Abstract: One aspect of the present invention is directed to search receptors based on the information of HN signaling pathways in order to find Humanin receptor or Humanin-like polypeptide receptor (HNR), and to reveal a mechanism of promoting or suppressing the intracellular signal transduction for neuroprotecting activity of HN and identify a compound involved in the mechanism. The aspect of the invention is directed to a method for screening of HNR agonist and HNR antagonist, to utilize the screened compound in development of a drug for the treatment of neurodegenerative disease, and to provide an assay system of AD neuronal cell death, and to provide methods for the compulsory expression of HNR gene or knocking-out of intracellular genes.

Abstract: It is an object of the present invention to provide a multimode interference waveguide type optical switch that has a wide tolerance and that digitally performs switching with respect to a change in an applied voltage or injected current. The multimode interference waveguide type optical switch of the present invention includes an input single-mode waveguide (102) into which input light is entered, a multimode rectangular slab waveguide (103) into which light emitted from the input single-mode waveguide is entered, two electrodes (105a, 105b) that are arranged in parallel in a waveguide direction on the slab waveguide and that decrease the refractive index of the slab waveguide (103) disposed thereunder by injecting current or applying voltage, and a plurality of output single-mode waveguides (104a, 104b) into which light emitted from the slab waveguide (103) is entered and from which output light is emitted.