Patents Assigned to Kerckhoff-Klinik GmbH
  • Bioactive prostheses with immunosuppressive, antistenotic and antithrombotic properties
    Patent number: 6517858
    Abstract: The invention relates to a bioactive implant comprising a substrate coated with a polymer layer with reactive functions, and a bioactive substance fixed on the implant by means of said reactive functions to enable progressive release on the implant site. Such implants are useful in the field of cardiology for example to prevent restenosis resulting from the fitting of stents in the coronary arteries.
    Type: Grant
    Filed: May 16, 2001
    Date of Patent: February 11, 2003
    Assignees: Commissariat a L'Energie Atomique, Institut National de la Sante et de la Recherche Medicale, Kerckhoff-Klinik GmbH
    Inventors: Alain Le Moel, Natacha Betz, Christophe Bureau, Guy Deniau, Charles Baquey, Gérard Deleris, Werner Haberbosch
  • Method for the affinity-chromatographic purification of factor VIII
    Patent number: 6143179
    Abstract: The invention concerns a process for the purification of factor VIII by affinity chromatography characterized in that a biological fluid containing factor VIII is contacted with immobilized cellular von Willebrand factor or a derivative thereof under such conditions that factor VIII is adsorbed to the immobilized von Willebrand factor or derivative thereof, impurities are separated and adsorbed factor VIII is eluted.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: November 7, 2000
    Assignee: Kerckhoff-Klinik GmbH
    Inventors: Gert Muller-Berghaus, Bernd Potzsch, Horst Schwinn