Abstract: The present invention relates to carboxylic acid derivatives of the general formula ##STR1## in which R.sub.a to R.sub.c, A, B, D, E and X.sub.1 to X.sub.3 are as defined in claim 1, their tautomers, their stereoisomers including their mixtures, and their salts, in particular their physiologically tolerated salts with inorganic or organic acids or bases, which have useful pharmacological properties, preferably aggregation-inhibiting inhibiting actions, medicaments containing these compounds, their use and processes for their preparation.
Type:
Grant
Filed:
April 3, 1997
Date of Patent:
November 30, 1999
Assignee:
Karl Thomae
Inventors:
Helmut Pieper, Gunter Linz, Volkhard Austel, Frank Himmelsbach, Brian Guth, Johannes Weisenberger
Abstract: The invention relates to cyclic imino derivatives of general formulaB--X.sub.5 --X.sub.4 --X.sub.3 --X.sub.2 --X.sub.1 --A--Y--E(I)whereinA, B, E, X.sub.2 to X.sub.5 and Y are defined as in claim 1, the stereoisomers, tautomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, preferably aggregation-inhibiting effects, pharmaceutical compositions which contain these compounds and processes for preparing them.
Type:
Grant
Filed:
December 23, 1993
Date of Patent:
October 3, 1995
Assignee:
Karl Thomae
Inventors:
Volkhard Austel, Wolfgang Eisert, Frank Himmelsbach, Guenter Linz, Thomas Mueller, Helmut Pieper, Johannes Weisenberger
Abstract: Stable, dosage forms of .alpha.-interferons, particularly alpha-2-interferon, are described, which comprise a non-lyophilized dry film of acid-stabilized .alpha.-interferons, e.g. alpha-2-interferon, on inert carriers.
Type:
Grant
Filed:
August 21, 1987
Date of Patent:
April 25, 1989
Assignee:
Karl Thomae
Inventors:
Robert Becker, Bernd Kruss, Leonhard Schilk
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