Abstract: The invention is directed to a method for diagnosing and treating fibrosis, especially pulmonary fibrosis, associated with mutation of the S100A13 and S100A3 genes. Methods for detecting and distinguishing the mutant forms of these genes are disclosed and ways to compensate for loss of function or aberrant function of the mutated S100A13 or S100A3 proteins are disclosed.

Abstract: The invention relates to methods for generating multipotent mammary stern cells from isolated and cultured human breast luminal cells. The method comprises the steps: 1. isolating and growing normal differentiated cells in vitro; 2. treating the differentiated cells with either a conditioned medium from active fibroblasts or cytokine. The invention also relates to multipotent mammary stem cells, cultures of the multipotent stem cells, differentiated cells, tissues, organs derived from the culture multipotent stem cells isolated by the methods disclosed and therapeutic and other uses for those cells thereof.

Abstract: The present invention further relates to using vaccinia virus complement control protein (VCP), factor H and/or a complement control protein (CCP)-containing protein as modulator of the entry and/or replication of pathogen(s), wherein the pathogen is a virus or bacteria. The present invention further relates to a method of prevention and/or treatment of influenza A virus (IAV) infection in a subject of need thereof and to a method of modulation of the entry and/or replication of pathogen(s) in a subject of need thereof.

Abstract: The present invention relates to a set of genes for use in a method of predicting the likelihood of a breast cancer patient's survival or of predicting the likelihood of a recurrence and/or aggressiveness of a breast cancer in a breast cancer patient. The present invention also relates to a method for predicting the likelihood of a breast cancer patient's survival or the likelihood of the recurrence or aggressiveness of a breast cancer in a breast cancer patient, as well as to a kit for use in such method.

Abstract: The present invention relates to a method of determining if a patient is likely to respond to a treatment with a targeted therapy compound selected from protein kinase inhibitors, small molecule inhibitors, and monoclonal antibody-based compounds. The present invention further relates to a method of identifying a targeted therapy compound selected from protein kinase inhibitors, small molecule inhibitors, and monoclonal antibody-based compounds for personalized medicine. The present invention also relates to a method of treatment of cancer in a patient. The present invention also relates to a targeted therapy compound selected from protein kinase inhibitors, small molecule inhibitors, and monoclonal antibody-based compounds for use in a method of treatment of cancer in a patient.

Abstract: The invention relates to methods for generating multipotent mammary stem cells from isolated and cultured human breast luminal cells. The method comprises the steps: 1. isolating and growing normal differentiated cells in vitro; 2. treating the differentiated cells with either a conditioned medium from active fibroblasts or cytokine. The invention also relates to multipotent mammary stem cells, cultures of the multipotent stem cells, differentiated cells, tissues, organs derived from the culture multipotent stem cells isolated by the methods disclosed and therapeutic and other uses for those cells thereof.

Abstract: The present invention relates to methods for generating Induced Pluripotent Stem Cells from fibroblast cells. The invention also relates to appropriate culture media used by the method disclosed; pluripotent stem cells, cultures of the pluripotent stem cells, differentiated cells derived from the culture pluripotent stem cells isolated by the methods disclosed and uses for those cells, e.g. therapeutic uses, such as autologous cell therapy procedures.

Abstract: The invention relates to a surgical apparatus, in particular a navigation probe for localizing and treating lesions in a brain, comprising a telescopically expandable body member having an anterior end, a posterior end, and comprising a top part and a bottom part, the bottom part having at least one groove extending for a particular length in a longitudinal direction of the bottom part between said anterior end and said posterior end, the top part being placed on said bottom part and having at least one engaging element that extends into said at least one groove so as to mount the top part on the bottom part moveable in said longitudinal direction, wherein the body member has a substantially circular or polygonal cross-section in the assembled state of the bottom part and the upper part.

Abstract: A spinal fixation device is provided, comprising a body member having a first side and an opposite second side, and an elongate flexible strap having a first section and a second section. The first section of the strap is attached or attachable to attachment means of the body member arranged at a first location thereof. The second section of the strap is sized and shaped to pass through a passageway arranged at a second location of the body member. The strap has a series of teeth and the passageway of the body member has a latch configured for engaging one of the teeth. The teeth and the latch are configured to allow a movement of the second section of the strap through the passageway in a tightening direction from the first side to the second side of the body member, and to prevent a movement of the second section in the opposite direction.

Abstract: A fitting for receiving and fixing at least one sleeve for enforcing an end of a hollow organ so that said end of the hollow organ can be connected with a further end of the hollow organ, the fitting having a cylindrically shaped body, said body being configured to receive and hold two sleeves with turned-over hollow organ ends so that inner sides of the hollow organ ends make contact with one another.

Abstract: The invention is directed to a method for diagnosing and treating a pulmonary lung disease by detecting a mutant S100A3 protein associated with pulmonary lung disease and by treating a subject with a functional S100A3 protein.

Abstract: The invention relates to a surgical apparatus, in particular a navigation probe for localizing and treating lesions in a brain, comprising: a body member (10) having an anterior end (20), a posterior end (30) and at least one groove (60, 62) extending for a particular length in a longitudinal direction of the body member (10) between said anterior end (20) and said posterior end (30); a saddle (70) adapted to securely hold a medical device, the saddle (70) being placed on said body member (10) and having at least one grip (74, 75, 76) that extends into said at least one groove (60, 62) so as to mount the saddle (70) on the body member (10) moveable in said longitudinal direction; and a means for maneuvering said body member (10).

Abstract: The present invention relates to methods for generating Induced Pluripotent Stem Cells from fibroblast cells. The invention also relates to appropriate culture media used by the method disclosed; pluripotent stem cells, cultures of the pluripotent stem cells, differentiated cells derived from the culture pluripotent stem cells isolated by the methods disclosed and uses for those cells, e.g. therapeutic uses, such as autologous cell therapy procedures.

Abstract: A spinal fixation device is provided, comprising a body member having a first side and an opposite second side, and an elongate flexible strap having a first section and a second section. The first section of the strap is attached or attachable to attachment means of the body member arranged at a first location thereof. The second section of the strap is sized and shaped to pass through a passageway arranged at a second location of the body member. The strap has a series of teeth and the passageway of the body member has a latch configured for engaging one of the teeth. The teeth and the latch are configured to allow a movement of the second section of the strap through the passageway in a tightening direction from the first side to the second side of the body member, and to prevent a movement of the second section in the opposite direction.

Abstract: The invention is directed to a method for diagnosing and treating fibrosis, especially pulmonary fibrosis, associated with mutation of the S100A13 and S100A3 genes. Methods for detecting and distinguishing the mutant forms of these genes are disclosed and ways to compensate for loss of function or aberrant function of the mutated S100A13 or S100A3 proteins are disclosed.

Abstract: The invention is directed to a method for diagnosing and treating a pulmonary lung disease by detecting a mutant S100A3 protein associated with pulmonary lung disease and by treating a subject with a functional S100A3 protein.

Abstract: The present invention provides benzo-thiazolo-imidazole compounds and pharmaceutical compositions comprising such benzo-thiazolo-imidazole compounds and at least one pharmaceutically acceptable carrier, diluent and/or excipient. Further provided are methods of treatment of cancer comprising the administration of said compounds and compositions and methods of using said compounds and compositions for the manipulation of cultured cells.

Abstract: A spinal fixation device is provided, comprising a body member having a first side and an opposite second side, and an elongate flexible strap having a first section and a second section. The first section of the strap is attached or attachable to attachment means of the body member arranged at a first location thereof. The second section of the strap is sized and shaped to pass through a passageway arranged at a second location of the body member. The strap has a series of teeth and the passageway of the body member has a latch configured for engaging one of the teeth. The teeth and the latch are configured to allow a movement of the second section of the strap through the passageway in a tightening direction from the first side to the second side of the body member, and to prevent a movement of the second section in the opposite direction.

Abstract: The invention relates to methods for generating multipotent mammary stem cells from isolated and cultured human breast luminal cells. The method comprises the steps: 1. isolating and growing normal differentiated cells in vitro; 2. treating the differentiated cells with either a conditioned medium from active fibroblasts or cytokine. The invention also relates to multipotent mammary stem cells, cultures of the multipotent stem cells, differentiated cells, tissues, organs derived from the culture multipotent stem cells isolated by the methods disclosed and therapeutic and other uses for those cells thereof.

Abstract: A sleeve for enforcing the end of a hollow organ so that it can be connected with a further end of a hollow organ, the sleeve comprising a cylindrical shape and being configured to be pushed over the end of the hollow organ and for turning-over the end of the hollow organ projecting from the sleeve around an end of the sleeve, wherein the sleeve has an adjustable diameter.