Patents Assigned to Kazunori Kataoka
  • Patent number: 6090317
    Abstract: This invention provides a heterotelechelic oligomer or polymer which is represented by the following formula: ##STR1## wherein A denotes a sugar residue, L denotes a linkage group represented by the following formula ##STR2## wherein R.sup.1 and R.sup.2 independently denote lower alkyl, aralkyl or aryl,X denotes a single bond or --CH.sub.2 CH.sub.2 --, Z denotes a group forming an unsaturated ester or ether, or a functional group such as halogen which binds to --CH.sub.2 CH.sub.2 --, n denotes an integer of 5-10,000, and m denotes an integer of 0 or 2-10,000.This invention also provides a process to produce the above oligomer or polymer, and further a high molecular-micelle with use of a polyethylene oxide-polyester block polymer which has a sugar residue at its terminal. Said oligomer or polymer is expected to exhibit excellent bioavailability, and is also expected to be utilized in the field such as carriers for drug delivery or diagnostic reagents.
    Type: Grant
    Filed: July 27, 1999
    Date of Patent: July 18, 2000
    Assignee: Kazunori Kataoka
    Inventors: Kazunori Kataoka, Yukio Nagasaki, Masao Kato, Teruo Okano, Teruo Nakamura
  • Patent number: 5973069
    Abstract: This invention provides a heterotelechelic oligomer or polymer which is represented by the following formula: ##STR1## wherein A denotes a sugar residue, L denotes a linkage group represented by the following formula ##STR2## wherein R.sup.1 and R.sup.2 independently denote lower alkyl, aralkyl or aryl,X denotes a single bond or --CH.sub.2 CH--, Z denotes a group forming an unsaturated ester or ether, or a functional group such as halogen which binds to --CH.sub.2 CH.sub.2 --, n denotes an integer of 5-10,000, and m denotes an integer of 0 or 2-10,000.This invention also provides a process to produce the above oligomer or polymer, and further a high molecular-micelle with use of a polyethylene oxide-polyester block polymer which has a sugar residue at its terminal. Said oligomer or polymer is expected to exhibit excellent bioavailability, and is also expected to be utilized in the field such as carriers for drug delivery or diagnostic reagents.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: October 26, 1999
    Assignee: Kazunori Kataoka
    Inventors: Kazunori Kataoka, Yukio Nagasaki, Masao Kato, Teruo Okano, Teruo Nakamura
  • Patent number: 5929177
    Abstract: The present invention provides a block polymer which has functional groups on its both ends, and which comprises hydrophilic/hydrophobic segments. As for the functional groups on its both ends, the block polymer has amino group, carboxyl group or mercapto group on .alpha.-terminal, and hydroxyl group, carboxyl group, aldehyde group or vinyl group on .omega.-terminal. Hydrophilic segment comprises polyethylene oxide, while hydrophobic segment is derived from lactide, lactone or (meth)acrylic acid ester. The block polymer of this invention forms a polymeric micelle which is usable as bio-compatible materials.
    Type: Grant
    Filed: February 5, 1998
    Date of Patent: July 27, 1999
    Assignee: Kazunori Kataoka
    Inventors: Kazunori Kataoka, Masao Kato, Yukio Nagasaki, Teruo Okano
  • Patent number: 5925720
    Abstract: This invention provides a heterotelechelic oligomer or polymer which is represented by formula below: ##STR1## wherein R.sup.1 and R.sup.2 form an acetal, or, combined with each other, denote oxy (.dbd.O),p, m, n and q each denote a certain integer,L is a group which forms an ester, andZ denotes a certain functional group.This invention a so provides a process to produce the above oligomer or polymer by means of living polymeri-zation. Since this oligomer or polymer forms a high- molecular micelle which is stable in an aqueous solvent, said oligomer or polymer will be useful as a carrier for drug delivery.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: July 20, 1999
    Assignee: Kazunori Kataoka
    Inventors: Kazunori Kataoka, Carmen Scholz, Michihiro Iijima, Takahito Kutsuna, Yukio Nagasaki, Masao Kato, Teruo Okano