Abstract: 2-pyrrolidinone derivatives which have in position 4 at least one substituent are described herein. Methods of treating polygltamine disorders such as Huntington's disease, dentorubropallidoluysian atrophy (DRPLA), spinal and bulbar muscular atrophy (SBMA), and spinocerebellar ataxias with 2-pyrrolidinone derivatives are also descibed.

Abstract: 2-pyrrolidinone derivatives which have in position 4 at least one substituent are described herein. Methods of treating polyglutamine disorders such as Huntington's disease, dentorubropallidoluysian atrophy (DRPLA), spinal and bulbar muscular atrophy (SBMA), and spinocerebellar ataxias with 2-pyrrolidinone derivatives are also descibed.

Abstract: 2-Pyrrolidinone derivatives substituted in position 4 are provided according to the invention for use as therapeutic active ingredient. It has been found, surprisingly, that these compounds are able markedly to reduce the extracellular glutamate level, and the compounds are therefore suitable for the prophylaxis and treatment of a large number of disorders, in particular, stroke.

Abstract: A method of spatially resolved magnetic resonance spectroscopy according to the principle of chemical shift imaging (=CSI) in which, through application of an excitation pulse, spins in a measuring volume are excited and a metabolite signal thereof is read out, wherein between the excitation pulse and the recording of the signal, spatial encoding of the signal is effected by means of a gradient pulse in at least one spatial direction, wherein said spatial encoding gradient is varied between each recording step, such that one obtains spatial allocation of the recorded signals in the partial volume of the measuring volume, is characterized in that a reference signal is recorded in addition to the signal of the recorded metabolites, which comprises the same spatial encoding as the metabolite signal, wherein the recording of the two signals is effected in a convoluted manner.