Patents Assigned to Katholieke Universiteit Leuven
  • Prebiotic Oral Care Compositions Containing Carboxylic Acids
    Publication number: 20210251862
    Abstract: The present invention provides an oral care composition comprising a carboxylic acid of the formula: wherein: R1 is H, or is a substituted or unsubstituted alkyl group; and R2 is H, OH, or NH2; for use in: (a) selectively promoting, in an oral cavity: growth, metabolic activity or colonization of bacteria that have beneficial effects on oral health, relative to growth, metabolic activity or colonization of pathogenic oral bacteria; (b) selectively promoting, in an oral cavity, biofilm formation by bacteria that have beneficial effects on oral health, relative to biofilm formation by pathogenic oral bacteria; or (c) maintaining and/or re-establishing a healthy oral microflora.
    Type: Application
    Filed: February 9, 2021
    Publication date: August 19, 2021
    Applicants: Colgate-Palmolive Company, Katholieke Universiteit Leuven, Universiteit Gent
    Inventors: Hans Stettler, Wim Teughels, Marc Quirynen, Nico Boon
  • Method for preparing an asymmetric membrane
    Patent number: 11083999
    Abstract: The present invention provides a method for the preparation of an asymmetric membranes. More particularly, the new method relates to the use of a crosslinker contacted via vapour or liquid phase with the surface layer of a cast polymer film, followed by the immersion of said film in a coagulation bath. The formation of a crosslinked skin layer and the solidification of the membrane bulk can thus be decoupled in time.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: August 10, 2021
    Assignee: Katholieke Universiteit Leuven
    Inventors: Sanne Hermans, Ivo Vankelecom, Annelies Van Sieleghem
  • Substituted indoline derivatives as dengue viral replication inhibitors
    Patent number: 11083707
    Abstract: The present invention relates to substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: August 10, 2021
    Assignees: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Jean-François Bonfanti, Erwin Coesemans, Pierre Jean-Marie Bernard Raboisson, Arnaud Didier M Marchand, Dorothée Alice Marie-Eve Bardiot
  • Smoothed doped layer for solar cell
    Patent number: 11075317
    Abstract: The disclosed technology generally relates to silicon solar cells and more particularly to a doped layer formed on a textured surface of a silicon solar cell, and methods of fabricating the same. In one aspect, a method of creating a doped layer at a rear side of a crystalline silicon bifacial solar cell is disclosed. The method can include texturing at least a rear side of a silicon substrate of the solar cell to create a pattern of pyramids, thereby creating a pyramidal topology of the rear side. The method can also include forming a doped layer at the rear side by, using epitaxial growth, growing at least one doped silicon epitaxial layer on the pyramids. Simultaneously with forming the doped layer and by using facet evolution, the pyramidal topology of the rear side can be smoothed by the growth of the at least one epitaxial layer.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: July 27, 2021
    Assignees: IMEC vzw, Katholieke Universiteit Leuven
    Inventors: Yuandong Li, Filip Duerinckx, Maria Jesus Recaman Payo, Jef Poortmans
  • Quantum bits by electrostatic gating superconducting rings
    Patent number: 11055625
    Abstract: The disclosed technology generally relates to superconducting devices, and more particularly to superconducting rings, qubits comprising the superconducting rings and methods of coherently coupling flux states of the superconducting rings. In one aspect, a qubit includes a superconducting ring around a hole. The qubit additionally includes an electric field generator adapted for applying an electric field in a plane of the superconducting ring over at least part of the superconducting ring, and a magnetic field generator adapted for applying a magnetic field component orthogonal to the plane of the superconducting ring such that the magnetic field component at least crosses the hole of the ring.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: July 6, 2021
    Assignees: IMEC vzw, Katholieke Universiteit Leuven
    Inventors: Ahmed Kenawy, Bart Soree, Wim Magnus
  • Method and device for thermal insulation of micro-reactors
    Patent number: 11052387
    Abstract: A micro-fluidic device is described. The micro-fluidic device includes a semiconductor substrate; at least one micro-reactor in the semiconductor substrate; one or more micro-fluidic channels in the semiconductor substrate, connected to the at least one micro-reactor; a cover layer bonded to the semiconductor substrate for sealing the one or more micro-fluidic channels; and at least one through-substrate trench surrounding the at least one micro-reactor and the one or more micro-fluidic channels.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: July 6, 2021
    Assignees: IMEC VZW, Katholieke Universiteit Leuven, KU LEUVEN R&D, Panasonic Corporation
    Inventors: Ben Jones, Paolo Fiorini, Hiroyuki Tanaka
  • NON-FIRED MONOLITHS
    Publication number: 20210198144
    Abstract: The invention relates to methods for manufacturing an inorganic polymer object from a precursor wherein the precursor consists of one or more or comprises one or more selected from the group consisting of gibbsite-containing bauxite, gibbsite containing residue of the Bayer process, thermally processed gibbsite-containing bauxite, and thermally processed gibbsite-containing residue of the Bayer process, the method comprising the steps of alkaline-activating said precursor, mixing the precursor, shaping the mixed precursor and hydrothermally curing the shaped precursor at a temperature between 70° C. and 350° C.
    Type: Application
    Filed: October 11, 2018
    Publication date: July 1, 2021
    Applicant: KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Tobias HERTEL, Yiannis PONTIKES
  • Prodrugs of nucleoside phosphonates
    Patent number: 11040047
    Abstract: The present invention relates to novel phosphonoamidate prodrugs. The invention also relates to the use of these novel phosphonate-modified nucleosides to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses such as the herpes simplex virus 1, herpes simplex virus 2, human cytomegalovirus, varicella zoster virus, vaccinia virus and adenovirus.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: June 22, 2021
    Assignee: Katholieke Universiteit Leuven
    Inventors: Graciela Andrei, Steven De Jonghe, Elisabetta Groaz, Piet Herdewijn, Min Luo, Dominique Schols, Robert Snoeck
  • MONO- OR DI-SUBSTITUTED INDOLE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS
    Publication number: 20210171462
    Abstract: The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using the compounds and also relates to use of the compounds as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Application
    Filed: December 31, 2020
    Publication date: June 10, 2021
    Applicants: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Jean-François Bonfanti, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand
  • Treatment of central nervous tumours
    Patent number: 11007154
    Abstract: The present invention generally relates to a new formulation containing nanoparticles encapsulating siRNA for the use of RNAi technology for gene silencing of galectin-1 involved in tumour progression. More in particular the present invention relates to the use of RNAi molecules for treating central nervous cancer, more in particular for treating glioblastoma multiforme (GBM).
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: May 18, 2021
    Assignees: KATHOLIEKE UNIVERSITEIT LEUVEN, UNIVERSITÉ LIBRE DE BRUXELLES
    Inventors: Steven De Vleeschouwer, Matthias Van Woensel, Karim Amighi, Nathalie Wauthoz, Rémi Rosiere
  • Method for detecting or quantifying carbon black and/or black carbon particles
    Patent number: 11002679
    Abstract: A method for detecting the presence of or quantification of carbon black and/or black carbon in a sample or carrier medium. The method includes providing the sample or carrier medium without labelling or pre-treatment of the carbon black and/or black carbon particles; illuminating the sample or carrier medium at a temperature below 90° C. by a pulsed light with a pulse duration below 500 femtoseconds, a repetition rate above 1 MHz with an average power below 20 mW, and a wavelength of a femtosecond laser pulse ranging from 700 to 1200 nm, to generate non-incandescence related light emission from the carbon black and/or black carbon particles; and analysis of the light emission.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: May 11, 2021
    Assignees: Katholieke Universiteit Leuven, Universiteit Hasselt
    Inventors: Marcel Ameloot, Hannelore Bové, Tim Nawrot, Maarten Roeffaers, Christian Steuwe, Martin Vandeven
  • Spin orbit torque magnetoresistive random access memory device
    Patent number: 11004490
    Abstract: The disclosed technology relates generally to magnetic random access memory, and more particularly to spin-orbit-torque (SOT) magnetoresistive random access memory (MRAM). According to an aspect, a MRAM device comprises a first transistor, a second transistor, and a resistive memory element. The resistive memory element comprises a magnetic tunnel junction (MTJ) pillar arranged between a top electrode and bottom electrode having a first terminal and a second terminal. According to another aspect, a method of using the MRAM device is disclosed.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: May 11, 2021
    Assignees: IMEC vzw, Katholieke Universiteit Leuven
    Inventors: Sushil Sakhare, Kevin Garello, Mohit Gupta, Manu Komalan Perumkunnil
  • COMPOSITIONS COMPRISING ADAMTS13 FOR USE IN METHODS FOR THE RECANALIZATION OF OCCLUDED BLOOD VESSELS IN AN INFARCTION
    Publication number: 20210128701
    Abstract: Provided herein are methods for recanalization of occluded blood vessels in a subject having an infarction. The method includes a step of administering to the subject a therapeutically effective amount of isolated ADAMTS13 protein at particular dosages and ranges of times after detection of the infarction. As described herein, ADAMTS13 advantageously recanalizes occluded blood vessels and reduces infarction size, even when administered a prolonged period after stable occlusion. Accordingly, such methods and compositions are useful for the treatment of infractions caused by blood vessel occlusion.
    Type: Application
    Filed: October 3, 2019
    Publication date: May 6, 2021
    Applicants: Baxalta Incorporated, Baxalta GmbH, Katholieke Universiteit Leuven
    Inventors: Barbara PLAIMAUER, Hanspeter Rottensteiner, Friedrich Scheiflinger, Simon De Meyer, Frederik Denorme
  • METHOD FOR THE TREATMENT OF DRAVET SYNDROME
    Publication number: 20210121479
    Abstract: A method of treating and/or preventing Dravet Syndrome in a patient such as a patient previously diagnosed with Dravet Syndrome, by administering an effective dose of fenfluramine or its pharmaceutically acceptable salt to that patient. Dravet Syndrome patients are typically children under the age of 18 and are treated at a preferred dose of less than about 0.5 to about 0.01 mg/kg/day.
    Type: Application
    Filed: June 12, 2020
    Publication date: April 29, 2021
    Applicants: KATHOLIEKE UNIVERSITEIT LEUVEN, UNIVERSITY HOSPITAL ANTWERP
    Inventors: Berten CEULEMENS, Lieven LAGAE
  • Immunotherapy targeting intracellular pathogens
    Patent number: 10982196
    Abstract: The present invention relates to the use of immunogenic peptides comprising a T-cell epitope derived from an intracellular pathogen-associated antigen and a redox motif such as C-(X)2-[CST] or [CST]-(X)2-C in the prevention and/or treatment of infection with an intracellular pathogen and in the manufacture of medicaments therefore.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: April 20, 2021
    Assignees: Life Sciences Research Partners VZW, Katholieke Universiteit Leuven
    Inventor: Jean-Marie Saint-Remy
  • Nanopore biosensors for detection of proteins and nucleic acids
    Patent number: 10976311
    Abstract: Described herein are nanopore biosensors based on a modified cytolysin protein. The nanopore biosensors accommodate macromolecules including proteins and nucleic acids, and may additionally comprise ligands with selective binding properties.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: April 13, 2021
    Assignee: Katholieke Universiteit Leuven
    Inventors: Giovanni Maglia, Mikhael Soskine
  • Modified nanopores, compositions comprising the same, and uses thereof
    Patent number: 10976300
    Abstract: Provided herein relate to modified or mutant forms of cytolysin A (ClyA) and compositions comprising the same. In particular, the modified or mutant forms of ClyA permits efficient capture and/or translocation of a target negative-charged molecule or polymer through the modified or mutant ClyA nanopores at low or physiological ionic strengths. Thus, methods for using the modified or mutant forms of ClyA and compositions, for example, for characterizing a target negatively-charged analyte, e.g., a target polynucleotide, are also provided.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: April 13, 2021
    Assignee: Katholieke Universiteit Leuven
    Inventors: Giovanni Maglia, Lorenzo Franceschini, Tine Brouns, Andrew John Heron, Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace
  • Stem cells for wound healing
    Patent number: 10967006
    Abstract: The present invention provides a method for treating wounds by applying cells as described in this application. In one aspect the method provides treatment for cutaneous wounds. In general embodiments the cells are delivered to the wound without being attached to a functionalized substrate in the delivery vehicle.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: April 6, 2021
    Assignees: ABT Holding Company, Katholieke Universiteit Leuven
    Inventors: Aernout Luttun, Robert J Deans
  • Simulation of photovoltaic systems
    Patent number: 10963603
    Abstract: A method for generating/updating a database of current-voltage characteristic curves is disclosed. This method includes simulating for at least one combination of a topology of a photovoltaic cell group, an internal cell temperature(s) and a cell irradiation(s), a model of the photovoltaic cell group to provide a representative current-voltage characteristic curve, and clustering the current-voltage characteristic curves to identify at least one plurality of similar current-voltage characteristic curves.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: March 30, 2021
    Assignees: Imec vzw, Katholieke Universiteit Leuven, KU Leuven R&D
    Inventors: Francky Catthoor, Maria-Iro Baka, Patrizio Manganiello
  • Therapeutically active pyrazolo-pyrimidine derivatives
    Patent number: RE48622
    Abstract: A series of pyrazolo[3,4-d]pyrimidine derivatives that are substituted at the 4-position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.
    Type: Grant
    Filed: July 22, 2019
    Date of Patent: July 6, 2021
    Assignees: UCB Biopharma SRL, Katholieke Universiteit Leuven, K.U. Leuven R&D
    Inventors: Daniel James Ford, Richard Jeremy Franklin, Anant Ramrao Ghawalkar, Helen Tracey Horsley, Qiuya Huang, James Thomas Reuberson, Bart Vanderhoydonck