Abstract: Glycerol trinitrate is delivered orally in a sustained release dosage form. The dosage form is for oral administration and comprises a core containing the drug and a coating of an expandable lattice, said expandable lattice permitting the passage of water therethrough but which under conditions of high pressure is expanded to a state whereby molecules of the drug are permitted to pass therethrough, said expandable lattice retaining its structural integrity, said dosage form when contacted with the aqueous medium of the gastro-intestinal tract taking up water in said core through passage of water through said expandable lattice, whereby an osmotic pressure is built up causing said expandable lattice to expand responsive to said osmotic pressure, the drug being permitted to escape through the resultant expanded lattice structure of said expandable lattice.

Abstract: Cardiac contractility agents are provided which are 3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methyl-n-propyl]-beta-phenethylamin e cyclodextrin complexes.

Abstract: Cardiac contractility agents are provided which are 3,4-di-isobutyryloxy-N-?3-(4-isobutyryloxyphenyl)-1-methyl-n-propyl!-beta- phenethylamine, preferably orally deliverable forms which are cyclodextrin complexes.

Abstract: There is disclosed a polymeric diffusion matrix for the sustained release of an estradiol ester by delivery to a patient requiring uterine wall maintenance or other types of estrogen therapy wherein the matrix comprises a polar plasticizer, polyvinylalcohol, polyvinylpyrrolidone, and a pharmaceutically effective amount of estradiol ester.

Abstract: A bandage is disclosed comprising a lower portion and a matrix. The lower portion has an upper surface, a base plate on the upper surface, and a post extending from the surface of the base plate. The matrix is attached to the lower portion by means of a hole extending through the matrix which fits around the post. The upper surface of the lower portion can be adhesively coated if desired. The lower portion can also be in the form of a strap. The base plate can be composed of a suitable barrier material such as metal foil or metal foil - polyester laminates. If desired, the matrix can be of a material which can dispense medicaments such as trinitroglycerol.

Abstract: There is disclosed a polymeric diffusion matrix for the sustained release of phenylephrine by transdermal delivery to a patient wherein the matrix comprises a polar plasticizer, polyvinylalcohol, polyvinylpyrrolidone, and a pharmaceutically effective amount of phenylephrine.

Abstract: There is disclosed a polymeric diffusion matrix for the sustained release of ephedrine by transdermal delivery to a patient wherein the matrix comprises a polar plasticizer, polyvinylalcohol, polyvinylpyrrolidone, and a pharamaceutically effective amount of ephedrine.

Abstract: There is disclosed a polymeric diffusion matrix for the sustained release of clonidine by transdermal delivery to a patient wherein the matrix comprises a polar plasticizer, polyvinylalcohol, polyvinylpyrrolidone, and a pharmaceutically effective amount of clonidine.

Abstract: There is disclosed a polymeric diffusion matrix for the sustained release of terbutaline by transdermal delivery to a patient wherein the matrix comprises a polar plasticizer, polyvinylalcohol, polyvinylpyrrolidone, and a pharmaceutically effective amount of terbutaline.

Abstract: There is disclosed a polymeric diffusion matrix for the sustained release of estradiol diacetate by delivery to a patient requiring uterine wall maintenance or other types of estrogen therapy wherein the matrix comprises a polar plasticizer, polyvinylalcohol, polyvinylpyrrolidone, and a pharmaceutically effective amount of estradiol diacetate.

Abstract: A polymeric diffusion matrix containing a vasodilator is provided comprising from about 2 to about 60% of a polar plasticizer, e.g., glycerol, from about 2 to about 15% of a matrix component, e.g., polyvinylalcohol, from about 2 to about 10% of a water-soluble polymer with hydration sites, e.g., polyvinylpyrrolidone, which in combination with the remaining ingredients yields a matrix capable of sustained release of a vasodilator drug dispersed therein, and the balance water, the percentages being by weight.

Abstract: There is disclosed a polymeric diffusion matrix for the sustained release of phenylpropanolamine by transdermal delivery to a patient wherein the matrix comprises a polar plasticizer, polyvinylalcohol, polyvinylpyrrolidone, and a pharmaceutically effective amount of phenylpropanolamine.

Abstract: A disposable rectal insert of plastic material chemically inert to body fluids encapsulating a freezable medium having a freezing point of about 0.degree. to 32.degree.F. The insert has a small bulbous end for rectal insertion which is collapsible upon melting of the medium and compensating dilation of the other enlarged reservoir end maintains constant internal volume of the insert.