Patents Assigned to Khloris Biosciences, Inc.
  • IPSC-BASED VACCINE AS A PROPHYLACTIC AND THERAPEUTIC TREATMENT FOR CANCER
    Publication number: 20230181708
    Abstract: In one embodiment, the application discloses a method for the treatment of cancer in a patient, the method comprises a vaccination of the patient with a vaccine, wherein the vaccine comprises an effective amount of mammalian pluripotent stem cells obtained from an embryonic source or obtained by reprogramming of somatic cells from the patient, wherein the vaccination comprising the step of administering a mammalian pluripotent stem cells to the patient in need thereof; and vaccine formulations for use in the treatment of cancer.
    Type: Application
    Filed: August 13, 2022
    Publication date: June 15, 2023
    Applicant: Khloris Biosciences, Inc.
    Inventors: Nigel G. Kooreman, Stephen D. Wolpe, Lynne A. Bui
  • INDUCED PLURIPOTENT STEM CELL-BASED CANCER VACCINES
    Publication number: 20220387569
    Abstract: In one embodiment, the present application discloses a mammalian autologous vaccine or allogeneic vaccine comprising an effective amount of a mammalian induced pluripotent stem cells (iPSCs) obtained by reprogramming of somatic cells from a patient; wherein the autologous vaccine or the allogeneic vaccine expresses a gene selected from the group consisting of ASTE1, BIRC5, CDCA1, CDKN2A, DEPDC1, EGFR, ERBB2, FOXM1, GPC3, HJURP, HSPA8, HSP90B1, IDH1, IDO1, IGF2BP3, IMPS, KIF20A, KIF20B, MELK, MGAT5, NUF2, PMEL, RAS, TAF1B, TOMM34, TTK, TP53, VEGFR1 and VEGFR2; and wherein the autologous vaccine or the allogeneic vaccine induces an immune response from the patient for the treatment of cancer.
    Type: Application
    Filed: May 30, 2022
    Publication date: December 8, 2022
    Applicant: Khloris Biosciences, Inc.
    Inventors: Stephen D. Wolpe, Lynne A. Bui, Nigel G. Kooreman
  • IPSC-based vaccine as a prophylactic and therapeutic treatment for cancer
    Patent number: 11298380
    Abstract: In one embodiment, the application discloses a method for the treatment of cancer in a patient, the method comprises a vaccination of the patient with a vaccine, wherein the vaccine comprises an effective amount of mammalian pluripotent stem cells obtained from an embryonic source or obtained by reprogramming of somatic cells from the patient, wherein the vaccination comprising the step of administering a mammalian pluripotent stem cells to the patient in need thereof; and vaccine formulations for use in the treatment of cancer.
    Type: Grant
    Filed: January 1, 2019
    Date of Patent: April 12, 2022
    Assignees: Khloris Biosciences, Inc., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Nigel G. Kooreman, Joseph C. Wu, Lynne A. Bui
  • IPSC-BASED VACCINE AS A PROPHYLACTIC AND THERAPEUTIC TREATMENT FOR CANCER
    Publication number: 20190290697
    Abstract: In one embodiment, the application discloses a method for the treatment of cancer in a patient, the method comprises a vaccination of the patient with a vaccine, wherein the vaccine comprises an effective amount of mammalian pluripotent stem cells obtained from an embryonic source or obtained by reprogramming of somatic cells from the patient, wherein the vaccination comprising the step of administering a mammalian pluripotent stem cells to the patient in need thereof; and vaccine formulations for use in the treatment of cancer.
    Type: Application
    Filed: January 1, 2019
    Publication date: September 26, 2019
    Applicants: Khloris Biosciences, Inc., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nigel G. Kooreman, Joseph C. Wu, Lynne A. Bui