Patents Assigned to KBP Biosciences Co., Ltd.
  • Publication number: 20190201390
    Abstract: Provided are a pharmaceutical composition comprising a mineralocorticoid receptor antagonist and use thereof. When the pharmaceutical composition is orally administered to a patient having chronic kidney disease in need thereof, the effective and safe AUC ranges from 188 ng*h/mL to 3173 ng*h/mL, with bioavailability of 50% or more in mammals. When the pharmaceutical composition is orally administered at a daily dose of 0.1 to 1.0 mg to treat chronic kidney disease, the AUC is controlled at a safe and effective level.
    Type: Application
    Filed: September 22, 2017
    Publication date: July 4, 2019
    Applicant: KBP BIOSCIENCES CO., LTD.
    Inventors: Zhenhua HUANG, Xiaocui GUO
  • Patent number: 9809589
    Abstract: The present invention belongs to the technical field of medicines, and relates to a crystal form of a compound used as a mineralocorticoid receptor antagonist and a preparation method therefor, and in particular, to a method for preparing a compound 2-chloro-4-[(3S,3aR)-3-cyclopentyl-7-(4-hydroxypiperidin-1-carbonyl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-2-yl]benzonitrile of formula (1); a crystal form thereof, a preparation method for the crystal form, and the use of the crystal form in the preparation of drugs for the treatment and/or prevention of renal injury or cardiovascular diseases.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: November 7, 2017
    Assignee: KBP BIOSCIENCES CO., LTD.
    Inventors: Chen Jiang, Aichen Wang, Dedong Zhang
  • Patent number: 9642851
    Abstract: The present invention relates to a compound represented by general formula (I), a method for preparing said compound, a pharmaceutical formulation containing said compound, and the use of said compound in manufacture of a medicament for treating or preventing the fibrous degeneration disease and treating the excessive proliferation disease: wherein ring A, X, R1, R2, R3, R4, R5, R6, R7, R8, R9, a, b and n are defined as those in the description.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: May 9, 2017
    Assignee: KBP BioSciences Co., Ltd.
    Inventors: Hoyin Lo, Aichen Wang, Qian Zhang
  • Patent number: 9468635
    Abstract: The present invention belongs to the technical field of medicine, relating in particular to: a fused ring compound as represented by Formula (I) for use as a mineralocorticoid receptor antagonist, a pharmaceutically acceptable salt thereof, and an isomer thereof; a preparation method for these compounds; a pharmaceutical preparation containing these compounds; and an application of these compounds, the pharmaceutically acceptable salt thereof, or the isomers thereof in the preparation of medicants for the treatment and/or prevention of kidney injury, cardiovascular diseases such as hypertension, and/or endocrine disease. The definitions of X, Y1, Y2, Y3, R1, R2a, R2b, R3a, R3b, R4, Cy and n are as presented in the description.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: October 18, 2016
    Assignee: KBP BIOSCIENCES CO., Ltd.
    Inventors: Zhenhua Huang, Jinyuan Wang, Dedong Zhang
  • Patent number: 9365499
    Abstract: The present invention relates to 9-aminomethyl substituted tetracycline compounds represented by formula (I), or pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, as well as a method for preparing these compounds and a pharmaceutical composition comprising the same. The present invention relates also to a use of these compounds in the preparation of a medicament for the treatment and/or prophylaxis of tetracycline drug-sensitive disease. wherein, R2a, R2b, R3, R4a, R4b, R5, R6a, R6b, R7, R8, R9a, R9b, R10, R11, R12, R13a and R13b are each independently as defined in the description.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: June 14, 2016
    Assignee: KBP Biosciences Co., Ltd.
    Inventors: Hui Zhang, Yanyan Dong
  • Patent number: 9233098
    Abstract: The present application relates to nitrogen-containing fused ring compounds shown by general formula (I), a pharmaceutically acceptable salt thereof and a stereoisomer thereof as CRTH2 antagonist, wherein X1, X2, X3, X4, X5, W, X, Y, L1, L2, L3, A, B are as defined in the description; the present application further relates to a method for preparing the compounds, a pharmaceutical formulation and a pharmaceutical composition comprising the compounds, a use of the compounds for the manufacture of a medicament for the treatment and/or prevention of diseases related to activity of CRTH2.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: January 12, 2016
    Assignee: KBP BIOSCIENCES CO., LTD.
    Inventors: Yan Zhang, Min Zhang, Hoyin Lo
  • Publication number: 20150336950
    Abstract: The present invention belongs to the technical field of medicines, and relates to a crystal form of a compound used as a mineralocorticoid receptor antagonist and a preparation method therefor, and in particular, to a method for preparing a compound 2-chloro-4-[(3S,3aR)-3-cyclopentyl-7-(4-hydroxypiperidin-1-carbonyl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-2-yl]benzonitrile of formula (1); a crystal form thereof, a preparation method for the crystal form, and the use of the crystal form in the preparation of drugs for the treatment and/or prevention of renal injury or cardiovascular diseases.
    Type: Application
    Filed: December 23, 2013
    Publication date: November 26, 2015
    Applicant: KBP BIOSCIENCES CO., LTD.
    Inventors: Chen JIANG, Aichen WANG, Dedong ZHANG
  • Publication number: 20150306095
    Abstract: The present invention relates to a compound represented by general formula (I), a method for preparing said compound, a pharmaceutical formulation containing said compound, and the use of said compound in manufacture of a medicament for treating or preventing the fibrous degeneration disease and treating the excessive proliferation disease: wherein ring A, X, R1, R2, R3, R4, R5, R6, R7, R8, R9, a, b and n are defined as those in the description.
    Type: Application
    Filed: December 6, 2013
    Publication date: October 29, 2015
    Applicant: KBP Biosciences Co., Ltd.
    Inventors: Hoyin Lo, Aichen Wang, Qian Zhang
  • Patent number: 8946279
    Abstract: The present invention belongs to the technical field of medicine, relating in particular to: a fused ring compound as represented by Formula (I) for use as a mineralocorticoid receptor antagonist, a pharmaceutically acceptable salt thereof, and an isomer thereof; a preparation method for these compounds; a pharmaceutical preparation containing these compounds; and an application of these compounds, the pharmaceutically acceptable salt thereof, or the isomers thereof in the preparation of medicants for the treatment and/or prevention of kidney injury, cardiovascular diseases such as hypertension, and/or endocrine disease. The definitions of X, Y1, Y2, Y3, R1, R2a, R2b, R3a, R3b, R4, Cy and n are as presented in the description.
    Type: Grant
    Filed: August 18, 2011
    Date of Patent: February 3, 2015
    Assignee: KBP Biosciences Co., Ltd.
    Inventors: Zhenhua Huang, Jinyuan Wang, Dedong Zhang
  • Publication number: 20140179638
    Abstract: The present invention relates to 9-aminomethyl substituted tetracycline compounds represented by formula (I), or pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, as well as a method for preparing these compounds and a pharmaceutical composition comprising the same. The present invention relates also to a use of these compounds in the preparation of a medicament for the treatment and/or prophylaxis of tetracycline drug-sensitive disease. wherein, R2a, R2b, R3, R4a, R4b, R5, R6a, R6b, R7, R8, R9a, R9b, R10, R11, R12, R13a and R13b are each independently as defined in the description.
    Type: Application
    Filed: July 26, 2012
    Publication date: June 26, 2014
    Applicant: KBP BIOSCIENCES CO., LTD.
    Inventors: Hui Zhang, Yanyan Dong
  • Patent number: 8318716
    Abstract: The present invention includes novel carbapenem derivatives having structural formula (I) or (II): wherein R1, R2, R3, R4 are described in the specification. The present invention also provides pharmaceutical compositions comprising the novel carbapenem derivatives and the use of the novel carbapenem derivatives for treating infectious diseases.
    Type: Grant
    Filed: December 31, 2009
    Date of Patent: November 27, 2012
    Assignee: KBP Biosciences Co., Ltd.
    Inventors: Zhenhua Huang, Yanyan Dong
  • Patent number: 8293895
    Abstract: The present invention relates to novel carbapenem derivatives and belongs to pharmaceutical field. Specifically, the present invention relates to the compounds as represented by formula (1), pharmaceutically acceptable salts, hydrolysable esters, isomers and intermediates thereof, wherein R1, R2, R3, R4 are described as in the description. The present invention also relates to the processes for the preparation of these compounds, to the pharmaceutical compositions comprising these compounds, and to their use for the manufacture of a medicament for the treatment and/or prevention of infectious diseases.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: October 23, 2012
    Assignee: KBP Biosciences Co., Ltd.
    Inventors: Zhenhua Huang, Yanyan Dong
  • Publication number: 20100197653
    Abstract: The present invention relates to novel carbapenem derivatives and belongs to pharmaceutical field. Specifically, the present invention relates to the compounds as represented by formulae (1) and (2), pharmaceutically acceptable salts, hydrolysable esters, isomers and intermediates thereof, wherein R1, R2, R3, R4 are described as in the description. The present invention also relates to the processes for the preparation of these compounds, to the pharmaceutical compositions comprising these compounds, and to their use for the manufacture of a medicament for the treatment and/or prevention of infectious diseases.
    Type: Application
    Filed: June 26, 2008
    Publication date: August 5, 2010
    Applicant: KBP Biosciences Co., Ltd.
    Inventors: Zhenhua Huang, Yanyan Dong