Abstract: What is disclosed is an enzyme system cleaving fibrinogen, said system comprising a fibrinogenase and a water-soluble polysaccharide.

Abstract: Alkylenedioxy piperazine compounds of the formula ##STR1## and salts thereof with physiologically tolerated acids, useful for the treatment of vascular and cardiac diseases, are disclosed, as are methods for making the compounds and pharmaceutical compositions containing the compounds.

Abstract: Piperazine compounds of the formula ##STR1## and salts thereof with physiologically tolerable acids useful for the treatment of vascular and cardiac diseases, are disclosed, as are methods for making the compounds and pharmaceutical compositions containing the compounds.

Abstract: Cardioactive 3-methyl-3-(3,4-dialkoxybenzyl)-piperazine compounds of the formula ##STR1## and their salts with physiologically tolerable acids; methods for making the same; pharmaceutical compositions containing the compounds as an active ingredient; and methods of treating cardiac diseases such as arrhythmia with said compounds.

Abstract: Isoquinoline compounds having .beta.-receptor blocking activity, particularly for the heart, and having the formula ##STR1## and salts thereof with physiologically tolerable acids, wherein R.sub.1 is hydrogen or methyl, R.sub.2 is hydrogen or lower alkyl, R.sub.3 is hydrogen or methoxy, and R.sub.4 is isopropyl or tertiary butyl. A method for making such compounds. Pharmaceutical compositions containing such compounds.

Abstract: Methods of treating cardiac arrhythmia by the oral or parenteral administration of N,N'-dibenzyl-alkylene diamine compounds of the formula ##STR1## or salts thereof with pharmaceutically acceptable acids, wherein A, B, D, and E are hydrogen, chlorine, or methoxy, and n is 2, 3, or 4; therapeutic compositions containing these anti-arrhythmic agents in combination with a pharmaceutical excipient.

Abstract: Cardioactive glycosides of the formula ##STR1## are disclosed, wherein R.sub.1 is saturated aliphatic hydrocarbon having 1 - 4 carbon atoms or unsaturated aliphatic hydrocarbon having 2 - 4 carbon atoms or phenyl and R.sub.2 is hydrogen or hydroxyl, as are methods for making the same by reacting the corresponding aglycone with an acylated 1-halo-hexopyranose of the formula ##STR2## wherein Hal is halogen, R.sub.3 is hydrogen or alkanoyloxy having 1 - 4 carbon atoms, and R.sub.4 is alkanoyl having 1 - 4 carbon atoms or benzoyl, and subsequently cleaving the acyl groups.

Abstract: Cardioactive 3-methyl-3-(3,4-dialkoxybenzyl)-piperazine compounds of the formula ##STR1## and their salts with physiologically tolerable acids; methods for making the same; pharmaceutical compositions containing the compounds as an active ingredient; and methods of treating cardiac diseases such as arrhythmia with said compounds.

Abstract: Cardioactive bispidones and bispidines of the formula ##SPC1##Wherein R is =C=O or --CH.sub.2 -- and R' and R" are alkyl mono- or di-substituted by phenyl, made by a Mannich reaction from formaldehyde, piperidones of the formula ##SPC2##And amines of the formula R"--NH.sub.2.

Abstract: Basically substituted phenylacetonitriles having also a trifluoromethyl substituent. The compounds are useful as coronary dilators.

Abstract: Novel cardenolides having desirable cardiac activity and which are readily reabsorbed internally, a process for their preparation and therapeutic compositions containing said cardenolides are disclosed.