Patents Assigned to Katholieke Universiteit Leuven
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Publication number: 20240144638Abstract: A method for adjusting an information system of a mobile machine, the information system being configured to calculate 3D information relative to a scene in which the mobile machine is moving, the method including: acquiring at least a first image of the scene at a first time and a second image of the scene at a second time; detecting one or more scene features in the first image and the second image; matching the one or more scene features across the first image and the second image based upon detection of the one or more scene features; estimating an egomotion of the mobile machine based upon the matching of the one or more scene features across the first image and the second image; and adjusting the information system by taking into account the estimation of the egomotion of the mobile machine.Type: ApplicationFiled: August 17, 2023Publication date: May 2, 2024Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, KATHOLIEKE UNIVERSITEIT LEUVENInventors: Wim ABBELOOS, Frank VERBIEST, Bruno DAWAGNE, Wim LEMKENS, Marc PROESMANS, Luc VAN GOOL
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Patent number: 11971385Abstract: A cyclic capillary electrophoresis device includes a capillary channel that forms a closed loop. The capillary channel comprises an inner half facing toward a space enclosed by the loop, where the inner half having an inner wall of first charge density, and an outer half facing away from the space enclosed by the loop, where the outer half having an inner wall surface of second charge density. A difference between the first and the second charge densities exists or can be turned on. The difference is configured to create a smaller average electroosmotic flow velocity in the inner half than in the outer half.Type: GrantFiled: September 11, 2020Date of Patent: April 30, 2024Assignees: Imec vzw, Katholieke Universiteit LeuvenInventors: Koen Martens, Chengxun Liu, Camila Dalben Madeira Campos, Rita Vos
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Patent number: 11962146Abstract: A system for controlling a bipolar DC power includes a positive conductor, a neutral conductor and negative conductor. A positive pole-to-neutral voltage is a voltage between the positive conductor and the neutral conductor and a negative pole-to-neutral voltage is a voltage between the negative conductor and the neutral conductor. The system comprises control means for controlling the positive pole-to-neutral voltage and the negative pole-to-neutral voltage. The control means includes a first voltage converter configured to control a sum or difference of the positive pole-to-neutral voltage and the negative pole-to-neutral voltage, respectively as a function of the sum or difference of the positive output current and negative output current, and a second voltage converter.Type: GrantFiled: March 4, 2020Date of Patent: April 16, 2024Assignee: KATHOLIEKE UNIVERSITEIT LEUVENInventors: Johan Driesen, Giel Van Den Broeck
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Patent number: 11952365Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.Type: GrantFiled: June 8, 2021Date of Patent: April 9, 2024Assignees: Aligos Therapeutics, Inc., Katholieke Universiteit LeuvenInventors: Koen Vandyck, Pierre Jean-Marie Bernard Raboisson, Leonid Beigelman, Vladimir Serebryany, Antitsa Dimitrova Stoycheva, Dorothée Alice Marie-Eve Bardiot, Sandro Boland, Arnaud Didier Marie Marchand
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Patent number: 11939324Abstract: The present invention relates to a compound of formula (I) or a tautomer thereof, wherein R1, R2, R3, R4 and R5, have the same meaning as that defined in the claims and the description. The present invention also relates to compositions, in particular pharmaceuticals, comprising such compounds, and to uses of such compounds and compositions for the prevention and/or treatment of epilepsy and/or neurodegenerative diseases.Type: GrantFiled: November 22, 2022Date of Patent: March 26, 2024Assignees: reMYND N.V., Katholieke Universiteit LeuvenInventors: Johan Gerard Griffioen, Katrien Princen, Tom Francois L. Van Dooren, Arnaud Didier Marie Marchand, Amuri Kilonda, Sara Allasia, Patrick Chaltin
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Patent number: 11931160Abstract: A brain interaction apparatus is provided. The apparatus comprises a plurality of filaments; and a brain invasive launcher having a plurality of launching channels extending in a longitudinal direction between a proximal end and a distal end thereof. Each launching channel is configured for holding one of the plurality of filaments moveably arranged therein. At least one of the plurality of filaments is provided with a steering tip affixed to a distal end thereof. The steering tip comprises a portion tapering in a longitudinal direction of the at least one of the plurality of filaments thereby narrowing toward a distal end of the steering tip. The tapered portion is rotationally asymmetrical about a longitudinal axis of the at least one of the plurality of filaments.Type: GrantFiled: May 31, 2018Date of Patent: March 19, 2024Assignees: Imec vzw, Katholieke Universiteit Leuven, VIBInventors: Sebastian Haesler, Luis Diego Leon Hoffman
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Patent number: 11918609Abstract: The present invention provides a method for treating wounds by applying cells as described in this application. In one aspect the method provides treatment for cutaneous wounds. In general embodiments the cells are delivered to the wound without being attached to a functionalized substrate in the delivery vehicle.Type: GrantFiled: April 5, 2021Date of Patent: March 5, 2024Assignees: ABT HOLDING COMPANY, KATHOLIEKE UNIVERSITEIT LEUVENInventors: Aernout Luttun, Robert J. Deans
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Patent number: 11923198Abstract: In a first aspect, the present disclosure relates to a method for forming a patterning mask over a layer to be patterned, the method comprising: (a) providing a first layer over a substrate, the substrate comprising the layer to be patterned, the first layer being capable to bond with a monolayer comprising a compound comprising a functional group for bonding to the first layer and a removable organic group, (b) bonding the monolayer to the first layer, (c) exposing the monolayer to an energy beam, thereby forming a pattern comprising a first area comprising the compound with the removable organic group and a second area comprising the compound not having the removable organic group, and (d) selectively depositing an amorphous carbon layer on top of the first area.Type: GrantFiled: April 12, 2021Date of Patent: March 5, 2024Assignees: IMEC VZW, Katholieke Universiteit Leuven, KU LEUVEN R&DInventors: Mikhail Krishtab, Silvia Armini
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Patent number: 11918548Abstract: The invention relates to vascular disrupting agent (VDA) such as combretastatins for treating avascular or hypovascular micro-tumors with a diameter below 20 mm.Type: GrantFiled: July 4, 2018Date of Patent: March 5, 2024Assignee: Katholieke Universiteit LeuvenInventor: Yicheng Ni
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Patent number: 11910725Abstract: The present disclosure relates to magnetic devices. In particular, the disclosure relates to magnetic memory and logic devices that employ the voltage control of magnetic anisotropy (VCMA) effect for magnetization switching. The present disclosure provides a method for manufacturing a magnetic structure for such a magnetic device. The method comprising the following steps: providing a bottom electrode layer, forming a SrTiO3 (STO) stack on the bottom electrode layer by atomic layer deposition (ALD) of at least two different STO nanolaminates, forming a magnetic layer on the STO stack, and forming a perpendicular magnetic anisotropy (PMA) promoting layer on the magnetic layer, the PMA promoting layer being configured to promote PMA in the magnetic layer.Type: GrantFiled: December 14, 2020Date of Patent: February 20, 2024Assignees: IMEC VZW, Katholieke Universiteit LeuvenInventors: Bart Vermeulen, Mihaela Ioana Popovici, Koen Martens, Gouri Sankar Kar
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Patent number: 11904413Abstract: Sensor values captured by a sensor device are determined, one or more regions of a three-dimensional component having a deviation from an intended value are determined based at least in part on build coordinates for additively manufacturing the three-dimensional component corresponding to the sensor values, and a quality of the three-dimensional component is evaluated based at least in part on the one or more regions of the three-dimensional component having a deviation from the intended value. The sensor values correspond to an electromagnetic spectrum emitted by a melt pool formed by exposing a powder bed to a beam of radiation emitted from a laser apparatus, with the beam of radiation generating the melt pool in a melt region of the powder bed.Type: GrantFiled: March 7, 2022Date of Patent: February 20, 2024Assignees: Concept Laser GmbH, Katholieke Universiteit LeuvenInventors: Frank Herzog, Florian Bechmann, Sebastian Berumen, Jean Pierre Kruth, Tom Craeghs
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Publication number: 20240055013Abstract: A method of estimating speech intelligibility is disclosed. The method comprises the steps of providing at least a first time-dependent signal derived from a first auditory stimulus and a corresponding first measured EEG response; comparing at least part of the first signal with at least part of the first measured EEG response in order to determine a signal-response latency difference; comparing the signal-response latency difference to a reference value; and deriving a measure of speech intelligibility based on the comparison of the signal-response latency difference and the reference value.Type: ApplicationFiled: October 2, 2020Publication date: February 15, 2024Applicants: Katholieke Universiteit Leuven, Universidad de la RepublicaInventors: Francisco Cervantes Constantino, Tom Francart, Jonas Vanthornhout
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Patent number: 11900696Abstract: A system and a method for processing a plurality of images, each image of the plurality of images being acquired by a respective image acquisition module of a vehicle and each image acquisition module being oriented outwardly with respect to the vehicle, the method comprising: elaborating a bird's eye view image of surroundings of the vehicle using pixel values of pixels of at least one portion of each image of the plurality of images as pixel values of the bird's eye view image, and performing, on the bird's eye view image, a detection of at least one lane marked on a surface on which the vehicle is and visible on the bird's eye view image.Type: GrantFiled: August 28, 2019Date of Patent: February 13, 2024Assignees: TOYOTA MOTOR EUROPE, KATHOLIEKE UNIVERSITEIT LEUVENInventors: Kazuki Tamura, Hiroaki Shimizu, Marc Proesmans, Frank Verbiest, Jonas Heylen, Bruno Dawagne, Davy Neven, Bert Debrabandere, Luc Van Gool
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Patent number: 11900987Abstract: The disclosed technology relates to a non-volatile (NV) static random-access memory (SRAM) device, and to a method of operating the same. The NV-SRAM device includes a plurality of bit-cells, wherein each bit-cell comprises: an SRAM bit-cell; a first bit-line connected via a first access element to the SRAM bit-cell; a NV bit-cell connected via a switch to the SRAM bit-cell; and a second bit-line connected via a second access element to the NV bit-cell. The NV-SRAM device is configured to independently write data from the first bit-line into the SRAM bit-cell through the first access element, and respectively from the second bit-line into the NV bit-cell through the second access element.Type: GrantFiled: November 18, 2020Date of Patent: February 13, 2024Assignees: IMEC vzw, Katholieke Universiteit LeuvenInventors: Mohit Gupta, Manu Komalan Perumkunnil
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Publication number: 20240044881Abstract: Described herein are nanopore biosensors based on a modified cytolysin protein. The nanopore biosensors accommodate macromolecules including proteins and nucleic acids, and may additionally comprise ligands with selective binding properties.Type: ApplicationFiled: August 2, 2023Publication date: February 8, 2024Applicant: Katholieke Universiteit LeuvenInventors: Giovanni Maglia, Mikhael Soskine
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Method and system for processing an image and performing instance segmentation using affinity graphs
Patent number: 11881016Abstract: A system and a method for processing an image so as to perform instance segmentation. The system/method includes: a—inputting (S1) the image (IMG) to a first neural network configured to output an affinity graph (AF), and b—inputting (S2), to a second neural network, the affinity graph and a predefined seed-map (SM), so as to determine whether other pixels belong to a same instance, and set at a first value the value of the other pixels determined as belonging to the same instance.Type: GrantFiled: September 21, 2018Date of Patent: January 23, 2024Assignees: TOYOTA MOTOR EUROPE, KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&DInventors: Hiroaki Shimizu, Bert De Brabandere, Davy Neven, Marc Proesmans, Luc Van Gool -
Patent number: 11872262Abstract: The present invention relates to non-naturally occurring anti-bacterial peptides. More specifically the peptides can be used to treat multi-drug resistant bacterial infections. In addition, the present invention provides methods for producing anti-bacterial peptides.Type: GrantFiled: May 9, 2018Date of Patent: January 16, 2024Assignees: VIB VZW, Katholieke Universiteit Leuven, K.U. Leuven R&DInventors: Joost Schymkowitz, Frederic Rousseau
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Patent number: 11864876Abstract: A light-to-digital converter (2) comprises a light-to-current converter (10); a current integrator (4) with an integrator output (30) resettable to a baseline level; and a counter (18) with a digital output (26), wherein the light-to-current converter (10) is switchably connectable as a positive integration input to the current integrator (4), for, during a light-collecting phase (404-406), integrating a current from the light-to-current converter (10), the integrator output (30) starting from the baseline value and ending at a value to be digitized; a reference current source (14) is switchably connectable as a negative integration input to the current integrator (4), for, during a counting phase (406-408) subsequent to the light-collecting phase (404-406), integrating a reference current from the reference current source (14), the integrator output (30) starting from the value to be digitized and ending at the baseline value, the time spent integrating the reference current corresponding to the value to beType: GrantFiled: May 28, 2020Date of Patent: January 9, 2024Assignees: IMEC VZW, KATHOLIEKE UNIVERSITEIT LEUVEN KU LEUVEN, STICHTING IMEC NEDERLANDInventors: Qiuyang Lin, Jiawei Xu, Shuang Song, Nick Van Helleputte, Filip Tavernier
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Publication number: 20230414570Abstract: Provided herein are compositions for topical use comprising an imidazole or a salt thereof, and domiphen bromide as active ingredients for use in treating or preventing a fungal infection, wherein said imidazole is chosen from ketoconazole and clotrimazole as active ingredients for use in treating or preventing a fungal infection.Type: ApplicationFiled: September 13, 2023Publication date: December 28, 2023Applicants: Katholieke Universiteit Leuven, Universiteit AntwerpenInventors: Bruno Cammue, Karin Thevissen, Kaat De Cremer, Paul Cos
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Patent number: 11851422Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.Type: GrantFiled: July 6, 2022Date of Patent: December 26, 2023Assignees: Katholieke Universiteit LeuvenInventors: Koen Vandyck, Dorothée Alice Marie-Eve Bardiot, Pierre Jean-Marie Bernard Raboisson, Leonid Beigelman, Antitsa Dimitrova Stoycheva, Sandro Boland, Arnaud Didier Marie Marchand