Patents Assigned to Klinge Pharma GmbH & Co.
  • Patent number: 5047431
    Abstract: Novel (E)-1-[4'-(2-alkylaminoethoxy)phenyl]-1- (3'-hydroxyphenyl)-2-phenylbut-1-enes of the general formula ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different, provided that, when R.sup.1 and R.sup.2 are the same, each of them is a methyl or ethyl radical, and when R.sup.1 and R.sup.2 are different, one of them is hydrogen and the other is a methyl or ethyl radical, and the therapeutically compatible salts thereof, have a marked anti-estrogenic effect and are suitable for treating hormone-dependent mammary tumors.The compounds can be prepared by dehydrating carbinols of the general formula ##STR2## wherein R.sup.1 and R.sup.2 may be the same or different, provided that, when R.sup.1 and R.sup.2 are the same, each of them is a methyl or ethyl radical, and when R.sup.1 and R.sup.2 are different, one of them is a benzyl radical and the other is a methyl or ethyl radical; and wherein R.sup.
    Type: Grant
    Filed: May 14, 1990
    Date of Patent: September 10, 1991
    Assignee: Klinge Pharma GmbH & Co.
    Inventors: Helmut Schickaneder, Roland Loser, Helmut Grill
  • Patent number: 4144351
    Abstract: New 1,3-disubstituted propanol-(2) derivatives and their nicotinic acid esters of the general formula ##STR1## and their therapeutically acceptable salts, processes for preparing the same and the use thereof and pharmaceutical preparations containing the same for the treatment of hyperlipemia.
    Type: Grant
    Filed: November 9, 1977
    Date of Patent: March 13, 1979
    Assignee: Klinge Pharma GmbH & Co.
    Inventors: Helmut Grill, Rainer H. Zschocke, Josef Wagner, Gernot Hofrichter, P. Stefan Janiak
  • Patent number: 4109013
    Abstract: New 1,3-disubstituted propanol-(2) derivatives and their nicotinic acid esters of the general formula ##STR1## and their therapeutically acceptable salts, processes for preparing the same and the use thereof and pharmaceutical preparations containing the same for the treatment of hyperlipemia.
    Type: Grant
    Filed: November 9, 1977
    Date of Patent: August 22, 1978
    Assignee: Klinge Pharma GmbH & Co.
    Inventors: Helmut Grill, Rainer Hans Zschocke, Josef Wagner, Gernot Hofrichter, P. Stefan Janiak
  • Patent number: 4073935
    Abstract: New 1,3-disubstituted propanol-(2) derivatives and their nicotinic acid esters of the general formula ##STR1## and their therapeutically acceptable salts, processes for preparing the same and the use thereof and pharmaceutical preparations containing the same for the treatment of hyperlipemia.
    Type: Grant
    Filed: December 18, 1975
    Date of Patent: February 14, 1978
    Assignee: Klinge Pharma GmbH & Co.
    Inventors: Helmut Grill, Rainer H. Zschocke, Josef Wagner, Gernot Hofrichter, P. Stefan Janiak