Patents Assigned to Kenji Sobue
  • Novel genes associated with the maintenance of differentiation of smooth muscle cells
    Publication number: 20050164934
    Abstract: A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
    Type: Application
    Filed: February 4, 2005
    Publication date: July 28, 2005
    Applicants: Kenji Sobue, Chugai Seiyaku Kabushiki Kaisha
    Inventors: Toshio Ota, Takao Isogai, Tetsuo Nishikawa, Koji Hayashi, Kaoru Otsuka, Jun-Ichi Yamamoto, Shizuko Ishii, Tomoyasu Sugiyama, Ai Wakamatsu, Keiichi Nagai, Tetsuji Otsuki, Shin-Ichi Funahashi, Shoji Miyata, Kenji Sobue, Kenichiro Hayashi
  • DNA encoding a protein comprising calmodulin-and actin-binding human caldesmon peptide fragment
    Patent number: 5739008
    Abstract: Provided are functional peptide fragments of human caldesmon having calmodulin and actin-binding activity, the amino acid sequences and nucleic acid sequences therefor.
    Type: Grant
    Filed: April 10, 1996
    Date of Patent: April 14, 1998
    Assignees: Kenji Sobue, Takara Shuzo Co., Ltd.
    Inventors: Ken'ichiro Hayashi, Takashi Hashida, Kiyozo Asada, Hirokazu Kotani, Ikunoshin Kato, Kenji Sobue
  • Proteins comprising calmodulin- and actin-binding human caldesmon polypeptide fragments
    Patent number: 5532337
    Abstract: Provided are functional peptide fragments of human caldesmon having calmodulin and actin-binding activity, the amino acid sequences and nucleic acid sequences therefor.
    Type: Grant
    Filed: August 4, 1994
    Date of Patent: July 2, 1996
    Assignees: Kenji Sobue, Takara Shuzo Co., Ltd.
    Inventors: Ken'ichiro Hayashi, Takashi Hashida, Kiyozo Asada, Hirokazu Kotani, Ikunoshin Kato, Kenji Sobue