Abstract: An inhaler comprising an elongate housing containing a reservoir of inhalable composition. An outlet for the composition and suction port are provided at one end of the housing. A diaphragm is mounted in the housing defining a suction chamber such that suction on the suction port reduces the size of the suction chamber. An elongate leaf spring is mounted at one end to the housing at the end of the suction chamber opposite to the suction port, and is pivotally mounted at an intermediate portion about a pivot point. A valve element is at the end of the leaf spring opposite to the one end and is biased closed. Suction on the suction port deflects the diaphragm and hence the leaf spring between the one end and the pivot point causing the opposite end of the leaf spring to pivot about the pivot point thereby causing the valve element to open.

Abstract: An inhaler comprising a reservoir of an inhalable composition. A valve element moved by a flexible diaphragm and biased into a position in which it closes a composition flow path from a reservoir. A first air flow path is partly defined by one side of the diaphragm and a second air flow path is partly defined by the opposite side of the diaphragm. Each flow path has an outlet opening at an outlet end and the second flow path has an inlet upstream of the outlet end. The air flow paths are arranged such that suction at the outlet end causes a reduction in pressure in the first air flow path relative to the pressure in the second air flow path creating a pressure differential across the diaphragm that moves the valve element against the biasing force to open the composition flow path.

Abstract: An inhalable composition for use as a medicament in the treatment of a subject wherein said composition comprises: one or more cannabinoids or a pharmaceutically acceptable derivative or salt thereof; a propellant; a monohydric or polyhydric alcohol; and a glycol and/or glycol ether, characterised in that the ratio of monohydric or polyhydric alcohol to glycol or glycol ether by weight is from 6:1 to 1:1, wherein the composition is administered in the form of an aerosol having a fine particle fraction of 60% or more.

Abstract: A simulated cigarette having a generally cylindrical cigarette like housing with a main axis, the housing containing a reservoir of a pressurised inhalable composition. The reservoir has a reservoir outlet at one end which is selectively closed by an outlet valve. The simulated cigarette further comprises a tube with a through bore extending along a substantial portion of the reservoir from the vicinity of the reservoir outlet such that composition flows into a tube bore inlet and along the tube bore to the reservoir outlet. The tube inlet end is retained such that the axis passes through the inlet end and so that the tube bore inlet is positioned in the axial sense in the central 50% of the volume of the reservoir.

Abstract: An inhaler comprising a reservoir of an inhalable composition with an outlet at one end through which the inhalable composition is discharged. A non-metered breath-activated valve is provided between the one end and the reservoir, the breath-activated valve comprising a flow path extending from the reservoir to the outlet end. At least a portion of the flow path is a deformable tube. A clamping member pinches the deformable tube closed when no suction force is applied to the device and releases the tube to open the flow path when suction is applied at the outlet, to provide uninterrupted flow from the reservoir to the outlet.

Abstract: A combination of an inhaler and a refill pack. The inhaler comprises a reservoir for an inhalable composition, a heating element and/or vibrating transducer to selectively volatilise at least some components of the composition and at least one inhaler capacitor arranged to supply electrical power to the heater and/or vibrating transducer when a user inhales from the inhaler. The refill pack comprises a refill reservoir of inhalable composition and a battery coupled to a refill capacitor, and is arranged to engage with the inhaler and to simultaneously refill the reservoir and recharge the inhaler capacitor from the refill capacitor. The invention also extends to the inhaler and refill pack separately and to a method of refilling and recharging the inhaler.

Abstract: An inhaler according to an embodiment has a breath operated valve with a valve element biased closed by a spring and a diaphragm arranged to deform when suction is applied to an outlet end generating low pressure above the diaphragm to lift the valve element against the biasing force of the spring allowing composition to flow out of the inhaler. The spring is a strip of resilient material forming a u-shape with a first arm extending from a position adjacent to the valve element along the diaphragm in a direction away from the outlet end so as to support the diaphragm to an apex where it extends away from the diaphragm into a second arm extending back towards the outlet end, the second arm engaging with the housing to generate a biasing force to urge the valve element closed.

Abstract: An inhaler comprising a reservoir of an inhalable composition. A housing contains the reservoir and has an outlet end and an opposite end. A composition flow path for the flow of the composition extends from the reservoir along the flow path and out of a composition outlet at the outlet end of the housing. A flexible diaphragm within the housing defines an air flow path from an air inlet to an air outlet at the outlet end of the housing, the diaphragm extending past the air flow inlet towards the opposite end separating the air flow path on one side of the diaphragm from the remainder of the housing on the opposite side of the diaphragm.

Abstract: An inhaler comprising a source of inhalable composition. An outlet flow path is provided for the composition from the source to a composition outlet at an outlet end of the inhaler. Means are provided to generate a flow of composition from the source along the outlet flow path and out of the composition outlet when suction is applied to the outlet end. A pair of air outlets at the outlet end are arranged on opposite sides of the composition outlet through which air is drawn in respective air jets when suction is applied to the outlet end. The composition and air outlets are arranged such that, in use, the pair of air jets impinge on the composition plume.

Abstract: An inhalable composition for use as a medicament in the treatment of a subject wherein said composition comprises: one or more cannabinoids or a pharmaceutically acceptable derivative or salt thereof; a propellant; a monohydric or polyhydric alcohol; and a glycol and/or glycol ether, characterized in that the ratio of monohydric or polyhydric alcohol to glycol or glycol ether by weight is from 6:1 to 1:1, wherein the composition is administered in the form of an aerosol having a fine particle fraction of 60% or more.

Abstract: A simulated smoking device (1) comprising a simulated cigarette having a substantially cylindrical cigarette-like shape and a refill device (2, 50) having a substantially cuboid housing with a cigarette pack-like shape containing refill gas (32, 59) for the simulated cigarette and having means for selectively retaining the simulated cigarette. The simulated cigarette may be retained wholly within the housing. It may be retained at a location different from the refill location. A dose counter may be provided to give a visual indication of the doses in the refill device.

Abstract: A pressurised container containing a liquid composition to be dispensed and a propellant to pressurise the container. The container has a non-metred outlet valve at its lower end such that it is in communication with liquid in the container when the container is oriented with the valve lowermost. The valve comprises a valve stem having an outlet towards the bottom end communicating with an inlet as a lateral port through the side of the stem, the lateral port being positioned such that it is moveable between a first position out of communication with the liquid and a second position in communication with the liquids. A resilient element biases the valve element to the first position. A sealing plate which surrounds the valve stem and has a first seal and a second seal. An end cap is fitted over the sealing plate.

Abstract: The present invention relates to a cascade impactor for measuring particle size distribution of an aerosol comprising nicotine, the cascade impactor comprising: an induction port for receiving an inhaler; and at least one sample collection stage comprising a nozzle assembly and a collection means; wherein the collection means of at least one sample collection stage is coated with isopropyl alcohol.

Abstract: A pressurized refill canister containing a reservoir of composition including a propellant and a nicotine or a pharmaceutically acceptable derivative or salt thereof. The reservoir is at a pressure of greater than 400 kPa at 20° C. A refill outlet valve comprises a stem with an axial bore open at the axial end furthest from the reservoir to provide an outlet which discharges the composition in an axial direction. The stem is displaceable from a closed position to which it is biased by a first resilient member with a spring force of greater than 10N when no external force is applied to a dispensing position against the action of the first resilient member to open a flow path from the reservoir to the outlet.

Abstract: An inhaler comprising a reservoir of an inhalable composition, a heater to selectably volatilize at least some components of the composition, and a power source arranged to selectively supply electrical power to the heater when the user inhales from the inhaler. The power source is arranged to heat the heater to a temperature that will volatilize some, but not all of the components of the composition.

Abstract: A pressurized refill canister containing a composition including a propellant. The canister has an outlet valve having a stem biased to a closed position by a first resilient member. The stem has a maximum outer diameter of greater than 3 mm. At the outlet end of the stem, at least part of the wall of the stem extends inwardly from the outside diameter for at least 50% of the radius.

Abstract: The present invention provides a cannabinoid inhaler, compositions, and methods for delivering a cannabinoid composition to a subject. The cannabinoid composition is delivered in the form of inhaled droplets of respirable size via pulmonary administration. The invention may be used in the treatment of a condition or disorder selected from the group consisting of neuropathic pain, cannabis addiction, nausea, motion sickness, arthritis, and neurodegenerative disease.

Abstract: A pressurized refill canister containing a reservoir of composition including a propellant, and a non-metered refill outlet valve comprising a stem displaceable from a first position to a dispensing position against the action of a resilient member. The stem comprises a blind bore open at an outlet end and closed at the opposite end and a lateral bore in the side wall of the stem leading to the blind bore. The refill outlet valve further comprises an annular seal which surrounds the stem whereby, in the first position, the lateral bore is not in communication with the inside of the canister, and in the dispensing position, the lateral bore is arranged to move inside the canister with respect to the seal to open a flow path from the inside of the canister via the lateral bore and along the blind bore to the outlet end.

Abstract: A method of assembling a tubular simulated cigarette, the method comprising providing an elongate hollow housing having an inhaling end and a refill end; inserting an outlet valve tube, a dip tube and a support from the refill end so that the support supports the proximal end of the dip tube in the housing; inserting a refill valve into the refill end and fixing it in place to form a composition reservoir with the dip tube placing the reservoir in fluid communication with an outlet orifice when the outlet valve tube is open; inserting a valve element into a recess in the side of the housing so that the valve element is positioned to selectively close the outlet valve tube; inserting a breath operated valve actuation mechanism laterally into the recess; and applying a cover to the recess.

Abstract: A simulated cigarette which has a reservoir of an inhalable composition and an outlet valve to control the outlet flow. The outlet end is provided with a deformable material to provide a more realistic feel and optionally to allow the user to vary the flow characteristics in the manner of a real cigarette. The outlet end can also be provided with a chemical heater. The simulated cigarette is wrapped in a paper or paper-like wrap to provide a more realistic feel.