Abstract: In general, the invention features an intra-vascular device for filtering or deflecting emboli or other large objects from entering a protected secondary vessel or vessels. the device of the invention may include a filter to prevent a particle in a blood vessel from passing through the filter, a lateral structure to hold the filter, and two wires attached to lateral structure, on each at its distal and proximal ends. These wires may be used to control the deflection or orientation of the filter upon its installation within a blood vessel. Further, in some embodiments, these wires may be capable of readily detaching from the device, thus making it possible to install a filter without any significant appendages in a blood vessel.

Abstract: A system for transvascular delivery to an aortic arch of a patient includes an embolic protection device, a connector mechanism, and a catheter or sheath for delivering the embolic protection device to a working zone. The embolic protection device includes a support frame having a distal portion and a proximal portion, and a filter member attached to the support frame and configured for preventing embolic materials from passing there through. At least one of the distal portion and the proximal portion includes a spring section configured for providing a radial force between the support frame and a wall of the aortic arch when in an expanded state. The embolic protection device is pivotable axially but not radially relative to the connector mechanism.

Abstract: An introducer sheath assembly having a handle portion including a distal end and a proximal end, and an introducer sheath extending outwardly from the distal end of the handle portion, the introducer sheath including a device lumen configured to slidably receive a corresponding device, a guidewire lumen configured to slidably receive a corresponding guidewire, and at least one steering cable disposed within at least one steering cable lumens that are disposed radially outwardly from the device lumen, and the handle portion including at least one steering assembly for modifying the tension of at least one of the at least one steering cables.

Abstract: In general, the invention features an intra-vascular device for filtering or deflecting emboli or other large objects from entering a protected secondary vessel or vessels. the device of the invention may include a filter to prevent a particle in a blood vessel from passing through the filter, a lateral structure to hold the filter, and two wires attached to lateral structure, on each at its distal and proximal ends. These wires may be used to control the deflection or orientation of the filter upon its installation within a blood vessel. Further, in some embodiments, these wires may be capable of readily detaching from the device, thus making it possible to install a filter without any significant appendages in a blood vessel.

Abstract: An intra-aortic device comprising a filter and a frame defining the shape of the filter, wherein the frame is intrinsically curved in a superior direction by a proximal superior bend and/or a distal superior bend, whereupon installation in an aorta, the M frame flattens.

Abstract: An intra-aortic device comprising a filter and a frame defining the shape of the filter, wherein the frame is intrinsically curved in a superior direction by a proximal superior bend and/or a distal superior bend, whereupon installation in an aorta, the M frame flattens.

Abstract: A method of manufacturing an emboli filter membrane having a three-dimensional (3D) structure from a sheet of fabric made from at least of strand and a device comprising such filter membrane. The filter membrane is manufactured using a mold made from two parts, a first part having a cavity in the shape of the three-dimensional structure surrounded by a first surface, a second part having a protrusion in the shape of the three-dimensional structure surrounded by a second surface. When the mold is closed there is a space between a surface of the cavity and a surface of the protruding portion.

Abstract: An embolic protection device for transvascular delivery to an aortic arch of a patient for protection of side branch vessels of said aortic arch from embolic material. The device comprises a support frame, wherein at least a distal or a proximal portion of the support frame is a spring section configured for providing a radial force between the support frame and a wall of the aortic arch when in an expanded state.

Abstract: An embolic protection device for transvascular delivery to an aortic arch of a patient for protection of side branch vessels of said aortic arch from embolic material. The device comprises a support frame, wherein at least a distal or a proximal portion of the support frame is a spring section configured for providing a radial force between the support frame and a wall of the aortic arch when in an expanded state.

Abstract: A method of manufacturing an emboli filter membrane having a three-dimensional (3D) structure from a sheet of fabric made from at least of strand and a device comprising such filter membrane. The filter membrane is manufactured using a mold made from two parts, a first part having a cavity in the shape of the three-dimensional structure surrounded by a first surface, a second part having a protrusion in the shape of the three-dimensional structure surrounded by a second surface. When the mold is closed there is a space between a surface of the cavity and a surface of the protruding portion.

Abstract: In general, the invention features an intravascular device, a delivery system, and methods for filtering or deflecting emboli or other large objects from entering a protected secondary vessel or vessels The intravascular device of the invention may prevent passage of a particle in a blood vessel from passing through a filter supported by a frame, upper and lower stabilizers, and a wire. The wire may be used to stabilize the device upon its deployment and installation within a blood vessel. Further, in some embodiments, the invention features a delivery system and methods for introduction of the device into a blood vessel.

Abstract: A method for filtering particulate matter from a blood vessel in a patient, including inserting a device into the blood vessel, the device including at least an outer structure capable of insertion into the blood vessel; and an inner filter anchored to the outer structure, the inner filter having a one-way valve though which a medical instrument may be passed.

Abstract: This invention relates to devices that are inserted in a blood vessel or other body lumen, and in particular to filter that may block particles from entering a blood vessel. Devices of this invention position and secure a filter in a vascular system to intercept particulates, including emboli.

Abstract: In general, the invention features an intra-vascular device for filtering or deflecting emboli or other large objects from entering a protected secondary vessel or vessels. The device of the invention may include a filter, an central member, additional supporting members, and a delivery cable and may serve to filter or deflect emboli or other large objects from entering protected secondary vessels. The device may be capable of collapse along its longitudinal axis for ease of delivery to the treatment site. The device may further be compatible with common delivery methods used in interventional cardiology (e.g., TAVI procedures). The device may be integrated into the delivery systems. In other embodiments the device may be detachable from the delivery system. Upon deployment, the device may be positioned so as to contact the orifice of one or more secondary blood vessels. Upon retrieval the device may be retracted in an orientation substantially similar to the original deployment orientation.

Abstract: This invention relates to devices that are inserted in a blood vessel or other body lumen, and in particular to filter that may block particles from entering a blood vessel. Devices of this invention position and secure a filter in a vascular system to intercept particulates, including emboli.

Abstract: An intra-aortic device comprising a filter and a frame defining the shape of the filter, wherein the frame is intrinsically curved in a superior direction by a proximal superior bend and/or a distal superior bend, whereupon installation in an aorta, the frame flattens.

Abstract: An embolic protection device for transvascular delivery to an aortic arch of a patient for protection of side branch vessels of said aortic arch from embolic material. The device comprises a support frame, wherein at least a distal or a proximal portion of the support frame is a spring section configured for providing a radial force between the support frame and a wall of the aortic arch when in an expanded state.

Abstract: In general, the invention features an intravascular device, a delivery system, and methods for filtering or deflecting emboli or other large objects from entering a protected secondary vessel or vessels The intravascular device of the invention may prevent passage of a particle in a blood vessel from passing through a filter supported by a frame, upper and lower stabilizers, and a wire. The wire may be used to stabilize the device upon its deployment and installation within a blood vessel. Further, in some embodiments, the invention features a delivery system and methods for introduction of the device into a blood vessel.