Patents Assigned to KIST
-
Patent number: 12237651Abstract: A device for the ionization of gaseous media, comprising a feed channel (101) having a gas feed, a distribution channel (104) having at least one gas outlet, and at least one ionization unit (304), wherein the at least one ionization unit (304) is designed as a connecting channel from the feed channel (101) to the distribution channel (104) and is provided with an electrode (102) and an associated counter electrode (106). The electrode (102) is configured to ionize gas flowing through the ionization unit (304) from the feed channel (101) to the distribution channel (104), wherein the gas flows around the electrode (102), and the at least one gas outlet is designed in the form of one or more nozzles (107) or a plurality of openings (107).Type: GrantFiled: June 1, 2022Date of Patent: February 25, 2025Assignee: Kist + Eschrich GmbHInventors: Reiner Wahl, Stefan Kist, Thomas Eckardt, Scott Trimble, Alec Smith, Philip Anthony
-
Patent number: 12140594Abstract: The present invention relates to a non invasive diagnostic method of pancreatic ductal adenocarcinoma (PDAC) in a subject said method comprising the step of measuring the level of ?ig-h3 protein in a blood sample wherein the serum level of ?ig-h3 is positively correlated with the risk of having a PDAC. By following studies on 2 distinct cohorts of 20 and 104 of PDAC patients, and on PDAC mouse model, the inventors show that ?ig-h3 can be directly detected in the blood sample and ?ig-h3 is expressed very early in tumorigenesis in pancreatic neoplastic lesions. The present invention also relates to antagonist of ?ig-h3 protein, for use in the treatment of PDAC. The inventors found that ?ig-h3 bind directly on CD8+ T cells by reducing their activation and cytotoxic properties. Furthermore, the use of neutralizing ?ig-h3 antibodies in PDAC mouse model, reduced tumor growth by enhancing CD8+ T cell anti-tumoral response.Type: GrantFiled: July 7, 2023Date of Patent: November 12, 2024Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE CLAUDÉBERNARD—LYON 1, CENTRE LEON BERARD, KIST (KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY)Inventors: Kim In-San, Philippe Bertolino, Ana Hennino
-
Patent number: 12139713Abstract: Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell are described. The therapeutic compounds are configured to bind CD47 on the surface of a red blood cell and to be subsequently transferred to CD47 on the surface of the target cell, the therapeutic compound ultimately being internalized by the target cell via endocytosis. The target cell may be a cancer cell.Type: GrantFiled: January 9, 2024Date of Patent: November 12, 2024Assignees: K2B Therapeutics, Inc., KIST (Korea Institute of Science and Technology)Inventors: HoWon J. Kim, In-San Kim, Jay S. Kim, Sun Hwa Kim, Ick Chan Kwon, Jong Won Lee, Yoo Soo Yang, Hong Yeol Yoon
-
Publication number: 20240269139Abstract: The present invention relates to bifunctional compounds for targeted kinase degradation, methods for treating diseases or conditions mediated by aberrant kinase activity, and methods for identifying degradable kinases and optimal kinase:scaffold pairs.Type: ApplicationFiled: October 26, 2021Publication date: August 15, 2024Applicants: DANA-FARBER CANCER INSTITUTE, INC., Korea Institute of Science and Technology (KIST)Inventors: Nathanael S. Gray, Eric S. Fischer, Fleur M. Ferguson, Katherine Donovan, Jonathan W. Bushman, Taebo Sim, Debabrata Bhunia, SeongShick Ryu
-
Publication number: 20240266808Abstract: A device for the ionization of gaseous media, comprising a feed channel (101) having a gas feed, a distribution channel (104) having at least one gas outlet, and at least one ionization unit (304), wherein the at least one ionization unit (304) is designed as a connecting channel from the feed channel (101) to the distribution channel (104) and is provided with an electrode (102) and an associated counter electrode (106). The electrode (102) is configured to ionize gas flowing through the ionization unit (304) from the feed channel (101) to the distribution channel (104), wherein the gas flows around the electrode (102), and the at least one gas outlet is designed in the form of one or more nozzles (107) or a plurality of openings (107).Type: ApplicationFiled: June 1, 2022Publication date: August 8, 2024Applicant: KIST + ESCHERICH GMBHInventors: Reiner WAHL, Stefan KIST, Thomas ECKARDT, Scott TRIMBLE, Alec SMITH, Philip ANTHONY
-
Patent number: 12006502Abstract: Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell are described. The therapeutic compounds are configured to bind CD47 on the surface of a red blood cell and to be subsequently transferred to CD47 on the surface of the target cell, the therapeutic compound ultimately being internalized by the target cell via endocytosis. The target cell may be a fibrotic cell.Type: GrantFiled: January 9, 2024Date of Patent: June 11, 2024Assignees: K2B Therapeutics, Inc., KIST (Korea Institute of Science and Technology)Inventors: HoWon J. Kim, In-San Kim, Jay S. Kim, Sun Hwa Kim, Ick Chan Kwon, Jong Won Lee, Yoo Soo Yang, Hong Yeol Yoon
-
Patent number: 11740243Abstract: A non invasive diagnostic method of pancreatic ductal adenocarcinoma (PDAC) in a subject is provided. The method comprises the step of measuring the level of ?ig-h3 protein in a blood sample wherein the serum level of ?ig-h3 is positively correlated with the risk of having a PDAC. By following studies on 2 distinct cohorts of 20 and 104 of PDAC patients, and on PDAC mouse model, the inventors show that ?ig-h3 can be directly detected in the blood sample and ?ig-h3 is expressed very early in tumorigenesis in pancreatic neoplastic lesions. Also provided is a ?ig-h3 protein, for use in the treatment of PDAC. The inventors found that ?ig-h3 bind directly on CD8+ T cells by reducing their activation and cytotoxic properties. Furthermore, the use of neutralizing ?ig-h3 antibodies in PDAC mouse model reduced tumor growth by enhancing CD8+ T cell anti-tumoral response.Type: GrantFiled: March 15, 2017Date of Patent: August 29, 2023Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ CLAUDE BERNARD—LYON, CENTRE LEON BERARD, KIST (KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY)Inventors: Kim In-San, Philippe Bertolino, Ana Hennino
-
Patent number: 11239603Abstract: The invention relates to an electrical connector locking hub nut that does not damage the wiring during pulling, frees up manpower by allowing one person rather than two to be able to do the pulling, has a simplified design, and which has universal threading for conduit of all currently approved sizes and materials.Type: GrantFiled: February 7, 2018Date of Patent: February 1, 2022Assignee: KIST CORP.Inventor: Rifet Spahic
-
Patent number: 10113230Abstract: The present disclosure relates to a method of producing a multilayer hexagonal boron nitride (h-BN) thick film on a substrate, and more particularly, to a method of forming a multilayer h-BN thick film on a substrate including (a) a substrate heating step of heating a first substrate, (b) a h-BN precursor supply step of supplying h-BN precursors to the heated first substrate, (c) a precursor dissolving step of dissolving the supplied h-BN precursors in the first substrate, and (d) a substrate cooling step of cooling the first substrate containing the dissolved h-BN precursors therein, and a laminate including a multilayer h-BN thick film prepared by the preparation method and a substrate which forms a stack structure with the h-BN thick film.Type: GrantFiled: February 26, 2016Date of Patent: October 30, 2018Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KIST)Inventors: Soo-Min Kim, Ki-Kang Kim, Joo-Song Lee
-
Patent number: 9526699Abstract: The present invention relates to a biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances. According to the present invention, poly(organophosphazene) is a phosphagen-based polymer showing biodegradability, thermosensitivity, and sol-gel phase transition depending on temperature change, whereby when administered into a living body with bioactive substances such as drugs, the poly(organophosphazene) forms a gel-phase at body temperature to be capable of controlled release of the bioactive substances. Further, the poly(organophosphazene) has functional groups to chemically bind with bioactive substances through an ionic bond, covalent bond, or coordinate covalent bond to be capable of a sustained release of the bioactive substances due to its good binding property. Therefore, the poly(organophosphazene) is useful as a delivery material for bioactive substances.Type: GrantFiled: November 3, 2006Date of Patent: December 27, 2016Assignee: KISTInventors: Soo-Chang Song, Sun-Mi Lee, Chang-Won Kim, Mi-Ran Park
-
Publication number: 20160281221Abstract: The present disclosure relates to a method of producing a multilayer hexagonal boron nitride (h-BN) thick film on a substrate, and more particularly, to a method of forming a multilayer h-BN thick film on a substrate including (a) a substrate heating step of heating a first substrate, (b) a h-BN precursor supply step of supplying h-BN precursors to the heated first substrate, (c) a precursor dissolving step of dissolving the supplied h-BN precursors in the first substrate, and (d) a substrate cooling step of cooling the first substrate containing the dissolved h-BN precursors therein, and a laminate including a multilayer h-BN thick film prepared by the preparation method and a substrate which forms a stack structure with the h-BN thick filmType: ApplicationFiled: February 26, 2016Publication date: September 29, 2016Applicant: Korea Institute of Science and Technology (KIST)Inventors: Soo-Min KIM, Ki-Kang KIM, Joo-Song Lee
-
Patent number: 9238085Abstract: A metering device for metered dispensing of liquid preparations, in particular for metering medicinal, pharmaceutical and cosmetic liquid preparations, the use of preservatives being able to be dispensed with.Type: GrantFiled: March 4, 2009Date of Patent: January 19, 2016Assignees: KIST-Europe Forschungsgesellschaft mbH, F. Holzer GmbHInventors: Hyeck-Hee Lee, Ute Steinfeld, Chang-Ho Kim, Jungtae Kim, Holger Krause
-
Patent number: 8871950Abstract: The present invention relates to a method for preparing (+)-polyoxamic acid and a novel intermediate compound synthesized during preparation thereof. The preparation method according to the present invention allows preparation of (+)-polyoxamic acid with high optical purity in high yield. In particular, the preparation method is useful for mass production because the process is simple.Type: GrantFiled: October 29, 2013Date of Patent: October 28, 2014Assignee: Korea Institute of Science and Technology (KIST)Inventors: Tae Bo Sim, Ho Jong Yoon, Eun Joo Roh
-
Publication number: 20140099641Abstract: The present invention relates to primer sets for diagnosing ankylosing spondylitis and the method for diagnosing ankylosing spondylitis using the same. Particularly, the present invention provides primer sets for diagnosing ankylosing spondylitis as follows: (a) a primer set comprising a primer having at least 95% sequence homology with SEQ ID NO: 7, and at least one primer selected from the group consisting of primers of SEQ ID NOs: 9 to 13; (b) a primer set comprising at least one primer selected from the group consisting of primers of SEQ ID NOs: 15 to 17, and a primer having at least 95% sequence homology with SEQ ID NO: 19 and (c) a primer set comprising a primer having at least 95% sequence homology with SEQ ID NO: 18, and a primer having at least 95% sequence homology with SEQ ID NO: 20. The primer sets and the kit for diagnosing ankylosing spondylitis of the present invention can be effectively used for early diagnosis. tracking progress and prognosis of ankylosing spondylitis.Type: ApplicationFiled: January 6, 2011Publication date: April 10, 2014Applicant: KIST-EUROPE FGMBHInventors: Chang Hoon Nam, Yeon Joo Kim, Han-Joo Back
-
Patent number: 8550300Abstract: An embodiment of the present invention relates to a storage container for liquids or for viscous or atomizable products, which can be connected to a metering device, the storage container having a cylindrical configuration and a base with a pressure equalization device and also an oppositely situated open side, the open side including a connection region, and in that an inner bag which is collapsible by suction force is disposed in the storage container.Type: GrantFiled: May 12, 2010Date of Patent: October 8, 2013Assignees: KIST—Europe Forschungsgesellschaft mbH, F. Holzer GmbHInventors: Hyeck-Hee Lee, Ute Steinfeld, Jungtae Kim, Holger Krause
-
Publication number: 20130240180Abstract: System and method for for superheating and/or supercooling of liquids and use of the system and/or method, wherein the liquid is within a capillary tube, wherein there is at least one heating and/or cooling means for heating the liquid above boiling point of the liquid at ambient pressure or cooling the liquid below freezing point of the liquid at ambient pressure, wherein the at least one heating and/or cooling means is in thermal contact with the capillary tube in an area, in which there is liquid inside the capillary tube, and wherein the capillary tube is scratch-free at its inner surface.Type: ApplicationFiled: March 13, 2013Publication date: September 19, 2013Applicant: Kist Europe-Korea Institute of Science and Technologie Europe Forschungsgesellschaft mbhInventor: Kist Europe-Korea Institute of Science and Technologie Europe Forschungsgesellschaft mbh
-
Publication number: 20130043273Abstract: The present invention relates to a metering device for metered output of liquid preparations in the medicinal, pharmaceutical or cosmetic field or in the foodstuffs sphere, the use of preservatives being able to be dispensed with. Furthermore, the invention relates to a method for filling and also the use of a metering device according to the invention.Type: ApplicationFiled: September 9, 2010Publication date: February 21, 2013Applicant: KIST-EUROPE FORSCHUNGSGESELLSCHAFT MBHInventors: Hyeck Hee Lee, Ute Steinfeld, Jungtae Kim, Holger Krause, Jihwang Park, Kwang Ho Kim, Bianca Schweiger, Sebastian Beck
-
Publication number: 20110318777Abstract: The invention relates to a device for metering cells and also to a method for metering cells. Furthermore, the invention relates to the use of the device for metering cells.Type: ApplicationFiled: June 9, 2011Publication date: December 29, 2011Applicant: KIST-EUROPE FORSCHUNGSGESELLSCHAFT MBHInventors: Jungtae Kim, Holger Krause, Jihwang Park, Sebastian Beck
-
Publication number: 20110056993Abstract: The present invention relates to a metering device for metered dispensing of liquid preparations, in particular for metering medicinal, pharmaceutical and cosmetic liquid preparations, the use of preservatives being able to be dispensed with.Type: ApplicationFiled: March 4, 2009Publication date: March 10, 2011Applicant: KIST-Europe Forschungsgesellschaft mbHInventors: Hyeck-Hee Lee, Ute Steinfeld, Chang-Ho Kim, Jungtae Kim, Holger Krause
-
Publication number: 20100287891Abstract: An embodiment of the present invention relates to a storage container for liquids or for viscous or atomisable products, which can be connected to a metering device, the storage container having a cylindrical configuration and a base with a pressure equalisation device and also an oppositely situated open side, the open side including a connection region, and in that an inner bag which is collapsible by suction force is disposed in the storage container.Type: ApplicationFiled: May 12, 2010Publication date: November 18, 2010Applicants: KIST-Europe Forschungsgesellschaft mbH, F. Holzer GmbHInventors: Hyeck-Hee Lee, Ute Steinfeld, Jungtae Kim, Holger Krause