Abstract: Stem cells transduced with HOXB4 exhibit enhanced in vitro and in vivo ability for self-regeneration and generate higher-numbers of tranplantable pluripotent hematopoietic stem cells relative to control and nonmanipulated cells.
Type:
Grant
Filed:
November 13, 1995
Date of Patent:
November 17, 1998
Assignees:
The Regents of the University of California, Keith Humphries, Guy Sauvageau
Inventors:
Corey Largman, Hugh Jeffrey Lawrence, R. Keith Humphries, Guy Sauvageau