Abstract: The present invention is intended to provide a medicament for cyanide poisoning, hydrogen sulfide poisoning, and azide poisoning, wherein the medicament does not cause side effects, is excellent in immediate effectiveness, and has a high antidotal effect. Specifically, the present invention relates to a medicament for cyanide poisoning, hydrogen sulfide poisoning, and azide poisoning, wherein the medicament comprises, as an active ingredient(s), one or more selected from the group consisting of a heme protein capable of binding to cyanide ions (CN?), hydrogen sulfide ions (HS?) and azide ions (N3?), a substance containing a heme protein capable of binding to CN?, HS? and N3?, and a heme derivative capable of binding to CN?, HS? and N3?. More specifically, the present invention relates to a medicament or a pharmaceutical composition for the treatment or prophylaxis of cyanide poisoning, hydrogen sulfide poisoning, and azide poisoning.
Type:
Application
Filed:
August 27, 2021
Publication date:
October 5, 2023
Applicants:
KEIO UNIVERSITY, PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY, KIMIGAFUCHI GAKUEN
Abstract: A vibration damping device for suppressing vibrations of a structure includes: a slide body mechanism having a concave slide body and a convex slide body which are fixed to the structure and are arranged so as to be slidable relative to each other in a reciprocating manner; and a biasing means which pushes the slide bodies to each other. Each slide body has: a first slide surface having a shape which increases a height of the slide body mechanism 2 along with the increase of a displacement amount of the slide body in one sliding direction from a neutral position relative to the counterpart slide body; and a second slide surface having a shape by which the height of the slide body mechanism is increased along with the increase of the displacement of the slide body in the other sliding direction from the neutral position.
Type:
Grant
Filed:
June 14, 2011
Date of Patent:
June 9, 2015
Assignees:
National University Corporation Kumamoto University, Kimigafuchi Gakuen
Inventors:
Toshitaka Yamao, Takuro Katayama, Koji Azuma
Abstract: A vibration damping device for suppressing vibrations of a structure includes: a slide body mechanism having a concave slide body and a convex slide body which are fixed to the structure and are arranged so as to be slidable relative to each other in a reciprocating manner; and a biasing means which pushes the slide bodies to each other. Each slide body has: a first slide surface having a shape which increases a height of the slide body mechanism 2 along with the increase of a displacement amount of the slide body in one sliding direction from a neutral position relative to the counterpart slide body; and a second slide surface having a shape by which the height of the slide body mechanism is increased along with the increase of the displacement of the slide body in the other sliding direction from the neutral position.
Type:
Application
Filed:
June 14, 2011
Publication date:
May 2, 2013
Applicants:
National University Corporation Kumamoto University, Kimigafuchi Gakuen
Inventors:
Toshitaka Yamao, Takuro Katayama, Koji Azuma
Abstract: The present invention provides an apoptosis inducer comprising, as active ingredients, a compound selected from the group consisting of di(alkylcarbonyl) phosphatidylcholine, di(alkylcarbonyl) phosphatidylalkanolamine, di(alkylcarbonyl) phosphatidylinositol and di(alkylcarbonyl) phosphatidylserine.