Abstract: This invention relates to vehicles for the administration of dipyridamole. More specifically, this invention relates to a method of treating cardiovascular disorders in a host in need of such treatment which comprises administering to said host a cardiovascularly effective amount of a composition comprised of (i) dipyridamole or an acid addition salt thereof and (ii) at least one pharmacologically acceptable acid or acid substance, the total amount of acid from acid addition salt present and acid or acid substance being in a ratio of at least about 5 acid equivalents to 1 mol of dipyridamole, preferably in the form of particles having particle sizes of from about 0.1 to 2.0 mm.
Type:
Grant
Filed:
June 17, 1982
Date of Patent:
January 24, 1984
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Rolf Brickl, Peter Gruber, Gottfried Schepky, Gerhard Bozler
Abstract: This invention relates to compounds of the formula ##STR1## wherein R is (1-methyl-4-piperidinyl)methyl, (1-methyl-1,2,5,6-tetrahydro-4-pyridinyl)methyl, 1-methyl-1,2,5,6-tetrahydro-4-pyridinyl, (1-methyl-4-piperidinylidene)methyl, 2,3-dehydro-8-methyl-8-azabicyclo?3.2.1!oct-3-yl methyl, endo-8-methyl-8-azabicyclo?3.2.1!oct-3-yl-methyl, or exo-8-methyl-8-azabicyclo?3.2.1!oct-3-yl-methyl, each of which may optionally have one or two methyl substituents on the six-membered heterocyclic ring, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as anti-ulcerogenics.
Type:
Grant
Filed:
January 31, 1983
Date of Patent:
January 3, 1984
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Wolfgang Eberlein, Gu/ nter Trummlitz, Gu/ nther Schmidt, Wolfhard Engel, Rudolf Hammer, Piero Del Soldato
Abstract: New pyridobenzodiazepinones of the formula ##STR1## are described wherein X represents oxygen, --NH-- or --NCH.sub.3 -- and R represents 1-methyl-4-piperidinyl or 4-methyl-1-piperazinyl group optionally substituted by a methyl group, or a 3.alpha.- or 3.beta.-tropanyl group, and the nontoxic pharmaceutically acceptable acid addition salts thereof. The specification also describes processes for preparing these compounds, pharmaceutical compositions containing these compounds and new intermediate products used in preparing them.The compounds of formula I have antiulcerative effects and an inhibitory effect on gastric acid secretion, without the side effects such as dryness of the mouth and mydriasis which occur with other substances having an anticholinergic activity.
Type:
Grant
Filed:
January 31, 1983
Date of Patent:
January 3, 1984
Assignee:
Karl Thomae GmbH
Inventors:
Wolfhard Engel, Gu/ nther Schmidt, Gu/ nther Trummlitz, Wolfgang Eberlein, Rudolf Hammer, Piero D. Soldato
Abstract: This invention relates to novel compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl having from 1 to 4 carbon atoms;R.sub.2 is halogen, hydrogen, or alkyl having from 1 to 4 carbon atoms; andR is (1-methyl-4-piperidinyl)methyl, (1-methyl-1,2,5,6-tetrahydro-4-pyridinyl)methyl, 1-methyl-1,2,5,6-tetrahydro-4-pyridinyl, (1-methyl-4-piperidinylidene)-methyl, or (8-methyl-8-azabicyclo?3.2.1!oct-3-yl)-methyl, each of which can optionally have an additional methyl substituent on the heterocyclic ring,and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as anti-ulcerogenics.
Type:
Grant
Filed:
January 31, 1983
Date of Patent:
January 3, 1984
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Gu/ nther Schmidt, Wolfgang Eberlein, Wolfhard Engel, Gu/ nter Trummlitz, Rudolf Hammer, Piero Del Soldato
Abstract: This invention relates to an apparatus for dispensing small quantities of fluid which comprises a hinged clamping member with a bellows attachment for receiving an elongated cylindrical tube containing fluid and having sealed ends, wherein the hinged clamping member consists of two half-shells which enclose an inner space; the two half-shells are enclosed by a retaining and supporting member; the retaining and supporting member consists of symmetrical halves which are connected to each other by a hinge; the inner diameter of the inner space corresponds to the outer diameter of the tube; the two halves of the retaining and supporting member have, adjacent to the hinge, recesses with stops and, on the side opposite the hinge, a locking or snap-fit member; the hinged half-shells comprise, at one end, a shaft whose outer diameter corresponds to the inner diameter of the cylindrical shaft of a bellows attachment; the bellows attachment is provided with an opening which permits the bellows attachment to be pushed u
Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or hydroxyl, and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases. The compounds as well as their salts are useful as sweetening agents.
Type:
Grant
Filed:
April 15, 1981
Date of Patent:
September 13, 1983
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Gunter Trummlitz, Wolfgang Eberlein, Wolfhard Engel, Gunther Schmidt
Abstract: This invention is directed to the compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or an alkyl of from 1 to 6 carbon atoms;R.sub.2 is an alkyl of from 1 to 3 carbon atoms;R.sub.3 is hydrogen or an alkyl of from 1 to 3 carbon atoms; andR.sub.4 is hydrogen or an alkyl of from 1 to 4 carbon atoms.These compounds are useful in pharmaceutical compositions which serve as analgesics, antiphlogistics and antipyretics.
Abstract: Compounds of the formula ##STR1## wherein each X, which may be identical or different from the other X, is oxygen or imino;R.sub.1 is hydrogen, fluorine, chlorine or bromine;R.sub.2 and R.sub.3, which may be identical or different from each other, are each hydrogen; unsubstituted or mono-substituted alkyl of 1 to 6 carbon atoms, where the substituent is phenyl or dialkylamino with 1 to 3 carbon atoms in each alkyl moiety; pyridyl; or cycloalkyl of 5 to 7 carbon atoms;R.sub.2 and R.sub.
Type:
Grant
Filed:
June 11, 1980
Date of Patent:
December 7, 1982
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Johannes Keck, Gerd Kruger, Helmut Pieper, Klaus Noll, Gunther Engelhardt, Norbert Promberger, Rainer Zimmermann
Abstract: Compounds of the formula ##STR1## wherein A is phenyl, p-hydroxy-phenyl, 2-thienyl, 3-thienyl or 3,4-disubstituted phenyl, where the substituents, which may be identical to or different from each other, are each chlorine, hydroxyl or methoxy;R is --NH--Z--X;Z is straight or branched alkylene of 1 to 6 carbon atoms or cycloalkylene of 3 to 6 carbon atoms;X is cyano, hydroxyl, mercapto, aminocarbonyl, aminosulfonyl, ##STR2## R.sub.1 is straight or branched alkyl of 1 to 4 carbon atoms or phenyl; R.sub.2 is hydrogen or alkyl of 1 to 4 carbon atoms; andR.sub.1 and R.sub.2, together with an adjacent nitrogen atom to which they are attached, form a 3- to 6-membered heterocyclic ring;and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases.
Type:
Grant
Filed:
May 14, 1980
Date of Patent:
September 15, 1981
Assignee:
Karl Thomae GmbH
Inventors:
Bernd Wetzel, Eberhard Woitun, Wolfgang Reuter, Roland Maier, Uwe Lechner, Hanns Goeth