Abstract: Non-naturally occurring microorganisms are provided that produce C40 carotenoid compound(s), utilizing exogenously added enzyme activities. Methods of producing C40 carotenoid compounds in microbial cultures, and feed and nutritional supplement compositions that include the C40 carotenoid compounds produced in the microbial cultures, are also provided.
Type:
Grant
Filed:
May 31, 2018
Date of Patent:
January 24, 2023
Assignee:
KNIPBIO, INC.
Inventors:
Lawrence F. Feinberg, Daniel R. Smith, Bonnie D. McAvoy, Catherine J. Pujol-Baxley, Christopher J. Marx
Abstract: Non-naturally occurring microorganisms are provided that produce taurine and/or taurine precursors, e.g., hypotaurine, sulfoacetaldehyde, or cysteate, utilizing exogenously added enzyme activities. Methods of producing taurine and/or taurine precursors in microbial cultures, and feed and nutritional supplement compositions that include taurine and/or taurine precursors produced in the microbial cultures, such as taurine- and/or taurine precursor-containing biomass, are also provided.
Type:
Grant
Filed:
November 9, 2016
Date of Patent:
May 10, 2022
Assignee:
KnipBio, Inc.
Inventors:
Lawrence F. Feinberg, Christopher J. Marx, Max A. Wall, Daniel R. Smith, Catherine J. Pujol-Baxley, Bonnie D. McAvoy
Abstract: Disclosed are methods of producing carotenoid compounds in a methylotrophic bacterial host cell. Such a host cell may be an unmodified Methylobacterium, spontaneous mutant, or transformed cell, any of which exhibit favorable properties, such as overproduction of carotenoid compounds, increased carbon flux, improved growth, or the production of additional nutrients, such as protein, vitamins, antioxidants, or fatty acids. Also disclosed are feed compositions for use in aquaculture, or as animal feed, or as human nutritional supplements containing processed or unprocessed biomass from such cells, as are methods of preparation of the feed compositions.
Abstract: Non-naturally occurring microorganisms are provided that produce taurine and/or taurine precursors, e.g., hypotaurine, sulfoacetaldehyde, or cysteate, utilizing exogenously added enzyme activities. Methods of producing taurine and/or taurine precursors in microbial cultures, and feed and nutritional supplement compositions that include taurine and/or taurine precursors produced in the microbial cultures, such as taurine- and/or taurine precursor-containing biomass, are also provided.
Type:
Application
Filed:
November 9, 2016
Publication date:
February 28, 2019
Applicant:
KnipBio, Inc.
Inventors:
Lawrence F. Feinberg, Christopher J. Marx, Max A. Wall, Daniel R. Smith, Catherine J. Pujol-Baxley, Bonnie D. McAvoy