Abstract: A method of assessing the brain lymphatic or glymphatic system and the glucose transporter function on blood-cerebrospinal fluid barrier (BCSFB) of a subject using D-glucose or a D-glucose analog. A spatial map is generated of water MR signals that are sensitized to changes in D-glucose or a D-glucose analog in cerebrospinal fluid (CSF) of the subject. The spatial map is observed at one or more time points before, one or more time points during, and one or more time points after, raising the blood level of the D-glucose or a D-glucose analog in the subject CSF. A difference is detected between the MR signals of the spatial map before, during, and after raising the blood level of D-glucose or a D-glucose analog. A physiological parameter associated with the brain lymphatic or glymphatic system and the glucose transporter function on BCSFB of the subject is ascertained based on the detected difference.

Abstract: The disclosure relates, in some aspects, to adeno-associated virus capsid proteins isolated from an in vivo library and recombinant adeno-associated viruses (rAAVs) comprising the same. In some aspects, the disclosure relates to isolated nucleic acids encoding AAV capsid proteins isolated from an in vivo library. In some embodiments, rAAVs and compositions described by the disclosure are useful for delivery of one or more transgenes to the muscle-tissue of a subject.

Abstract: A latch assembly for a door having a door body mounted on a door frame includes a retainer movable between a latching position and a non-latching position and configured, in the latching position, to retain the door body in a closed position, and to permit the door body to move with respect to the door frame in the non-latching position to an open position. An actuator is selectively moveable to change the retainer from the latching position to a non-latching position. A linkage is configured to move the retainer in a latching direction toward the latching position and in an unlatching direction toward the non-latching position responsive to actuation of the actuator. A crank is operatively connected to the actuator and linkage and configured to move the retainer toward the latching position as the retainer approaches the latching position.

Abstract: Some embodiments provide a method for magnetic resonance imaging of polysaccharide molecules, that includes providing a magnetic field that is sufficiently homogeneous over an imaging volume, generating a spatial encoding in the magnetic field, and acquiring one or more water proton signal intensity measurements at each of multiple voxels within the imaging volume. The signal intensity measurements are acquired at one or more irradiation frequencies at lower parts-per-million (ppm) than a baseline frequency associated with free water protons.

Abstract: A control valve body has a flow passage including an inlet, an outlet, a first portion, and a second portion, the first portion having a first axis centered through the inlet, a first bend, and a second axis, the second portion having a third axis centered through the outlet, a second bend, and a fourth axis, the fourth axis perpendicular to the second axis. The first portion is to an upstream side of a junction of the first portion and the second portion, and the second portion is to a downstream side of the junction. The second axis is centered through the junction. An opening to the second portion has a fifth axis aligned with the second axis.

Abstract: A seal includes a first elastomeric ring and a second elastomeric ring. The first elastomeric ring has an annular cavity, and the second elastomeric ring is in the annular cavity. In another embodiment, a seal includes a first elastomeric element and a second elastomeric element. The first elastomeric element has a length extending along an axis, a first surface facing radially outward with respect to the axis, and a second surface facing radially inward with respect to the axis. The second surface defines a cavity extending along the axis. The second elastomeric element is in the cavity and has a first surface facing radially outward with respect to the axis.

Abstract: A cam ring for a pipe connector includes a first axial side, a second axial side opposite the first axial side, a radially outward-facing side, a radially inward-facing side, and a cam element extending a circumferential length along the radially inward facing-side. The cam element includes a first cam section and a second can section, the cam sections respectively have first and second radially facing cam surfaces adjacent respective first and second axially facing cam surfaces. The second radially facing cam surface has a second radial depth lesser than a first radial depth of the first radially facing cam surface. The second axially facing cam surface has a second axial location closer to the first axial side than a first axial location of the first axially facing cam surface. A gripper for a pipe connector includes a body and teeth with an arc shape.

Abstract: A method of assessing the brain lymphatic or glymphatic system and the glucose transporter function on blood-cerebrospinal fluid barrier (BCSFB) of a subject using D-glucose or a D-glucose analog. A spatial map is generated of water MR signals that are sensitized to changes in D-glucose or a D-glucose analog in cerebrospinal fluid (CSF) of the subject. The spatial map is observed at one or more time points before, one or more time points during, and one or more time points after, raising the blood level of the D-glucose or a D-glucose analog in the subject CSF. A difference is detected between the MR signals of the spatial map before, during, and after raising the blood level of D-glucose or a D-glucose analog. A physiological parameter associated with the brain lymphatic or glymphatic system and the glucose transporter function on BCSFB of the subject is ascertained based on the detected difference.

Abstract: A gripper for a pipe connector includes a body, a first tooth, and a second tooth. The body has a first side, a second side adjacent the first side, a third side adjacent the first side and opposite the second side, and a fourth side adjacent the second side and the third side and opposite the first side. The first tooth extends from the fourth side of the body at a first distance from the first side of the body perpendicular to the first side of the body. The second tooth extends from the fourth side of the body at a second distance from the first side of the body perpendicular to the first side of the body. The second distance is less than the first distance.

Abstract: A butterfly valve includes a body and a gear box cover, the body having a fluid conduit and a gear platform supported on and over the fluid conduit, the gear platform configured to support a gear assembly for actuating a valve disk between an open position and a closed position, the gear box cover defining an internal cavity, the internal cavity sized to house the gear assembly, the gear box cover configured to be removably mounted to the platform such that the internal cavity is between the gear box cover and the platform.

Abstract: The disclosure relates, in some aspects, to adeno-associated virus capsid proteins isolated from an in vivo library and recombinant adeno-associated viruses (rAAVs) comprising the same. In some aspects, the disclosure relates to isolated nucleic acids encoding AAV capsid proteins isolated from an in vivo library. In some embodiments, rAAVs and compositions described by the disclosure are useful for delivery of one or more transgenes to the muscle-tissue of a subject.

Abstract: In embodiments, a gate valve includes a valve body including a flow passage from a first opening to a second opening, and a gate channel having a first end intersecting the flow passage and a second end delineated by a third opening. A valve cover fits over the third opening. A cap fits over a valve cover opening. In embodiments, a valve cover includes a body with a second sealing surface protruding from a first sealing surface, both around an opening of the body. A cap has a third sealing surface to mate with the first sealing surface, and a fourth sealing surface congruent to the second sealing surface. In embodiments, a valve cover cap includes a body with a first sealing surface on an end of a wall. Pin flanges each have a pin hole having a pin hole axis oriented perpendicular to a center axis of the wall.

Abstract: In embodiments, a gate valve includes a body including a flow passage from a first opening to a second opening, and a gate channel from the flow passage to a third opening, the gate channel having a central longitudinal axis and a ridge defining a perimeter of the opening. A valve cover can fit over the third opening and exert a clamping force on the ridge, the clamping force having a first force component perpendicular to the central longitudinal axis and a second force component parallel with the central longitudinal axis. In embodiments, a valve cover includes a first mating surface configured to extend over an opening of the gate valve, a first clamping section extending at a first non-parallel angle from a first side of the first mating surface, and a second clamping section extending at a second non-parallel angle from a second side of the first mating surface.

Abstract: A control valve body has a flow passage including an inlet, an outlet, a first portion, and a second portion, the first portion having a first axis centered through the inlet, a first bend, and a second axis, the second portion having a third axis centered through the outlet, a second bend, and a fourth axis, the fourth axis perpendicular to the second axis. The first portion is to an upstream side of a junction of the first portion and the second portion, and the second portion is to a downstream side of the junction. The second axis is centered through the junction. An opening to the second portion has a fifth axis aligned with the second axis.

Abstract: A pipe connector includes a body, a cam ring, a seal element, a push ring, and a gripper. The body has an aperture through an outer surface. The cam ring is configured to be located around the outer surface. The seal element is configured to be seated around an inner surface of the body. The push ring is configured to be slideably located within the body, and to have an aperture configured to be aligned with the aperture of the body. The gripper is configured to be located through the aperture in the body and into a first depth of the cam element. The cam ring is configured to rotate, moving the gripper axially to draw the push ring against the seal element and to move the gripper radially to grip the pipe.

Abstract: A gate for a gate valve includes a first body portion and a second body portion. The first body portion has a disc shape and a first wedging element extending from the disc shape. The second body portion has a disc shape and a second wedging element extending from the disc shape. The second body portion is pivotably connected to the first body portion. A gate valve includes a valve body and the gate. The valve body includes a first opening, a second opening, a flow passage from the first opening to the second opening, and a gate channel intersecting the flow passage. The gate is configured to move along a center axis of the gate channel between a closed position where the gate is fully in the flow passage to block fluid flow through the flow passage and an open position where fluid can flow through the flow passage.

Abstract: The disclosure relates, in some aspects, to adeno-associated vims capsid proteins isolated from an in vivo library and recombinant adeno-associated viruses (rAAVs) comprising the same. In some aspects, the disclosure relates to isolated nucleic acids encoding AAV capsid proteins isolated from an in vivo library. In some embodiments, rAAVs and compositions described by the disclosure are useful for delivery of one or more transgenes to the muscle-tissue of a subject.

Abstract: A gate valve includes a valve body including a gate channel intersecting a flow passage that extends from a first opening to a second opening. In embodiments, the gate channel has a width constant across a length extending from an intersection of the flow passage and the gate channel away from the flow passage. In embodiments, the flow passage is defined by a perimeter surface, a semi-annular slot through the perimeter surface, and a center axis through a center of the first opening and the second opening, the semi-annular slot extending on both sides of a first plane, the first plane perpendicular to a center longitudinal axis of the gate channel, the first plane parallel to and intersecting the center axis of the flow passage. In embodiments, the flow passage has an outer diameter, and a span of the gate channel containing the diameter is greater than the outer diameter.

Abstract: In one aspect, the present invention features a method of inhibiting proliferation and/or reducing survival of a cell comprising a GNAQ polynucleotide or polypeptide having a R183Q or Q209L mutation, comprising contacting the cell with puromycin or a puromycin analog, thereby inhibiting proliferation and/or reducing survival of the cell. In another aspect, a method of treating a vascular malformation or related condition in a subject, comprising administering to the subject an effective amount of puromycin or a puromycin analog is featured.

Abstract: A jack for installing a mine stopping panel includes an extendible post and a press for extending the extendible post. The press can have a lever movable between an actuated position and a non-actuated position and operative to extend the post as it moves toward the actuated position and retract the post as it moves toward the non-actuated position. A yieldable biaser yields when the post is extended to extend the mine stopping panel and the mine stopping panel engages a mine surface with sufficient force to crush a stopping seal and anchor the stopping panel. The press can comprise an over-center toggle linkage.