Abstract: A microscopy system and method allow observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.
Type:
Grant
Filed:
March 28, 2011
Date of Patent:
October 30, 2012
Assignees:
Carl Zeiss Meditec AG, Klinikum der Johann Wolfgang Goethe Universitaet Frankfurt
Inventors:
Michael Haisch, Christoph Hauger, Harmut Wolf, Joachim Hug, Schwarz Brigitta
Abstract: A microscopy system and a microscopy method are provided for observing a fluorescent substance accumulated in a tissue. The microscopy system comprises a filter allowing to observe the tissue at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series.
Type:
Application
Filed:
May 24, 2012
Publication date:
October 4, 2012
Applicants:
Klinikum der Johann Wolfgang Goethe Universitaet Frankfurt, CARL ZEISS MEDITEC AG
Inventors:
Michael Haisch, Christoph HAUGER, Hartmut WOLF, Joachim HUG, Schwarz Brigitta, Gerhard Gaida, Andreas Raabe
Abstract: A microscopy system and a microscopy method are provided for observing a fluorescent substance accumulated in a tissue. The microscopy system comprises a filter allowing to observe the tissue at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.
Type:
Application
Filed:
August 28, 2003
Publication date:
June 10, 2004
Applicants:
Carl-Zeiss-Stiftung trading as Carl Zeiss, Klinikum der Johann Wolfgang Goethe Universitaet Frankfurt
Inventors:
Michael Haisch, Christoph Hauger, Hartmut Wolf, Joachim Hug, Schwarz Brigitta, Gerhard Gaida, Andreas Raabe