Patents Assigned to KLINIKUM DARMSTADT GMBH
  • COMPOUNDS FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISORDERS ON THE OLFACTORY EPITHELIUM
    Publication number: 20130287700
    Abstract: Subject of the present invention are compounds with high affinity for the A? protein, ?-synuclein or for Tau-PHF aggregates, which are suitable as preferably fluorescent probes for the in vivo diagnosis of neurodegenerative disorders like e.g. Alzheimer's disease and Parkinson's disease. The compounds are characterized by suitable physicochemical properties (excitation wavelength, emission wavelength, Stokes shift, extinction) as well as a high affinity and selectivity for the target proteins.
    Type: Application
    Filed: September 20, 2011
    Publication date: October 31, 2013
    Applicants: KLINIKUM DARMSTADT GMBH, TECHNISCHE UNIVERSITAT DARMSTADT, LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN
    Inventors: Boris Schmidt, Daniel Kieser, Alexander Boländer, Jochen Herms, Roland Heyny-Von Haussen, Jiamin Gu