Patents Assigned to KARMA BIOTECHNOLOGIES
  • MULTI-VESICULAR LIPID NANOPARTICLE TOLEROGENIC VACCINES FOR INDUCTION OF SYSTEMIC IMMUNE TOLERANCE IN VIVO
    Publication number: 20250064740
    Abstract: A multivesicular lipid nanoparticle composition includes a plurality of multivesicular lipids. Each multivesicular lipid nanoparticle includes a carrier phospholipid micelle including a carrier phospholipid layer and having an average diameter less than 1 micron; and at least one sub-chamber phospholipid inverse micelle including a sub-chamber phospholipid layer and having an average diameter less than 100 nm. The carrier micelle nanoparticle encapsulates the at least one sub-chamber inverse micelle nanoparticle. Characteristically, phospholipid tail groups of the carrier micelle are covalently linked to the phospholipid tail groups of at least one sub-chamber inverse micelle nanoparticle.
    Type: Application
    Filed: January 17, 2023
    Publication date: February 27, 2025
    Applicant: KARMA BIOTECHNOLOGIES
    Inventors: Andrew Brovko GRAY, Alan Michael JOHNSON, Xazmin Helen CUSTER, Mariana FIGUEIREDO UCHOA, Luciana Cecilia VEIRAS
  • Multi-vesicular liposomes for targeted delivery of drugs and biologics for tissue engineering
    Patent number: 11684579
    Abstract: A multivesicular liposome composition includes a plurality of multivesicular liposomes. Each multivesicular liposome includes a carrier liposome particle including carrier phospholipid bilayer and having an average diameter less than 1 micron; and at least one sub-chamber liposome nanoparticle including a sub-chamber liposome nanoparticle bilayer and having an average diameter less than about 50 nm. The carrier liposome particle encapsulates the at least one sub-chamber liposome nanoparticle. Characteristically, tail groups of the carrier liposome phospholipids are larger than tail groups phospholipids of the at least one sub-chamber liposome nanoparticle.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: June 27, 2023
    Assignee: KARMA BIOTECHNOLOGIES
    Inventors: Andrew Brovko Gray, Donald Dewane Johnson, Alan Michael Johnson
  • MULTI-VESICULAR LIPOSOMES FOR TARGETED DELIVERY OF DRUGS AND BIOLOGICS FOR TISSUE ENGINEERING
    Publication number: 20210186878
    Abstract: A multivesicular liposome composition includes a plurality of multivesicular liposomes. Each multivesicular liposome includes a carrier liposome particle including carrier phospholipid bilayer and having an average diameter less than 1 micron; and at least one sub-chamber liposome nanoparticle including a sub-chamber liposome nanoparticle bilayer and having an average diameter less than about 50 nm. The carrier liposome particle encapsulates the at least one sub-chamber liposome nanoparticle. Characteristically, tail groups of the carrier liposome phospholipids are larger than tail groups phospholipids of the at least one sub-chamber liposome nanoparticle.
    Type: Application
    Filed: April 29, 2019
    Publication date: June 24, 2021
    Applicant: KARMA BIOTECHNOLOGIES
    Inventors: Andrew Brovko GRAY, Donald Dewane JOHNSON, Alan Michael JOHNSON