Abstract: In one aspect, the invention provides cell cultures and culture conditions that facilitate the establishment of an intestinal epithelial cell culture that has characteristics of the intestinal epithelium, such as: transepithelial electrical resistance, enzyme expression and microvilli morphology. Cell cultures of the invention may use fatty acids such as sodium butyrate and kinase modulators such as 2-{1-[3-(amidinothio)propyl]-1H-indol-3-yl}-3-(1-meethylindol-3-yl)-maleimide methanesulfonate.
Type:
Application
Filed:
August 25, 2003
Publication date:
June 17, 2004
Applicant:
KINETANA GROUP INC.
Inventors:
Yi-Chan James Lin, Yun Kau Tam, Hugh Alexander Semple, Brian Duff Sloley