Patents Assigned to Know Bio, LLC
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Patent number: 11813270Abstract: Several embodiments of NO releasing compounds are disclosed. In some embodiments, the structures are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and use of these structures. The compounds may be tailored to release nitric oxide in a controlled manner and can be useful, for example, for treating or preventing microbial infections, or reducing the microbial load of a microbial infection.Type: GrantFiled: December 3, 2021Date of Patent: November 14, 2023Assignee: KNOW BIO, LLCInventors: Drew Folk, Ryan Gerald Anderson, John Kelly Simons, Mona Jasmine Rosales Ahonen, Rebecca Anthouard McDonald
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Patent number: 11752359Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: GrantFiled: August 24, 2021Date of Patent: September 12, 2023Assignee: KNOW Bio, LLCInventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald, James Michael Lay
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Patent number: 11712578Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: GrantFiled: August 24, 2021Date of Patent: August 1, 2023Assignee: KNOW Bio, LLCInventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald, James Michael Lay
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Patent number: 11684798Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: GrantFiled: August 24, 2021Date of Patent: June 27, 2023Assignee: KNOW Bio, LLCInventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald, James Michael Lay
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Patent number: 11654294Abstract: Devices and methods for impinging light on tissue to induce one or more biological effects, and more particularly illumination devices and related methods that may be used for intranasal delivery of irradiation are disclosed. Exemplary illumination devices may include a light guide that is optically coupled with a light source, where the light guide may be configured for insertion along one or more intranasal passageways. In this manner, the light guide may provide irradiation of light to tissues along or near the upper respiratory tract to prevent and/or treat various infections and other tissue conditions thereof. Light guides may include flexible materials with suitable dimensions and/or shapes that allow the light guides to follow variable paths of intranasal passageways during use.Type: GrantFiled: March 15, 2021Date of Patent: May 23, 2023Assignee: KNOW Bio, LLCInventors: Antony Paul van de Ven, Michael John Bergmann
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Patent number: 11617895Abstract: Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.Type: GrantFiled: June 10, 2020Date of Patent: April 4, 2023Assignee: KNOW Bio, LLCInventors: Nathan Stasko, Nicholas William Medendorp, Jr., Gerald H. Negley, Katelyn P. Reighard
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Patent number: 11524173Abstract: Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.Type: GrantFiled: December 10, 2019Date of Patent: December 13, 2022Assignee: KNOW Bio, LLCInventors: Nathan Stasko, Nicholas William Medendorp, Jr., Gerald H. Negley, Katelyn P. Reighard
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Patent number: 11484730Abstract: Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.Type: GrantFiled: December 10, 2019Date of Patent: November 1, 2022Assignee: KNOW Bio, LLCInventors: Nathan Stasko, Nicholas William Medendorp, Jr., Gerald H. Negley, Katelyn P. Reighard
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Patent number: 11400309Abstract: Modulated light therapy devices for treatment of dermatological disorders of the scalp are provided. An exemplary device includes a flexible printed circuit board (FPCB) supporting at least one light emitting device having an emitter height. The FPCB includes multiple interconnected panels and bending regions defined in and between at least some of the interconnected panels as to allow the FPCB to be configured in a concave shape to cover at least a portion of a cranial vertex of the patient. At least one light-transmissive layer proximate to the FPCB is configured to transmit (e.g., incoherent) light emissions generated by at least one light emitting device. At least one standoff is configured to be arranged between the FPCB and the scalp of the patient, wherein the at least one standoff includes a standoff height that exceeds the emitter height.Type: GrantFiled: May 27, 2020Date of Patent: August 2, 2022Assignee: KNOW Bio, LLCInventors: Nicholas William Medendorp, Jr., Gerald H. Negley, Matthew Carl Reynolds, James Michael Lay
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Patent number: 11383095Abstract: Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.Type: GrantFiled: December 10, 2019Date of Patent: July 12, 2022Assignee: KNOW Bio, LLCInventors: Nathan Stasko, Nicholas William Medendorp, Jr., Gerald H. Negley, Katelyn P. Reighard
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Patent number: 11338151Abstract: Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.Type: GrantFiled: December 10, 2019Date of Patent: May 24, 2022Assignee: KNOW Bio, LLCInventors: Nathan Stasko, Nicholas William Medendorp, Jr., Gerald H. Negley, Katelyn P. Reighard
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Patent number: 11147984Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: GrantFiled: December 10, 2020Date of Patent: October 19, 2021Assignee: KNOW Bio, LLCInventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald
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Patent number: 10688315Abstract: Modulated light therapy devices for treatment of dermatological disorders of the scalp are provided. An exemplary device includes a flexible printed circuit board (FPCB) supporting at least one light emitting device having an emitter height. The FPCB includes multiple interconnected panels and bending regions defined in and between at least some of the interconnected panels as to allow the FPCB to be configured in a concave shape to cover at least a portion of a cranial vertex of the patient. At least one light-transmissive layer proximate to the FPCB is configured to transmit (e.g., incoherent) light emissions generated by at least one light emitting device. At least one standoff is configured to be arranged between the FPCB and the scalp of the patient, wherein the at least one standoff includes a standoff height that exceeds the emitter height.Type: GrantFiled: July 28, 2016Date of Patent: June 23, 2020Assignee: Know Bio, LLCInventors: Nicholas William Medendorp, Jr., Gerald H. Negley, Matthew Carl Reynolds, James Michael Lay
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Patent number: D952171Type: GrantFiled: April 27, 2021Date of Patent: May 17, 2022Assignee: KNOW Bio, LLCInventors: David T. Emerson, James Michael Lay, Michael John Bergmann, Thomas Matthew Womble
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Patent number: D952876Type: GrantFiled: November 10, 2020Date of Patent: May 24, 2022Assignee: KNOW Bio, LLCInventors: David T. Emerson, James Michael Lay, Michael John Bergmann, Thomas Matthew Womble
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Patent number: D987094Type: GrantFiled: April 5, 2022Date of Patent: May 23, 2023Assignee: KNOW Bio, LLCInventors: David T. Emerson, James Michael Lay, Michael John Bergmann, Thomas Matthew Womble