Patents Assigned to Karolinska Innovations AB and Pharmacia & Upjohn Company
  • Novel component in the hedgehog signalling pathway
    Publication number: 20040146929
    Abstract: The present invention relates to a novel human patched-like gene (PTCH2), which for the first time has been cloned and sequenced. Several alternatively spliced mRNA forms of PTCH2 have been identified, including transcripts lacking segments thought to be involved in sonic hedgehog (SHH) binding and mRNAs with differentially defined 3′ terminal exons. Further, the invention also relates to the protein encoded by the present PTCH2 as well as to functional analogues and variants thereof.
    Type: Application
    Filed: March 4, 2004
    Publication date: July 29, 2004
    Applicant: Karolinska Innovations AB and Pharmacia & Upjohn Company
    Inventors: Peter G. Zaphiropoulos, Anne Birgitte Unden, Rune Toftgard, Fahimeh Rahnama, Robert E. Hollingsworth