Abstract: A non invasive diagnostic method of pancreatic ductal adenocarcinoma (PDAC) in a subject is provided. The method comprises the step of measuring the level of ?ig-h3 protein in a blood sample wherein the serum level of ?ig-h3 is positively correlated with the risk of having a PDAC. By following studies on 2 distinct cohorts of 20 and 104 of PDAC patients, and on PDAC mouse model, the inventors show that ?ig-h3 can be directly detected in the blood sample and ?ig-h3 is expressed very early in tumorigenesis in pancreatic neoplastic lesions. Also provided is a ?ig-h3 protein, for use in the treatment of PDAC. The inventors found that ?ig-h3 bind directly on CD8+ T cells by reducing their activation and cytotoxic properties. Furthermore, the use of neutralizing ?ig-h3 antibodies in PDAC mouse model reduced tumor growth by enhancing CD8+ T cell anti-tumoral response.
Type:
Grant
Filed:
March 15, 2017
Date of Patent:
August 29, 2023
Assignees:
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ CLAUDE BERNARD—LYON, CENTRE LEON BERARD, KIST (KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY)
Inventors:
Kim In-San, Philippe Bertolino, Ana Hennino
Abstract: An internal reforming molten carbonate fuel cell having a membrane for intercepting carbonate vapor and hydrated vapor is disclosed. The intercepting membrane is made from nickel or nickel alloy which has a high electrical conductivity, corrosion resistant property in an anode environment, and a low affinity for the carbonate vapor. Due to the presence of the intercepting membrane, the transfer of the carbonate vapors and hydrated vapors to the internal reforming catalyst is markedly retarded to prolong the catalytic activity. As a result, a longer operating molten carbonate fuel cell can be obtained.
Type:
Grant
Filed:
January 16, 2001
Date of Patent:
April 8, 2003
Assignee:
KIST (Korea Institute of Science and Technology
Inventors:
Tae Hoon Lim, Heung Yong Ha, Suk Woo Nam, In Hwan Oh, Seong Ahn Hong, Hyeung Dae Moon, Ho In Lee
Abstract: An internal reforming molten carbonate fuel cell having a membrane for intercepting carbonate vapor and hydrated vapor is disclosed. The intercepting membrane is made from nickel or nickel alloy which has a high electrical conductivity, corrosion resistant property in an anode environment, and a low affinity for the carbonate vapor. Due to the presence of the intercepting membrane, the transfer of the carbonate vapors and hydrated vapors to the internal reforming catalyst is markedly retarded to prolong the catalytic activity. As a result, a longer operating molten carbonate fuel cell can be obtained.
Type:
Application
Filed:
January 16, 2001
Publication date:
October 4, 2001
Applicant:
KIST ( Korea Institute of Science and Technology)
Inventors:
Tae Hoon Lim, Heung Yong Ha, Suk Woo Nam, In Hwan Oh, Seong Ahn Hong, Hyeung Dae Moon, Ho In Lee