Patents Assigned to KIST
  • Patent number: 9526699
    Abstract: The present invention relates to a biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances. According to the present invention, poly(organophosphazene) is a phosphagen-based polymer showing biodegradability, thermosensitivity, and sol-gel phase transition depending on temperature change, whereby when administered into a living body with bioactive substances such as drugs, the poly(organophosphazene) forms a gel-phase at body temperature to be capable of controlled release of the bioactive substances. Further, the poly(organophosphazene) has functional groups to chemically bind with bioactive substances through an ionic bond, covalent bond, or coordinate covalent bond to be capable of a sustained release of the bioactive substances due to its good binding property. Therefore, the poly(organophosphazene) is useful as a delivery material for bioactive substances.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: December 27, 2016
    Assignee: KIST
    Inventors: Soo-Chang Song, Sun-Mi Lee, Chang-Won Kim, Mi-Ran Park
  • Publication number: 20090022683
    Abstract: The present invention relates to a biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances. According to the present invention, poly(organophosphazene) is a phosphagen-based polymer showing biodegradability, thermosensitivity, and sol-gel phase transition depending on temperature change, whereby when administered into a living body with bioactive substances such as drugs, the poly(organophosphazene) forms a gel-phase at body temperature to be capable of controlled release of the bioactive substances. Further, the poly(organophosphazene) has functional groups to chemically bind with bioactive substances through an ionic bond, covalent bond, or coordinate covalent bond to be capable of a sustained release of the bioactive substances due to its good binding property. Therefore, the poly(organophosphazene) is useful as a delivery material for bioactive substances.
    Type: Application
    Filed: November 3, 2006
    Publication date: January 22, 2009
    Applicant: KIST
    Inventors: Soo-Chang Song, Sun-Mi Lee, Chang-Won Kim, Mi-Ran Park
  • Patent number: 7468122
    Abstract: The present invention relates to a composite layer including a metal and inorganic powders, and a method for manufacturing the same. The method for manufacturing a composite layer including a metal and inorganic powders includes step of preparing an electrolyte which includes nickel sulfamate [Ni(NH2SO4)] at 50.0 g/l˜300.0 g/l, boric acid at 10.0 g/l˜20.0 g/l, nickel chloride (NiCl2) at 1.0 g/l˜10.0 g/l, coumarin (C9H6O2) at 0.02 g/l˜0.5 g/l, sodium dodecyl sulfate [CH3—(CH2)11—OSONa] at 4.0 g/l˜60.0 g/l, sulfuric acid at 0.0 ml/l˜150.0 ml/l, one or more inorganic powders selected from the group of alumina (Al2O3) and silicon carbide (SiC) at 20.0 g/l˜70.0 g/l, and the remainder being distilled water. A basic metal to be coated with the composite metal is dipped into the electrolyte, and power is applied to the basic metal to electroplate the basic metal with the electrolyte to form a composite layer on the basic metal.
    Type: Grant
    Filed: December 29, 2005
    Date of Patent: December 23, 2008
    Assignee: KIST
    Inventors: Ji-Young Byun, Kyung-Tae Hong, Jung-Man Doh, Heon-Phil Ha, Kyoung-Tae Kim