Patents Assigned to Kazuo Sugamura
  • Human IL-2 receptor .gamma.-chain molecule antibody
    Patent number: 5889160
    Abstract: The present invention relates to an IL-2 receptor .gamma. chain molecule, a DNA-sequence encoding the IL-2 receptor .gamma. chain molecule, a vector possessing said DNA-sequence, a cell transformed with said vector, a method for the production of an IL-2 receptor .gamma. chain molecule by culturing of said cell, an immune response regulatory agent comprising an IL-2 receptor .gamma. chain molecule and an antibody to an IL-2 receptor .gamma. chain molecule.
    Type: Grant
    Filed: July 30, 1997
    Date of Patent: March 30, 1999
    Assignees: Ajinomoto Co., Inc., Kazuo Sugamura
    Inventors: Kazuo Sugamura, Toshikazu Takeshita, Hironobu Asao, Masataka Nakamura, Toshiro Shimamura, Manabu Suzuki, Junji Hamuro
  • .gamma.-chain humaninterleukin-2 receptor polypeptide and method of making
    Patent number: 5856140
    Abstract: A polypeptide which specifically binds to the .gamma.-chain of the human interleukin-2 receptor and selectively inhibits the binding of the .gamma.-chain of human interleukin-2 receptor to the .beta.-chain of the same is provided. The polypeptide has an activity of blocking the human interleukin-2 response. Also provided are an immunosuppressant containing the polypeptide, a DNA gene coding for the polypeptide, a recombinant DNA having the gene, a transformant having the recombinant DNA, and a method for producing the intended polypeptide by incubating the transformant. The novel polypeptide can be used independently, or with substances capable of inhibiting the binding of interleukin-2 to the interleukin-2 receptor, as a medicine for preventing the rejection of grafts after transplantation and also for curing inflammatory diseases such as allergic diseases and autoimmune diseases.
    Type: Grant
    Filed: April 24, 1996
    Date of Patent: January 5, 1999
    Assignees: Ajinomoto Co., Inc., Kazuo Sugamura
    Inventors: Toshiro Shimamura, Junji Hamuro, Harumi Nakazawa, Yuka Kanayama, Kazuo Sugamura, Toshikazu Takeshita
  • Human IL-2 receptor .gamma. chain molecule
    Patent number: 5705608
    Abstract: The present invention relates to an IL-2 receptor .gamma. chain molecule, a DNA-sequence encoding the IL-2 receptor .gamma. chain molecule, a vector possessing said DNA-sequence, a cell transformed with said vector, a method for the production of an IL-2 receptor .gamma. chain molecule by culturing of said cell, an immune response regulatory agent comprising an Il-2 receptor .gamma. chain molecule and an antibody to an IL-2 receptor .gamma. chain molecule.Both the Il-2 receptor .gamma. chain molecule and the antibody to the IL-2 receptor .gamma. chain molecule are very useful immune response regulatory agents.
    Type: Grant
    Filed: February 6, 1996
    Date of Patent: January 6, 1998
    Assignees: Ajinomoto Co., Inc., Kazuo Sugamura
    Inventors: Kazuo Sugamura, Toshikazu Takeshita, Hironobu Asao, Masataka Nakamura, Toshiro Shimamura, Manabu Suzuki, Junji Hamuro
  • Monoclonal antibodies which bind the gamma chain of human interleukin-2 receptor
    Patent number: 5582826
    Abstract: A polypeptide which specifically binds to the .gamma.-chain of the human interleukin-2 receptor and selectively inhibits the binding of the .gamma.-chain of human interleukin-2 receptor to the .beta.-chain of the same is provided. The polypeptide has an activity of blocking the human interleukin-2 response. Also provided are an immunosuppressant containing the polypeptide, a DNA gene coding for the polypeptide, a recombinant DNA having the gene, a transformant having the recombinant DNA, and a method for producing the intended polypeptide by incubating the transformant. The novel polypeptide can be used independently, or with substances capable of inhibiting the binding of interleukin-2 to the interleukin-2 receptor, as a medicine for preventing the rejection of grafts after transplantation and also for curing inflammatory diseases such as allergic diseases and autoimmune diseases.
    Type: Grant
    Filed: April 21, 1994
    Date of Patent: December 10, 1996
    Assignees: Ajinomoto Co., Inc., Kazuo Sugamura
    Inventors: Toshiro Shimamura, Junji Hamuro, Harumi Nakazawa, Yuka Kanayama, Kazuo Sugamura, Toshikazu Takeshita
  • Human IL-2 receptor .gamma. chain molecule
    Patent number: 5510259
    Abstract: The present invention relates to an IL-2 receptor .gamma. chain molecule, a DNA-sequence encoding the IL-2 receptor .gamma. chain molecule, a vector possessing said DNA-sequence, a cell transformed with said vector, a method for the production of an IL-2 receptor .gamma. chain molecule by culturing of said cell, an immune response regulatory agent comprising an Il-2 receptor .gamma. chain molecule and an antibody to an IL-2 receptor .gamma. chain molecule.Both the Il-2 receptor .gamma. chain molecule and the antibody to the IL-2 receptor .gamma. chain molecule are very useful immune response regulatory agents.
    Type: Grant
    Filed: April 22, 1993
    Date of Patent: April 23, 1996
    Assignees: Ajinomoto Co., Inc., Kazuo Sugamura
    Inventors: Kazuo Sugamura, Toshikazu Takeshita, Hironobu Asao, Masataka Nakamura, Toshiro Shimamura, Manabu Suzuki, Junji Hamuro