Patents Assigned to Knopp Neurosciences, Inc.
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Publication number: 20140100372Abstract: Methods for preparing chirally purified substituted 4,5,6,7-tetrahydro-benzothiazole diamines such as, for example, (6R)2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole and purifying a dominant enantiomer of substituted 4,5,6,7-tetrahydro-benzothiazole diamines from entantiomerically enriched mixtures of substituted 4,5,6,7-tetrahydro-benzothiazole diamines are provided herein.Type: ApplicationFiled: August 22, 2013Publication date: April 10, 2014Applicant: KNOPP NEUROSCIENCES, INC.Inventors: Prasad RAJE, Rajendrakumar Reddy GADIKOTA, Jian-Xie CHEN, Olga V. LAPINA, John M. McCALL
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Publication number: 20130310430Abstract: Pharmaceutical compositions of (R)-pramipexole and methods and kits of using such compositions for the treatment of neurodegenerative diseases, or those related to mitochondrial dysfunction or increased oxidative stress are disclosed.Type: ApplicationFiled: July 15, 2013Publication date: November 21, 2013Applicant: KNOPP NEUROSCIENCES, INC.Inventors: Michael E. BOZIK, Thomas PETZINGER, JR., Valentin GRIBKOFF
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Publication number: 20130245081Abstract: Pharmaceutical compositions of dexpramipexole and methods of using such compositions for the treatment of ALS are disclosed.Type: ApplicationFiled: December 20, 2012Publication date: September 19, 2013Applicant: Knopp Neurosciences, Inc.Inventors: Valentin Gribkoff, Michael E. Bozik
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Publication number: 20130230569Abstract: Compositions of predetermined amounts of R(+) pramipexole and S(?) pramipexole and methods of using the same, including for the treatment and prevention of Parkinson's disease, are provided.Type: ApplicationFiled: April 12, 2013Publication date: September 5, 2013Applicant: KNOPP NEUROSCIENCES, INC.Inventors: Michael E. BOZIK, Thomas PETZINGER, Valentin GRIBKOFF
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Patent number: 8524695Abstract: Modified release pharmaceutical compositions (controlled release, sustained release, and/or extended release) of the R-(+) enantiomer of pramipexole (RPPX) and methods of using such compositions for the treatment of neurodegenerative diseases, or those related to mitochondrial dysfunction or increased oxidative stress are disclosed.Type: GrantFiled: March 14, 2008Date of Patent: September 3, 2013Assignee: Knopp Neurosciences, Inc.Inventors: Michael E. Bozik, Thomas Petzinger, Jr., Valentin Gribkoff
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Patent number: 8518926Abstract: Pharmaceutical compositions of (R)-pramipexole and methods and kits of using such compositions for the treatment of neurodegenerative diseases, or those related to mitochondrial dysfunction or increased oxidative stress are disclosed.Type: GrantFiled: December 14, 2007Date of Patent: August 27, 2013Assignee: Knopp Neurosciences, Inc.Inventors: Michael E. Bozik, Thomas Petzinger, Jr., Valentin Gribkoff
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Patent number: 8519148Abstract: Methods for preparing chirally purified substituted 4,5,6,7-tetrahydro-benzothiazole diamines such as, for example, (6R)2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole and purifying a dominant enantiomer of substituted 4,5,6,7-tetrahydro-benzothiazole diamines from entantiomerically enriched mixtures of substituted 4,5,6,7-tetrahydro-benzothiazole diamines are provided herein.Type: GrantFiled: March 14, 2008Date of Patent: August 27, 2013Assignee: Knopp Neurosciences, Inc.Inventors: Prasad Raje, Rajendrakumar Reddy Gadikota, Jian-Xie Chen, Olga V. Lapina, John M. McCall
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Patent number: 8445474Abstract: Compositions of predetermined amounts of R(+) pramipexole and S(?) pramipexole and methods of using the same, including for the treatment and prevention of Parkinson's disease, are provided.Type: GrantFiled: August 5, 2011Date of Patent: May 21, 2013Assignee: Knopp Neurosciences, Inc.Inventors: Michael E. Bozik, Thomas Petzinger, Jr., Valentin Gribkoff
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Publication number: 20130123312Abstract: Pharmaceutical compositions of R(+) pramipexole and methods of using such compositions for the treatment or prevention of diseases associated with or related to mitochondrial dysfunction or increased oxidative stress are disclosed.Type: ApplicationFiled: December 20, 2012Publication date: May 16, 2013Applicant: Knopp Neurosciences Inc.Inventor: Knopp Neurosciences Inc.
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Publication number: 20130079526Abstract: Methods for preparing chirally purified substituted 4,5,6,7-tetrahydro-benzothiazole diamines such as, for example, (6R)2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole and purifying a dominant enantiomer of substituted 4,5,6,7-tetrahydro-benzothiazole diamines from entantiomerically enriched mixtures of substituted 4,5,6,7-tetrahydro-benzothiazole diamines are provided herein.Type: ApplicationFiled: March 3, 2011Publication date: March 28, 2013Applicant: Knopp Neurosciences Inc.Inventors: Scott Jeffrey Greenfield, Cameron Seath Gibb, Rajendra Kumar Reddy Gadikota
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Publication number: 20120225915Abstract: Pharmaceutical compositions of R(+) pramipexole and methods of using such compositions for the treatment or prevention of diseases associated with or related to mitochondrial dysfunction or increased oxidative stress are disclosed.Type: ApplicationFiled: May 9, 2012Publication date: September 6, 2012Applicant: Knopp Neurosciences Inc.Inventors: Michael E. Bozik, Gregory T. Hebrank, Thomas Petzinger, JR.
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Publication number: 20110293718Abstract: Compositions of predetermined amounts of R(+) pramipexole and S(?) pramipexole and methods of using the same, including for the treatment and prevention of Parkinson's disease, are provided.Type: ApplicationFiled: August 5, 2011Publication date: December 1, 2011Applicant: KNOPP NEUROSCIENCES, INC.Inventors: Michael E. BOZIK, Thomas PETZINGER, JR., Valentin GRIBKOFF
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Publication number: 20110224268Abstract: Pharmaceutical compositions of R(+) pramipexole and methods of using such compositions for the treatment or prevention of diseases associated with or related to mitochondrial dysfunction or increased oxidative stress are disclosed.Type: ApplicationFiled: February 28, 2011Publication date: September 15, 2011Applicant: Knopp Neurosciences IncInventors: Michael E. Bozik, Gregory T. Hebrank, Thomas Petzinger, JR.
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Patent number: 8017598Abstract: Compositions of predetermined amounts of R(+) pramipexole and S(?) pramipexole and methods of using the same, including for the treatment and prevention of Parkinson's disease, are provided.Type: GrantFiled: May 16, 2007Date of Patent: September 13, 2011Assignee: Knopp Neurosciences, Inc.Inventors: Michael E. Bozik, Thomas Petzinger, Jr., Valentin Gribkoff
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Publication number: 20110190356Abstract: Pharmaceutical compositions of (R)-pramipexole and one or more secondary therapeutic agents such as, for example dopamine agonists, dopaminergic agonists, COMT inhibitors, MOA inhibitors, excitatory amino acid antagonists, growth factors, neurotrophic factors, antioxidants, anti-inflammatory agents, immunomodulators, anti-glutamatergics, ion channel blockers, ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists, heat shock protein inducers/protein disaggregators and downregulators, monoamine oxidase type B (MOAB) inhibitors, multi-target agents, kinase inhibitors, Bcl inducers, histone deacetylase (HDAC) mediators, glial modulators, mitochondrial energy promoting agents, myostatin inhibitors, caspase inhibitors and combinations thereof or those related to mitochondrial dysfunction or increased oxidative stress are disclosed.Type: ApplicationFiled: August 19, 2009Publication date: August 4, 2011Applicant: Knopp Neurosciences Inc.Inventors: Michael E. Bozik, Valentin Gribkoff
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Publication number: 20090054504Abstract: Modified release pharmaceutical compositions (controlled release, sustained release, and/or extended release) of the R-(+) enantiomer of pramipexole (RPPX) and methods of using such compositions for the treatment of neurodegenerative diseases, or those related to mitochondrial dysfunction or increased oxidative stress are disclosed.Type: ApplicationFiled: March 14, 2008Publication date: February 26, 2009Applicant: KNOPP NEUROSCIENCES, INC.Inventors: Michael E. Bozik, Thomas Petzinger, Jr., Valentin Gribkoff
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Publication number: 20090042956Abstract: Pharmaceutical compositions of (R)-pramipexole and methods and kits of using such compositions for the treatment of neurodegenerative diseases, or those related to mitochondrial dysfunction or increased oxidative stress are disclosed.Type: ApplicationFiled: December 14, 2007Publication date: February 12, 2009Applicant: KNOPP NEUROSCIENCES, INC.Inventors: Michael E. Bozik, Thomas Petzinger, JR., Valentin Gribkoff
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Publication number: 20080227985Abstract: Methods for preparing chirally purified substituted 4,5,6,7-tetrahydro-benzothiazole diamines such as, for example, (6R)2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole and purifying a dominant enantiomer of substituted 4,5,6,7-tetrahydro-benzothiazole diamines from entantiomerically enriched mixtures of substituted 4,5,6,7-tetrahydro-benzothiazole diamines are provided herein.Type: ApplicationFiled: March 14, 2008Publication date: September 18, 2008Applicant: KNOPP NEUROSCIENCES, INC.Inventors: Prasad Raje, Rajendrakumar Ruddy Gadikota, Jian-Xie Chen, Olga V. Lapina, John M. McCall
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Publication number: 20080014259Abstract: Compositions of predetermined amounts of R(+) pramipexole and S(?) pramipexole and methods of using the same, including for the treatment and prevention of Parkinson's disease, are provided.Type: ApplicationFiled: May 16, 2007Publication date: January 17, 2008Applicant: KNOPP NEUROSCIENCES, INC.Inventors: Michael Bozik, Thomas Petzinger, Valentin Gribkoff
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Publication number: 20070259930Abstract: Pharmaceutical compositions of R(+) pramipexole and methods of using such compositions for the treatment or prevention of diseases associated with or related to mitochondrial dysfunction or increased oxidative stress are disclosed.Type: ApplicationFiled: April 10, 2007Publication date: November 8, 2007Applicant: KNOPP NEUROSCIENCES, INC.Inventors: Michael Bozik, Gregory Hebrank, Thomas Petzinger