Patents Assigned to KARIUS, INC.
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Patent number: 11834711Abstract: The disclosure provides methods, compositions, systems, and kits for the concurrent detection and analysis of different structural and chemical forms of nucleic acids in a sample.Type: GrantFiled: September 24, 2021Date of Patent: December 5, 2023Assignee: Karius, Inc.Inventors: Timothy A Blauwkamp, Rene Sit, Igor D. Vilfan
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Patent number: 11692224Abstract: This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.Type: GrantFiled: June 23, 2021Date of Patent: July 4, 2023Assignee: Karius, Inc.Inventors: Fred C. Christians, Igor D. Vilfan, Michael Kertesz, Timothy A. Blauwkamp, Shivkumar Venkatasubrahmanyam, Michael Rosen, Rene Sit
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Patent number: 11674167Abstract: This disclosure provides methods, compositions and kits for determining if nucleic acids detected in a sample such as a clinical sample are derived from contaminant pathogens or clinically-relevant pathogens.Type: GrantFiled: May 27, 2020Date of Patent: June 13, 2023Assignee: Karius, Inc.Inventors: Timothy A. Blauwkamp, Liza Huijse, Michael Rosen, Igor D. Vilfan
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Publication number: 20220010303Abstract: Provided herein are direct-to-library methods, systems, and compositions.Type: ApplicationFiled: May 18, 2021Publication date: January 13, 2022Applicant: KARIUS, INC.Inventors: Sivan BERCOVICI, Lily BLAIR, Timothy A. BLAUWKAMP, Peter J. EUGSTER, David K. HONG, Trupti KAWLI, Michael J. ROSEN, Damek SPACEK, Igor D. VILFAN
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Publication number: 20210403986Abstract: Provided herein are fragment length profiles of nucleic acid libraries, methods of generating fragment length profiles of nucleic acid libraries and methods of using fragment length profiles for diagnostics and/or prognostics. The application further provides methods, compositions and kits for determining the infection stage or the site of localization in a subject.Type: ApplicationFiled: May 18, 2021Publication date: December 30, 2021Applicant: KARIUS, INC.Inventors: Sivan BERCOVICI, Lily BLAIR, Timothy A. BLAUWKAMP, Peter J. EUGSTER, Desiree HOLLEMON, David K. HONG, Trupti KAWLI, Mark Alec KOWARSKY, Martin M.S. LINDNER, Michael J. ROSEN, Damek SPACEK, Igor D. VILFAN
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Patent number: 11180800Abstract: The disclosure provides methods, compositions, systems, and kits for the concurrent detection and analysis of different structural and chemical forms of nucleic acids in a sample.Type: GrantFiled: May 13, 2020Date of Patent: November 23, 2021Assignee: Karius, Inc.Inventors: Timothy A. Blauwkamp, Rene Sit, Igor D. Vilfan
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Patent number: 11111520Abstract: This disclosure provides methods and compositions that are useful for enriching a particular population of nucleic acids (a “population of interest”) within a complex mixture of nucleic acids. The population of interest may make up a minor portion of a complex mixture of nucleic acids. The methods and compositions provided herein are useful for detecting, predicting, diagnosing, or monitoring a disease or disorder, particularly a disease or disorder caused by a foreign microbe or pathogen.Type: GrantFiled: May 17, 2016Date of Patent: September 7, 2021Assignee: Karius, Inc.Inventors: Timothy A. Blauwkamp, Fred Christians, Igor D. Vilfan, Scott Smith, Michael Kertesz
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Patent number: 11078532Abstract: This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.Type: GrantFiled: April 16, 2018Date of Patent: August 3, 2021Assignee: Karius, Inc.Inventors: Fred C. Christians, Igor D. Vilfan, Michael Kertesz, Timothy A. Blauwkamp, Shivkumar Venkatasubrahmanyam, Michael Rosen, Rene Sit
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Publication number: 20200291457Abstract: This disclosure provides methods, compositions and kits for determining if nucleic acids detected in a sample such as a clinical sample are derived from contaminant pathogens or clinically-relevant pathogens.Type: ApplicationFiled: May 27, 2020Publication date: September 17, 2020Applicant: KARIUS, INC.Inventors: Timothy A. BLAUWKAMP, Liza HUIJSE, Michael ROSEN, Igor D. VILFAN
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Patent number: 10697008Abstract: The disclosure provides methods, compositions, systems, and kits for the concurrent detection and analysis of different structural and chemical forms of nucleic acids in a sample.Type: GrantFiled: April 12, 2018Date of Patent: June 30, 2020Assignee: KARIUS, INC.Inventors: Timothy A. Blauwkamp, Rene Sit, Igor D. Vilfan
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Patent number: 9976181Abstract: This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.Type: GrantFiled: March 24, 2017Date of Patent: May 22, 2018Assignee: KARIUS, INC.Inventors: Fred C. Christians, Igor D. Vilfan, Michael Kertesz, Timothy A. Blauwkamp, Shivkumar Venkatasubrahmanyam, Michael Rosen, Rene Sit
