Abstract: Disclosed is a centrifuging device with a detachable cover and a safeguard structure in which the cover of the centrifuging device can be completely separated from the housing; and the safeguard structure can prevent a rotor from becoming separated from a drive shaft during operation due to flange defection and prevent the fractured pieces of the rotor from springing out of the housing when the rotor breaks or cracks. The centrifuging device according to the invention offers ease of cleaning and improved safety. Furthermore, there is no need to worry about the fracture of a coupling portion between the cover and the housing attributable to the repeated opening and closing.