Patents Assigned to Kiyoshi Kurokawa
  • Carbonyl stress-decreasing agent
    Patent number: 7169407
    Abstract: The present invention provides agents that decrease carbonyl stress comprising biguanides, such as metoformin. Through oral administration and such, the carbonyl stress-decreasing agents of the present invention are useful as drugs directly acting against carbonyl stress in vivo.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: January 30, 2007
    Assignees: Kiyoshi Kurokawa, Tokai University Educational System
    Inventor: Toshio Miyata
  • Megsin promoter
    Patent number: 6790617
    Abstract: Genomic DNA region including the about 1.5 kb upstream region of MEGSIN gene was isolated and its nucleotide sequence was determined. In the genomic DNA region, two regulatory sequences that regulate the transcription positively were identified. Furthermore, nucleotide substitutions were introduced in the promoter regions located at the 3′ sites of the two regulatory sequences by site specific mutagenesis, and the nucleotide sequences that play important roles in the promoter activity were successfully identified.
    Type: Grant
    Filed: October 16, 2001
    Date of Patent: September 14, 2004
    Assignees: Toshio Miyata, Kiyoshi Kurokawa
    Inventor: Toshio Miyata