Abstract: Novel (E)-1-[4'-(2-alkylaminoethoxy)phenyl]-1- (3'-hydroxyphenyl)-2-phenylbut-1-enes of the general formula ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different, provided that, when R.sup.1 and R.sup.2 are the same, each of them is a methyl or ethyl radical, and when R.sup.1 and R.sup.2 are different, one of them is hydrogen and the other is a methyl or ethyl radical, and the therapeutically compatible salts thereof, have a marked anti-estrogenic effect and are suitable for treating hormone-dependent mammary tumors.The compounds can be prepared by dehydrating carbinols of the general formula ##STR2## wherein R.sup.1 and R.sup.2 may be the same or different, provided that, when R.sup.1 and R.sup.2 are the same, each of them is a methyl or ethyl radical, and when R.sup.1 and R.sup.2 are different, one of them is a benzyl radical and the other is a methyl or ethyl radical; and wherein R.sup.
Type:
Grant
Filed:
May 14, 1990
Date of Patent:
September 10, 1991
Assignee:
Klinge Pharma GmbH & Co.
Inventors:
Helmut Schickaneder, Roland Loser, Helmut Grill
Abstract: New 1,3-disubstituted propanol-(2) derivatives and their nicotinic acid esters of the general formula ##STR1## and their therapeutically acceptable salts, processes for preparing the same and the use thereof and pharmaceutical preparations containing the same for the treatment of hyperlipemia.
Type:
Grant
Filed:
November 9, 1977
Date of Patent:
March 13, 1979
Assignee:
Klinge Pharma GmbH & Co.
Inventors:
Helmut Grill, Rainer H. Zschocke, Josef Wagner, Gernot Hofrichter, P. Stefan Janiak
Abstract: New 1,3-disubstituted propanol-(2) derivatives and their nicotinic acid esters of the general formula ##STR1## and their therapeutically acceptable salts, processes for preparing the same and the use thereof and pharmaceutical preparations containing the same for the treatment of hyperlipemia.
Type:
Grant
Filed:
November 9, 1977
Date of Patent:
August 22, 1978
Assignee:
Klinge Pharma GmbH & Co.
Inventors:
Helmut Grill, Rainer Hans Zschocke, Josef Wagner, Gernot Hofrichter, P. Stefan Janiak
Abstract: New 1,3-disubstituted propanol-(2) derivatives and their nicotinic acid esters of the general formula ##STR1## and their therapeutically acceptable salts, processes for preparing the same and the use thereof and pharmaceutical preparations containing the same for the treatment of hyperlipemia.
Type:
Grant
Filed:
December 18, 1975
Date of Patent:
February 14, 1978
Assignee:
Klinge Pharma GmbH & Co.
Inventors:
Helmut Grill, Rainer H. Zschocke, Josef Wagner, Gernot Hofrichter, P. Stefan Janiak