unit, a reaction unit, a pneumatic micro-pumping unit and a plurality of valve units. The fluid storage unit is provided for storing a bacterial suspension, a broth and an antibiotic solution. The reaction unit includes a first reaction chamber and at least two second reaction chambers. The pneumatic micro-pumping unit is adjacently disposed to the fluid storage unit and the reaction unit for selectively, repeatedly and quantitatively transporting the broth, the bacterial suspension and the antibiotic solution to the reaction unit to form a first mixing solution and at least two second mixing solutions. The valve units include a plurality of pneumatic micro-valves and a plurality of valve control air holes for controlling the opening and closing of the pneumatic micro-valves.Type: GrantFiled: May 1, 2017Date of Patent: April 7, 2020Assignees: NATIONAL TSING HUA UNIVERSITY, Kaohsiung Chang Gung Memorial HospitalInventors: Gwo-Bin Lee, Shiuann-Sheng Lee, Wen-Bin Lee, Wen-Hsin Chang
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Patent number: 10548887Abstract: Pharmaceutical compositions containing a combination of anti-chondrogenesis agents are disclosed. Methods of reducing scleral chondrogenesis, reducing one or more ocular chondrogenic proteins, reducing inflammation induced chondrogenesis and treating myopia by administering an effective amount of one or more anti-chondrogenesis agents are also provided. The pharmaceutical compositions are useful for treating myopia.Type: GrantFiled: April 20, 2018Date of Patent: February 4, 2020Assignees: Kaohsiung Chang Gung Memorial Hospital, Philip WUInventors: Pei-Chang Wu, Chia-Ling Tsai, Chueh-Tan Chen
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Patent number: 10473672Abstract: A method for diagnosing Alzheimer's disease (AD) includes: obtaining a blood sample from a human subject suspected of having AD; determining a G72 protein level in the blood sample; determining an SLC7A11 mRNA expression level in the blood sample; comparing the G72 protein level with a first predetermined standard; comparing the SLC7A11 mRNA expression level with a second predetermined standard; and diagnosing the human subject with AD when the G72 protein level is higher than the first predetermined standard and the SLC7A11 mRNA expression level is higher than the second predetermined standard. An effective amount of a pharmaceutical composition may be administered to the diagnosed human subject for treating AD.Type: GrantFiled: February 9, 2017Date of Patent: November 12, 2019Assignees: KAOHSIUNG CHANG GUNG MEMORIAL HOSPITAL, CHINA MEDICAL UNIVERSITYInventors: Chieh-Hsin Lin, Hsien-Yuan Lane
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Patent number: 10358676Abstract: Kits for detecting Kawasaki disease, containing an agent for sequencing or measuring the expression level of one or more of the following: miR-941, miR-182-5p and miR-183-5p are provided. Methods for detecting Kawasaki disease in a subject, comprising the identifying of one or more of the following in the subject: miR-941, miR-182-5p and miR-183-5p, are also provided.Type: GrantFiled: February 25, 2016Date of Patent: July 23, 2019Assignee: Kaohsiung Chang Gung Memorial HospitalInventors: Ho-Chang Kuo, Sung-Chou Li, Wen-Ching Chan