Patents Assigned to Keystone Biomedical, Inc.
  • Chemical synthesis of exochelins
    Patent number: 6335443
    Abstract: A process for the synthetic generation of high affinity, iron binding compounds known as Exochelins, and more particularly, to a synthetic process for making Exochelins and to modifications to these newly synthesized compounds to vary their physiological properties, including applications of these newly synthesized and utile compounds for diagnosing and treating disease in mammals.
    Type: Grant
    Filed: March 5, 1999
    Date of Patent: January 1, 2002
    Assignee: Keystone Biomedical, Inc.
    Inventors: Leo S. Geraci, Stuart G. Levy, James P. Hudspeth, Richard L. Buswell, Jay F. Stearns
  • Process for the synthesis of exochelins
    Patent number: 6063919
    Abstract: A process for the synthesis of an Exochelin comprising the steps of generating L-N-[(2-benzyloxy-(benzoyl)] serine or L-N-[2-benzyloxy (benzoyl)] threonine, creating L-N-t-Boc-.epsilon.-hydroxynorleucine and reacting same to produce L-N-Boc-.epsilon.-bromonorleucine trimethylsilylethyl ester, providing a dicarboxylic acid and forming an O-benzyl methyl hydroxamate from the dicarboxylic acid, coupling the O-benzyl methyl hydroxamate with the L-N-Boc-.epsilon.-bromonorleucine trimethylsilylethyl ester to give an L-N.sup.2 -Boc-N.sup.6 -methyl,N.sup.6 -(benzyloxy) lysine 2-trimethylsilylethyl ester which incorporates the dicarboxylic acid as modified above, removing the N-tert-butoxycarbonyl protecting group from the L-N.sup.2 -Boc-N.sup.6 -methyl, N.sup.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: May 16, 2000
    Assignee: Keystone BioMedical, Inc.
    Inventors: Larry A. Gaudioso, Michael A. Weglarz
  • Chemical synthesis of exochelins
    Patent number: 5952492
    Abstract: A process for the synthetic generation of high affinity, iron binding compounds known as Exochelins, and more particularly, to a synthetic process for making Exochelins and to modifications to these newly synthesized compounds to vary their physiological properties, including applications of these newly synthesized and utile compounds for diagnosing and treating disease in mammals.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: September 14, 1999
    Assignee: Keystone Biomedical, Inc.
    Inventors: Leo S. Geraci, Stuart G. Levy, James P. Hudspeth, Richard L. Buswell, Jay F. Stearns
  • Method for the treatment of cancer with Exochelins of Mycobacterium tuberculosis
    Patent number: 5837677
    Abstract: The invention is directed toward the use of desferri-Exochelins to destroy cancer cells or retard or eliminate the growth of those cancer cells.
    Type: Grant
    Filed: June 25, 1997
    Date of Patent: November 17, 1998
    Assignee: Keystone Biomedical, Inc.
    Inventors: Lawrence D. Horwitz, Kathryn B. Horwitz