Patents Assigned to Kara Bio AB
  • Estrogen receptor ligands
    Patent number: 6476196
    Abstract: The present invention is directed to crystals of ER&bgr; ligand binding domain complexed with (1) N-(n-butyl)-11-[3,17&bgr;-dihydroxyestra-1,3,5(10)-trien-7&agr;-yl]N-methylundecanamide; estradiol and a peptide comprising the amino acid sequence LXXLL; or 17-epiestriol and a peptide comprising the amino acid sequence LXXLL.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: November 5, 2002
    Assignee: Kara Bio AB
    Inventors: Jan Ljunggren, Ann-Gerd Thorsell, Owe Engstrom, Tomas Bonn, Mats Carlquist, Andrzeji Brzozowski, Ashley Pike, Roderick Hubbard
  • Estrogen receptor ligands
    Patent number: 6228990
    Abstract: The application relates to a crystal comprising at least 150 amino acid residues of the estrogen receptor-&bgr; (ER&bgr;) ligand binding domain complexed with a ligand which is an antagonist or a partial agonist.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: May 8, 2001
    Assignee: Kara Bio AB
    Inventors: Jan Ljunggren, Ann-Gerd Thorsell, Owe Engstrom, Tomas Bonn, Mats Carlquist, Andrzej M. Brzozowski, Ashley C. W. Pike, Roderick E. Hubbard