Abstract: The present invention relates to novel monocyclic fragments coupled to aminopiperidine naphthyridine moicty comprising antibacterial activity. These compounds can be used for treating bacterial infections, including those that nowadays are difficult and almost impossible to treat with the existing antibacterial agents.

Abstract: The present invention concerns a double passivation galvanic displacement (GD) synthesis method for production of high performance, supported noble metal-M alloy composite material, where M is an electrochemically less noble metal, compared to the noble metal, the supported noble metal-M alloy composite material obtained by the synthesis, and the use of such composite material as electrocatalyst material.

Abstract: The invention refers to the regulation of function of proteins through insertion of a peptide into the selected protein and its interaction with a regulatory peptide that interacts with the inserted peptide. The invention can be used to activate or inactivate the function of different selected proteins and therefore to regulate their properties and processes, useful for pharmacological, therapeutic, diagnostic, sensing, biotechnological and other industrial applications.

Abstract: The invention relates to a method for preparation of a polyamide 6 copolymer, characterised in that a copolymerization reaction is carried out between: o at least one caprolactam of formula (I): o at least one caprolactam, named substituted caprolactam, in which at least one of the carbon atoms is covalently linked to at least one A moiety, said A moiety being selected from the group formed of: # moieties comprising at least one group of formula: (A) #moieties comprising at least one group of formula: (B) # moieties comprising at least one group of formula: (C) The invention also relates to a polyamide 6, to polyamide 6 filaments and filaments yarns.

Abstract: The invention provides a method for enhanced genome engineering using CRISPR/Cas system tethered to exonucleases via different systems. By connecting Cas9 and exonucleases via heterodimeric peptides that form coiled-coils or via heterodimerization systems, greater indel mutations at desired genomic region occurs, resulting in higher genome editing rate. This novel improved CRISPR/Cas system can be exploited in different cell origins and organisms in various fields, where genome engineering is required and desired.

Abstract: An electrochemical cell of the lithium/sulfur type comprising: a) a cathode comprising: i) microporous carbon in the form of particles, the particle size distribution being characterized by a median volume diameter Dv50 of the particles which is greater than or equal to 1 ?m and less than or equal to 5 ?m; ii) sulfur having an oxidation degree in the range of 0 to ?2 in the pores of the microporous carbon; b) an electrolyte comprising a solvent, said solvent comprising at least one fluorinated carbonate; c) an anode composed of lithium metal or of a lithium metal alloy. The electrochemical cell exhibits an improved specific gravimetry and an improved life cycle.

Abstract: The invention provides a polypeptide chain capable of forming a polyhedron by self-assembly, nanostructure polyhedra self-assembled from single polypeptide chains and a process for preparing self-assembled polyhedra from polypeptide comprising coiled-coil-forming segments in defined combination that can form dimers that form the edges of the polypeptide polyhedra within a single polypeptide chain. A defined sequence of coiled-coil-forming segments allow self-assembly into a defined polyhedral nanostructure such as a polypeptide tetrahedron.

Abstract: Compositions having electrocatalytic activity and composites having electrocatalytic activity, as well as processes for making compositions and composites are described. Also, processes for using such compositions and/or composites, such as, for example, a machine or equipment are described. Some aspects of embodiments and/or embodiments of the present invention are directed to a nanosize transition metal alloy (such as for example an alloy and/or one or more intermetallics comprising copper, cobalt, nickel, palladium, platinum, ruthenium, the like, and combinations thereof) that is electrocatalytically active. Some other aspects of embodiments and/or embodiments of the present invention are directed to a composite material comprising a nanosize transition metal alloy and a carbonaceous matrix.

Abstract: Compositions having electrocatalytic activity and composites having electrocatalytic activity, as well as processes for making compositions and composites are described. Also, processes for using such compositions and/or composites, such as, for example, a machine or equipment are described. Some aspects of embodiments and/or embodiments of the present invention are directed to a nanosize transition metal alloy (such as for example an alloy and/or one or more intermetallics comprising copper, cobalt, nickel, palladium, platinum, ruthenium, the like, and combinations thereof) that is electrocatalytically active. Some other aspects of embodiments and/or embodiments of the present invention are directed to a composite material comprising a nanosize transition metal alloy and a carbonaceous matrix.

Abstract: The invention deals with mutated truncated mt-pfkA gene encoding shorter fragment of 6-phosphofructo-1-kinase (PFK1), with no need for phosphorylation of the protein molecule for activation, that is not significantly inhibited by citric acid and/or its salts and ATP molecules. Active 49-52 kDa fragment encoded by mt-pfkA gene, retains positive regulatory properties of the native protein and is activated in the presence of specific activators, while citric acid and ATP, important metabolites that function as feed back inhibitors in higher organisms do not reduce its activity. The invention deals with the use of modified shorter fragment in biotechnological processes for fabricating primary and secondary metabolites.