Abstract: A recombinant human monoclonal pentameric IgM antibody comprising the capability of oligospecific binding to purified ganglioside epitopes GD3, GM3, GD2 and GM1 and the capability of specific binding to malignant cancer cells selected from the group consisting of melanoma cells, small cell lung cancer cells, glioblastoma cells, and estrogen receptor-negative metastatic breast cancer cells; a cell line producing the IgM antibody; and the use of the IgM antibody as a diagnostic tool and/or as a therapeutic agent.
Type:
Grant
Filed:
February 8, 2018
Date of Patent:
March 17, 2020
Assignee:
KATINGER GMBH
Inventors:
Hermann Katinger, Renate Kunert, Thomas Sterovsky, Thomas Hemetsberger
Abstract: A recombinant human monoclonal pentameric IgM antibody comprising the capability of oligospecific binding to purified ganglioside epitopes GD3, GM3, GD2 and GM1 and the capability of specific binding to malignant cancer cells selected from the group consisting of melanoma cells, small cell lung cancer cells, glioblastoma cells, and estrogen receptor-negative metastatic breast cancer cells; a cell line producing the IgM antibody; and the use of the IgM antibody as a diagnostic tool and/or as a therapeutic agent.
Type:
Grant
Filed:
November 26, 2013
Date of Patent:
March 20, 2018
Assignee:
KATINGER GMBH
Inventors:
Hermann Katinger, Renate Kunert, Thomas Sterovsky, Thomas Hemetsberger
Abstract: A recombinant human monoclonal pentameric IgM antibody comprising the capability of oligospecific binding to purified ganglioside epitopes GD3, GM3, GD2 and GM1 and the capability of specific binding to malignant cancer cells selected from the group consisting of melanoma cells, small cell lung cancer cells, glioblastoma cells, and estrogen receptor-negative metastatic breast cancer cells; a cell line producing the IgM antibody; and the use of the IgM antibody as a diagnostic tool and/or as a therapeutic agent.
Type:
Application
Filed:
November 26, 2013
Publication date:
November 12, 2015
Applicant:
Katinger GmbH
Inventors:
Hermann KATINGER, Renate KUNERT, Thomas STEROVSKY, Thomas HEMETSBERGER