Patents Assigned to Kazusa DNA Research Institute
-
Publication number: 20250034207Abstract: Peptides, salts thereof, peptide conjugates, and salts thereof having 5 to 15 amino acids and having an amino acid sequence comprising at least 5 consecutive amino acids from the amino acid sequence LSSTQAQQSX1 (SEQ ID) NO: 34).Type: ApplicationFiled: February 22, 2024Publication date: January 30, 2025Applicants: Kyoto University, Kazusa DNA Research InstituteInventors: Kousaku Ohinata, Yukiha Mori, Hideyuki Suzuki
-
Publication number: 20240166686Abstract: The present invention provides peptides, salts thereof, peptide conjugates, and salts thereof having an anxiolytic-like effect, for example a peptide comprising any amino acid sequence selected from (i) an amino acid sequence SYLPPLTT (SEQ ID NO: 1), (ii) an amino acid sequence YHIEPV (SEQ ID NO: 2), (iii) an amino acid sequence YLLVK (SEQ ID NO: 3), (iv) an amino acid sequence SYLPPLT (SEQ ID NO: 4), (v) an amino acid sequence FLLVK (SEQ ID) NO. 5), and (vi) an amino acid sequence WLLVK (SEQ ID NO: 6).Type: ApplicationFiled: May 19, 2023Publication date: May 23, 2024Applicants: Kyoto University, Kazusa DNA Research InstituteInventors: Kousaku OHINATA, Saeko KIMURA, Hideyuki SUZUKI
-
Patent number: 11941852Abstract: A three-dimensional measurement device includes an image data receiving unit, a camera position selecting unit, a stereoscopic image selecting unit, and a camera position calculator. The image data receiving unit receives data of multiple photographic images. The photographic images are obtained by photographing a measurement target object and a random dot pattern from multiple surrounding viewpoints by use of a camera. The camera position selecting unit selects camera positions from among multiple positions of the camera. The stereoscopic image selecting unit selects the photographic images as stereoscopic images from among the photographic images that are taken from the camera positions selected by the camera position selecting unit. The camera position calculator calculates the camera position from which the stereoscopic images are taken. The selection of the camera positions is performed multiple times in such a manner that at least one different camera position is selected each time.Type: GrantFiled: February 25, 2020Date of Patent: March 26, 2024Assignee: Kazusa DNA Research InstituteInventors: Atsushi Hayashi, Nobuo Kochi, Takanari Tanabata, Sachiko Isobe
-
Publication number: 20230295702Abstract: A method of determining a limit of detection and a limit of quantitation in a nucleic acid detection test is provided, the method including, by using a container having a specific configuration, adding a negative specimen that does not contain target nucleic acids to a positive control group and adding a reagent used for a nucleic acid detection test to a negative control group and the positive control group to amplify the target nucleic acids, and determining a smallest specific copy number among specific copy numbers with a detection rate of 95% or greater in the positive control group as a limit of detection and determining a smallest specific copy number among specific copy numbers with CVln of 35% or less as a limit of quantitation in a case where the target nucleic acids are not detected in the negative control group.Type: ApplicationFiled: December 28, 2022Publication date: September 21, 2023Applicants: Ricoh Company, Ltd., Kazusa DNA Research InstituteInventors: Yuuki YONEKAWA, Hirotaka UNNO, Satoshi NAKAZAWA, Yunong JI, Sakae ITOGA
-
Publication number: 20230011813Abstract: This invention provides a peptide consisting of (i) the amino acid sequence LSSTQAQQSY (SEQ ID NO: 1), (ii) the amino acid sequence LSSTQAQQSW (SEQ ID NO: 6), or (iii) the amino acid sequence LSSTQAQQSF (SEQ ID NO: 7).Type: ApplicationFiled: April 12, 2022Publication date: January 12, 2023Applicants: Kyoto University, Kazusa DNA Research InstituteInventors: Kousaku Ohinata, Yukiha Mori, Hideyuki Suzuki
-
Publication number: 20220215585Abstract: A three-dimensional measurement device includes an image data receiving unit, a camera position selecting unit, a stereoscopic image selecting unit, and a camera position calculator. The image data receiving unit receives data of multiple photographic images. The photographic images are obtained by photographing a measurement target object and a random dot pattern from multiple surrounding viewpoints by use of a camera. The camera position selecting unit selects camera positions from among multiple positions of the camera. The stereoscopic image selecting unit selects the photographic images as stereoscopic images from among the photographic images that are taken from the camera positions selected by the camera position selecting unit. The camera position calculator calculates the camera position from which the stereoscopic images are taken. The selection of the camera positions is performed multiple times in such a manner that at least one different camera position is selected each time.Type: ApplicationFiled: February 25, 2020Publication date: July 7, 2022Applicant: Kazusa DNA Research InstituteInventors: Atsushi HAYASHI, Nobuo KOCHI, Takanari TANABATA, Sachiko ISOBE
-
Publication number: 20220194982Abstract: Peptides, salts thereof, peptide conjugates, and salts thereof having 5 to 15 amino acids and having an amino acid sequence comprising at least 5 consecutive amino acids from the amino acid sequence LSSTQAQQSX1 (SEQ ID NO:34).Type: ApplicationFiled: March 4, 2022Publication date: June 23, 2022Applicants: Kyoto University, Kazusa DNA Research InstituteInventors: Kousaku Ohinata, Yukiha Mori, Hideyuki Suzuki
-
Publication number: 20210310014Abstract: Gene expression is regulated (ON/OFF switching) by regulating the chromatin structure, and a several tens of genes (multigene) set introduced into genetically modified crops is stably expressed by the regulation. A plant recombinant gene expression regulatory platform DNA sequence comprising (1) an artificial alphoid DNA sequence having a hierarchical repetitive structure of an alphoid DNA that forms a centromere of a human chromosome and having a nucleotide sequence a part of which is replaced by a binding site of a gene expression regulator (inducer); and (2) a multigene (a plurality of genes) expression cassette sequence, wherein the artificial alphoid DNA sequence is linked to upstream (5? side) and downstream (3? side) of the cassette sequence; and a method for regulating the expression of a recombinant gene in a plant body using the sequence.Type: ApplicationFiled: August 5, 2019Publication date: October 7, 2021Applicant: KAZUSA DNA RESEARCH INSTITUTEInventors: Hiroshi MASUMOTO, Daisuke SHIBATA, Jun-ichirou OHZEKI, Koei OKAZAKI, Kazuto KUGOU, Koichiro OTAKE, Jekson ROBERTLEE
-
Publication number: 20210139954Abstract: A pretreatment kit includes a container (10) for particle manipulation, nucleic acid capture particles (70) capable of selectively binding to nucleic acid, aqueous-phase separation medium (21, 22, 23), a plurality of kinds of aqueous liquids (35, 31, 32, 38), and a nucleic acid for individual identification. The nucleic acid for individual identification is contained in at least one of the plurality of kinds of aqueous liquids or is bound onto the surfaces of the nucleic acid capture particles. The base sequence of the nucleic acid for individual identification contains an identification sequence including a base sequence noncomplementary to the nucleic acids contained in the biological sample. The pretreatment kit is used for separating nucleic acids from biological samples that contains nucleic acids and contaminants.Type: ApplicationFiled: January 22, 2021Publication date: May 13, 2021Applicants: SHIMADZU CORPORATION, KAZUSA DNA RESEARCH INSTITUTEInventors: Masaki KANAI, Hiroyuki JIKUYA, Tetsuo OHASHI, Shin NAKAMURA, Osamu OHARA
-
Patent number: 10809256Abstract: The purpose of the present invention is to provide a simple measurement tool which can rapidly measure various chemical substances contained in environments or from inside a living body by a simple or inexpensive means/method.Type: GrantFiled: October 7, 2013Date of Patent: October 20, 2020Assignee: KAZUSA DNA RESEARCH INSTITUTE FOUNDATIONInventors: Osamu Ohara, Ken Nonaka
-
Patent number: 10384174Abstract: The present invention relates to a particle manipulation method to disperse magnetic particles 70 in a liquid 35 filling up a tube container 10, wherein a circumferential direction moving step to move the magnetic particles 70 along the circumferential direction of the container 10 in the liquid 35 and in a radial direction moving step to move the magnetic particles 70 as crossing the radial direction of the container 10 in the liquid 35 are implemented repeatedly. Such manipulations can be achieved by combining rotation of the container and gravity force and magnetic field manipulations.Type: GrantFiled: November 17, 2014Date of Patent: August 20, 2019Assignees: SHIMADZU CORPORATION, KAZUSA DNA RESEARCH INSTITUTEInventors: Jun Yanagibayashi, Tetsuo Ohashi, Osamu Ohara
-
Patent number: 10280202Abstract: This invention provides a peptide consisting of (i) the amino acid sequence LSSTQAQQSY (SEQ ID NO: 1), (ii) the amino acid sequence LSSTQAQQSW (SEQ ID NO: 6), or (iii) the amino acid sequence LSSTQAQQSF (SEQ ID NO: 7).Type: GrantFiled: March 2, 2016Date of Patent: May 7, 2019Assignees: KYOTO UNIVERSITY, KAZUSA DNA RESEARCH INSTITUTEInventors: Kousaku Ohinata, Yukiha Mori, Hideyuki Suzuki
-
Publication number: 20190024142Abstract: A pretreatment kit includes a container (10) for particle manipulation, nucleic acid capture particles (70) capable of selectively binding to nucleic acid, aqueous-phase separation medium (21, 22, 23), a plurality of kinds of aqueous liquids (35, 31, 32, 38), and a nucleic acid for individual identification. The nucleic acid for individual identification is contained in at least one of the plurality of kinds of aqueous liquids or is bound onto the surfaces of the nucleic acid capture particles. The base sequence of the nucleic acid for individual identification contains an identification sequence including a base sequence noncomplementary to the nucleic acids contained in the biological sample. The pretreatment kit is used for separating nucleic acids from biological samples that contains nucleic acids and contaminants.Type: ApplicationFiled: January 18, 2017Publication date: January 24, 2019Applicants: SHIMADZU CORPORATION, KAZUSA DNA RESEARCH INSTITUTEInventors: Masaki KANAI, Hiroyuki JIKUYA, Tetsuo OHASHI, Shin NAKAMURA, Osamu OHARA
-
Patent number: 10159909Abstract: Disclosed is a particle manipulation method including steps of moving particles, which exist in a water-based liquid, into a gelled medium that is insoluble or hardly soluble in the water-based liquid in the water-based liquid, and moving the particles, which exist in the gelled medium, to the outside of the gelled medium. Preferably, the gelled medium is a gel that contains chemically crosslinking polymer. Preferably, the gelled medium has a consistency of 340 to 475. In one embodiment, the movement of the particles existing in the water-based liquid to the gelled medium and the movement of the particles existing inside the gelled medium to the water-based liquid are carried out inside a device, the device being loaded with a plurality of water-based liquids and a gelled medium interposed among the water-based liquids.Type: GrantFiled: July 3, 2013Date of Patent: December 25, 2018Assignees: SHIMADZU CORPORATION, KAZUSA DNA RESEARCH INSTITUTEInventors: Tetsuo Ohashi, Osamu Ohara, Ken Nonaka
-
Patent number: 9963692Abstract: The thermostable cellobiohydrolase of the present invention is a polypeptide which has cellobiohydrolase activity at least under conditions of a temperature of 75° C. and a pH of 5.5, and which includes a polypeptide including an amino acid sequence represented by SEQ ID NO: 1, 3, 5, or 7, a polypeptide including an amino acid sequence in which one or several amino acids are deleted, substituted, or added in an amino acid sequence represented by SEQ ID NO: 1, 3, 5, or 7, or a polypeptide including an amino acid sequence having 80% or greater but less than 100% sequence identity with an amino acid sequence represented by SEQ ID NO: 1, 3, 5, or 7.Type: GrantFiled: March 27, 2014Date of Patent: May 8, 2018Assignees: Honda Motor Co., Ltd., Kazusa DNA Research InstituteInventors: Migiwa Suda, Jiro Ohkuma, Asuka Yamaguchi, Yoshitsugu Hirose, Yasuhiro Kondo, Tomohiko Kato, Daisuke Shibata
-
Publication number: 20180030432Abstract: A device for handling of magnetic particles, in which liquids and a gel-like medium are loaded. The device is provided with: a first liquid containing part in which a first liquid is contained; a second liquid contained, part in which a second liquid is contained, a third liquid containing part in which a third liquid is contained, and a first gel-like medium containing part in which the first gel-like medium is contained. The first liquid containing part, the second liquid containing part and the third liquid containing part are connected to the first gel-like medium containing part. The first liquid, the second liquid and the third liquid are separated from each other by the first gel-like medium.Type: ApplicationFiled: January 30, 2015Publication date: February 1, 2018Applicants: Shimadzu Corporation, KAZUSA DNA RESEARCH INSTITUTEInventors: Masaki KANAI, Hiroyuki JIKUYA, Tetsuo OHASHI, Shin NAKAMURA, Osamu OHARA
-
Patent number: 9850317Abstract: Problem to be Solved: The present invention is intended to provide a polynucleotide encoding the light-chain variable region and the heavy-chain variable region of an anti-dog IgE antibody; and an anti-dog IgE antibody containing these variable regions. Solution: The present invention is DNA encoding a heavy-chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 2 or 6 and DNA encoding a light-chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 4 or 8, and an anti-dog IgE monoclonal antibody which binds to dog IgE, containing these variable regions or a functional fragment thereof which binds to dog IgE.Type: GrantFiled: March 17, 2014Date of Patent: December 26, 2017Assignees: KAZUSA DNA RESEARCH INSTITUTE, ANIMAL ALLERGY CLINICAL LABORATORIES INC., NIPPON ZENYAKU KOGYO CO., LTD.Inventors: Osamu Ohara, Takahiro Nagase, Yoshihiro Yamaguchi, Reiko Ohara, Kenichi Masuda, Toshihiro Tsukui
-
Publication number: 20170326509Abstract: The present invention relates to a particle manipulation method to disperse magnetic particles 70 in a liquid 35 filling up a tube container 10, wherein a circumferential direction moving step to move the magnetic particles 70 along the circumferential direction of the container 10 in the liquid 35 and in a radial direction moving step to move the magnetic particles 70 as crossing the radial direction of the container 10 in the liquid 35 are implemented repeatedly. Such manipulations can be achieved by combining rotation of the container and gravity force and magnetic field manipulations.Type: ApplicationFiled: November 17, 2014Publication date: November 16, 2017Applicants: SHIMADZU CORPORATION, KAZUSA DNA RESEARCH INSTITUTEInventors: Jun YANAGIBAYASHI, Tetsuo OHASHI, Osamu OHARA
-
Publication number: 20160272728Abstract: Problem to be Solved: The present invention is intended to provide a polynucleotide encoding the light-chain variable region and the heavy-chain variable region of an anti-dog IgE antibody; and an anti-dog IgE antibody containing these variable regions. Solution: The present invention is DNA encoding a heavy-chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 2 or 6 and DNA encoding a light-chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 4 or 8, and an anti-dog IgE monoclonal antibody which binds to dog IgE, containing these variable regions or a functional fragment thereof which binds to dog IgE.Type: ApplicationFiled: March 17, 2014Publication date: September 22, 2016Applicants: KAZUSA DNA RESEARCH INSTITUTE, NIPPON ZENYAKU KOGYO CO., LTD., ANIMAL ALLERGY CLINICAL LABORATORIES INC.Inventors: Osamu OHARA, Takahiro NAGASE, Yoshihiro YAMAGUCHI, Reiko OHARA, Kenichi MASUDA, Toshihiro TSUKUI
-
Publication number: 20160201114Abstract: Disclosed is a particle manipulation method including steps of moving particles, which exist in a water-based liquid, into a gelled medium that is insoluble or hardly soluble in the water-based liquid in the water-based liquid, and moving the particles, which exist in the gelled medium, to the outside of the gelled medium. Preferably, the gelled medium is a gel that contains chemically crosslinking polymer. Preferably, the gelled medium has a consistency of 340 to 475. In one embodiment, the movement of the particles existing in the water-based liquid to the gelled medium and the movement of the particles existing inside the gelled medium to the water-based liquid are carried out inside a device, the device being loaded with a plurality of water-based liquids and a gelled medium interposed among the water-based liquids.Type: ApplicationFiled: July 3, 2013Publication date: July 14, 2016Applicants: SHIMADZU CORPORATION, KAZUSA DNA RESEARCH INSTITUTEInventors: Tetsuo OHASHI, Osamu Ohara, Ken Nonaka