Abstract: The invention relates to an implantable device for the non-pneumatic adjustable positioning of a human or animal body part, comprising a) at least one elastic element and, optionally, b) an abutment, as well as the use of this device in a method for the treatment of disorders that are caused by the deficient or inadequate positioning of a human or animal body part. In particular, the invention relates to the use of the device for treating sleep-related breathing disorders.

Abstract: The present application relates to a nucleic acid molecule having a nucleotide sequence encoding a bifunctional polypeptide comprising the DNA-binding domain of a protein belonging to the family of Methyl-CpG binding proteins (MBDs) and the Fc portion of an antibody. In addition, vectors and host cells which comprise said nucleic acid molecule and polypeptides which are encoded by said nucleic acid molecule as well as processes for producing said polypeptide are disclosed. Moreover, the present application provides an antibody specifically binding said polypeptide and compositions, in particular diagnostic compositions comprising the nucleic acid molecule(s), vector(s), host cell(s), polypeptide(s) or antibodie(s) of the present application. Furthermore, methods and uses employing the polypeptides of the present invention for detecting methylated DNA, in particular in tumorous tissue or tumor cells are provided.