Patents Assigned to KEZAR LIFE SCIENCES
  • Process of preparing a peptide epoxyketone immunoproteasome inhibitor, and precursors thereof
    Patent number: 11976053
    Abstract: Disclosed herein are methods for preparing [(2S,3R)—N—[(2S)-3-(cyclopent-1-en-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide (compound “G”): and precursors thereof.
    Type: Grant
    Filed: October 13, 2022
    Date of Patent: May 7, 2024
    Assignee: KEZAR LIFE SCIENCES, INC.
    Inventors: Henry Johnson, Sean Dalziel, Dustin McMinn
  • Crystalline salts of peptide epoxyketone immunoproteasome inhibitor
    Patent number: 11891383
    Abstract: Provided herein is a peptide epoxyketone immunoproteasome inhibitor, crystal forms, salts, and processes for making the same, and formulations thereof.
    Type: Grant
    Filed: September 27, 2022
    Date of Patent: February 6, 2024
    Assignee: KEZAR LIFE SCIENCES
    Inventors: Henry Johnson, Evan Lewis, Sean Dalziel, Dustin McMinn
  • Triazacyclododecansulfonamide (“TCD”)-based protein secretion inhibitors
    Patent number: 11578055
    Abstract: Provided herein are triazacyclododecansulfonamide (“TCD”)-based protein secretion inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions, and methods for using the same. For example, provided herein are compounds of Formula (I) and pharmaceutically acceptable salts and compositions including the same. The compounds disclosed herein may be used, for example, in the treatment of diseases including inflammation and/or cancer.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: February 14, 2023
    Assignee: KEZAR LIFE SCIENCES
    Inventor: Henry Johnson
  • Process of preparing a peptide epoxyketone immunoproteasome inhibitor, and precursors thereof
    Patent number: 11498907
    Abstract: Disclosed herein are methods for preparing [(2S,3R)-N-[(2S)-3-(cyclopent-1-en-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide (compound “G”): and precursors thereof.
    Type: Grant
    Filed: September 9, 2020
    Date of Patent: November 15, 2022
    Assignee: KEZAR LIFE SCIENCES
    Inventors: Henry Johnson, Sean Dalziel, Dustin McMinn
  • Crystalline salts of peptide epoxyketone immunoproteasome inhibitor
    Patent number: 11479548
    Abstract: Provided herein is a peptide epoxyketone immunoproteasome inhibitor, crystal forms, salts, and processes for making the same, and formulations thereof.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: October 25, 2022
    Assignee: KEZAR LIFE SCIENCES
    Inventors: Henry Johnson, Evan Lewis, Sean Dalziel, Dustin McMinn
  • CDP protein secretion inhibitors
    Patent number: 11339193
    Abstract: Provided herein are compounds that inhibit protein secretion, e.g., via inhibition of Sec61. Also provided are compositions of the inhibitor compounds, and methods of using these inhibitors. The compounds disclosed herein can be used, e.g., for the treatment of cancer, arthritis, and/or inflammation.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: May 24, 2022
    Assignees: KEZAR LIFE SCIENCES, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Dustin McMinn, John William Taunton, Phillip Patrick Sharp
  • Crystalline salts of peptide epoxyketone immunoproteasome inhibitor
    Patent number: 10836756
    Abstract: Provided herein is a peptide epoxyketone immunoproteasome inhibitor having a structure: Formula (I) wherein X— is a counterion, crystal forms, salts, and processes for making the same, and formulations thereof.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: November 17, 2020
    Assignee: KEZAR LIFE SCIENCES
    Inventors: Henry Johnson, Evan Lewis, Sean Dalziel, Dustin McMinn
  • Process of preparing a peptide epoxyketone immunoproteasome inhibitor, and precursors thereof
    Patent number: 10781192
    Abstract: Disclosed herein are methods for preparing [(2S,3R)—N-[(2S)-3-(cyclopent-1-en-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide (compound “G”): and precursors thereof.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: September 22, 2020
    Assignee: KEZAR LIFE SCIENCES
    Inventors: Henry Johnson, Sean Dalziel, Dustin McMinn
  • CRYSTALLINE SALTS OF PEPTIDE EPOXYKETONE IMMUNOPROTEASOME INHIBITOR
    Publication number: 20190308961
    Abstract: Provided herein is a peptide epoxyketone immunoproteasome inhibitor having a structure: Formula (I) wherein X— is a counterion, crystal forms, salts, and processes for making the same, and formulations thereof.
    Type: Application
    Filed: June 29, 2017
    Publication date: October 10, 2019
    Applicant: KEZAR LIFE SCIENCES
    Inventors: Henry Johnson, Evan Lewis, Sean Dalziel, Dustin McMinn
  • PROCESS OF PREPARING A PEPTIDE EPOXYKETONE IMMUNOPROTEASOME INHIBITOR, AND PRECURSORS THEREOF
    Publication number: 20190194155
    Abstract: Disclosed herein are methods for preparing [(2S,3R)—N-[(2S)-3-(cyclopent-1-en-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide (compound “G”): and precursors thereof.
    Type: Application
    Filed: June 29, 2017
    Publication date: June 27, 2019
    Applicant: KEZAR LIFE SCIENCES
    Inventors: Henry Johnson, Sean Dalziel, Dustin McMinn