Patents Assigned to KNU - Industry Cooperation Foundation
-
Patent number: 10323033Abstract: Provided are an imidazo[1,2-a]pyridine-3-carboxylate derivative and a preparation method thereof, and more particularly, a method of effectively preparing an imidazo[1,2-a]pyridine-3-carboxylate derivative by performing an aza-[3+2] cycloaddition reaction of a pyridine derivative with an ?-diazo oxime ether derivative in the presence of a copper (II) catalyst, and an imidazo[1,2-a]pyridine-3-carboxylate derivative prepared thereby.Type: GrantFiled: June 8, 2018Date of Patent: June 18, 2019Assignee: KNU-INDUSTRY COOPERATION FOUNDATIONInventor: Phil Ho Lee
-
Patent number: 9868775Abstract: Provided is a peptide fragment derived from secreted frizzled protein 5 (Sfrp5), i.e., a peptide fragment selected from the group consisting of the peptides as set forth in SEQ ID NOs: 1 to 9 and a cosmetic composition for skin-whitening and/or inhibiting skin pigmentation comprising the same as an active ingredient. The peptide fragment inhibits melanin formation in melanocytes, thereby having an inhibitory activity against skin pigmentation. Further provided is a reagent for researching or analyzing the inhibition of Wnt signaling pathways comprising the peptide fragment.Type: GrantFiled: November 23, 2015Date of Patent: January 16, 2018Assignees: KNU-INDUSTRY COOPERATION FOUNDATION, SUPADELIXIR INC.Inventors: Jang-Hee Hahn, Dong-Young Lim
-
Publication number: 20170334965Abstract: Provided is a peptide fragment derived from secreted frizzled protein 5 (Sfrp5), i.e., a peptide fragment selected from the group consisting of the peptides as set forth in SEQ ID NOs: 1 to 9 and a cosmetic composition for skin-whitening and/or inhibiting skin pigmentation comprising the same as an active ingredient. The peptide fragment inhibits melanin formation in melanocytes, thereby having an inhibitory activity against skin pigmentation. Further provided is a reagent for researching or analyzing the inhibition of Wnt signaling pathways comprising the peptide fragment.Type: ApplicationFiled: July 31, 2017Publication date: November 23, 2017Applicants: KNU-INDUSTRY COOPERATION FOUNDATION, SUPADELIXIR INC.Inventors: Jang-Hee HAHN, Dong-Young LIM
-
Patent number: 9691601Abstract: A supporting unit is provided. The supporting unit includes a body, an alignment member, at least one sensor, and a controller. The body has a top surface supporting a target object. The alignment member is disposed in the body and adjusts a position of the target object. The sensor senses the position of the target object. The controller controls the alignment member and the sensor member. The alignment member includes a magnet that adjusts the position of the target object according to an electromagnetic force; and a coil that applies the electromagnetic force to the magnet.Type: GrantFiled: May 31, 2016Date of Patent: June 27, 2017Assignees: SAMSUNG ELECTRONICS CO., LTD., KNU-INDUSTRY COOPERATION FOUNDATIONInventors: Sang-Hyun Park, Sangdon Jang, In Bae Chang
-
Patent number: 9670240Abstract: Provided are novel cyclic phosphinate derivatives and a method of preparing the same, and more particularly, cyclic phosphinate derivatives including benzoxaphosphole oxide derivatives and benzoxaphosphorin oxide derivatives, and a method of preparing the same. The cyclic phosphinate derivative according to the present invention may have pharmacological and physiological activities, be used as the basic skeleton of the natural material, and be used in development of a new drug, and synthesis of various medicines. In addition, with the method of preparing a cyclic phosphinate derivative according to the present invention, various cyclic phosphinate derivatives may be prepared with high yield through a simple synthetic process by performing an intramolecular carbon-oxygen coupling reaction on the phosphinic acid derivative in the presence of a palladium (Pd) catalyst, an oxidant, and a base.Type: GrantFiled: October 5, 2016Date of Patent: June 6, 2017Assignee: Knu-Industry Cooperation FoundationInventors: Phil Ho Lee, Seo Hyun Shin, Dong Jin Kang, Da Han Eom, Yea Rin Kim, Yeon Seok Jeong, Won Seok Choi
-
Patent number: 9624286Abstract: Provided is a pharmaceutical or cosmetic composition comprising adiponectin-derived peptide fragments, i.e., the peptides of SEQ ID NOs: 1 to 6 as an active ingredient. The peptides facilitate skin regeneration and moisturization, inhibit skin wrinkle, and have inhibitory activities against allergy and inflammation as well as metastasis of cancer cells.Type: GrantFiled: September 12, 2014Date of Patent: April 18, 2017Assignees: KNU-INDUSTRY COOPERATION FOUNDATION, SUPADELIXIR INC.Inventors: Jang-Hee Hahn, Dong-Young Lim
-
Publication number: 20170073389Abstract: Provided is a peptide fragment derived from secreted frizzled protein 5 (Sfrp5), i.e., a peptide fragment selected from the group consisting of the peptides as set forth in SEQ ID NOs: 1 to 9 and a cosmetic composition for skin-whitening and/or inhibiting skin pigmentation comprising the same as an active ingredient. The peptide fragment inhibits melanin formation in melanocytes, thereby having an inhibitory activity against skin pigmentation. Further provided is a reagent for researching or analyzing the inhibition of Wnt signaling pathways comprising the peptide fragment.Type: ApplicationFiled: November 23, 2015Publication date: March 16, 2017Applicants: KNU-INDUSTRY COOPERATION FOUNDATION, SUPADELIXIR INC.Inventors: Jang-Hee HAHN, Dong-Young LIM
-
Patent number: 9580322Abstract: Disclosed are a method of preparing a negative active material for a rechargeable lithium battery that includes preparing a solution including spherically shaped natural graphite particles and a solvent, ultrasonic wave-treating the solution, and drying the ultrasonic wave-treated solution to prepare graphite modified particles, and a rechargeable lithium battery prepared therefrom.Type: GrantFiled: August 19, 2013Date of Patent: February 28, 2017Assignee: KNU-INDUSTRY COOPERATION FOUNDATIONInventors: Sung-Man Lee, Yoon-Soo Park
-
Publication number: 20170004893Abstract: An apparatus for detecting a position of a control rod includes a control rod driving shaft having an outer circumferential surface on which position information is marked, a mirror configured to reflect the position information, and a detector configured to detect a position of the control rod driving shaft from the position information reflected from the mirror, when the control rod driving shaft moves vertically.Type: ApplicationFiled: June 30, 2016Publication date: January 5, 2017Applicants: KEPCO ENGINEERING & CONSTRUCTION COMPANY, INC., KNU-INDUSTRY COOPERATION FOUNDATIONInventors: In Bae CHANG, Dae Hee LEE, Sang Gyoon JANG, Myoung Goo LEE, Jin Seok PARK, Yong Tae JANG, Chang Kyu CHUNG, Cheol Soo MAENG
-
Publication number: 20160375534Abstract: A supporting unit is provided. The supporting unit includes a body, an alignment member, at least one sensor, and a controller. The body has a top surface supporting a target object. The alignment member is disposed in the body and adjusts a position of the target object. The sensor senses the position of the target object. The controller controls the alignment member and the sensor member. The alignment member includes a magnet that adjusts the position of the target object according to an electromagnetic force; and a coil that applies the electromagnetic force to the magnet.Type: ApplicationFiled: May 31, 2016Publication date: December 29, 2016Applicants: SAMSUNG ELECTRONICS CO., LTD., KNU-INDUSTRY COOPERATION FOUNDATIONInventors: Sang-Hyun PARK, Sangdon JANG, In Bae CHANG
-
Patent number: 9493494Abstract: Provided are a novel phosphinine oxide derivative and a preparation method thereof, and more specifically, the phosphinine oxide derivative includes an oxaphosphinine oxide derivative and an azaphosphinine oxide derivative. The phosphinine oxide derivative according to the present invention may have a pharmacological activity and a physiological activity, and may be used as a basic framework of a natural product and may be used for development of new drug and synthesis of various medical supplies. In addition, according to the preparation method of the phosphinine oxide derivative according to the present invention, various phosphinine oxide derivatives with a high yield may be prepared by a simple synthesis process using an intramolecular annulation between a phosphinic derivative and an alkyne derivative in the presence of a rhodium (Rh) catalyst or a ruthenium (Ru) catalyst and an oxidant.Type: GrantFiled: August 29, 2014Date of Patent: November 15, 2016Assignee: Knu-Industry Cooperation FoundationInventors: Phil Ho Lee, Young Chul Park, In Cheol Jeon, Jung Min Seo, Bo Ram Seo
-
Patent number: 9493528Abstract: Provided are small peptide fragments derived from microphthalmia-associated transcription factor (MITF) and a method for preventing or treating melanoma using the same as an active ingredient. Further provided is a method for skin-whitening and/or for inhibiting skin pigmentation, using the peptide fragments as an active ingredient.Type: GrantFiled: January 7, 2014Date of Patent: November 15, 2016Assignees: SUPADELIXIR INC., KNU-INDUSTRY COOPERATION FOUNDATIONInventors: Kyeong-Han Park, Jang-Hee Hahn, Dong-Young Lim
-
Patent number: 9487547Abstract: Provided are novel cyclic phosphinate derivatives and a method of preparing the same, and more particularly, cyclic phosphinate derivatives including benzoxaphosphole oxide derivatives and benzoxaphosphorin oxide derivatives, and a method of preparing the same. The cyclic phosphinate derivative according to the present invention may have pharmacological and physiological activities, be used as the basic skeleton of the natural material, and be used in development of a new drug, and synthesis of various medicines. In addition, with the method of preparing a cyclic phosphinate derivative according to the present invention, various cyclic phosphinate derivatives may be prepared with high yield through a simple synthetic process by performing an intramolecular carbon-oxygen coupling reaction on the phosphinic acid derivative in the presence of a palladium (Pd) catalyst, an oxidant, and a base.Type: GrantFiled: January 15, 2015Date of Patent: November 8, 2016Assignee: Knu-Industry Cooperation FoundationInventors: Phil Ho Lee, Seo Hyun Shin, Dong Jin Kang, Da Han Eom, Yea Rin Kim, Yeon Seok Jeong, Won Seok Choi
-
Patent number: 9464112Abstract: Provided are small peptide fragments derived from the NF-?B p65 subunit and a pharmaceutical or cosmetic composition comprising the same. The peptides have a NF-?B inhibitory activity, through controlling the transcription-activation of NF-?B. The peptides inhibit the expressions of pro-inflammatory mediators, which are induced by NF-?B, and also inhibit the transmigration of leukocytes, thereby exhibiting an anti-inflammatory activity. Especially, the peptides have excellent inhibitory activities against dermatitis and skin aging. And also, the peptides inhibit base membrane invasion of cancer cells, thereby exhibiting an inhibitory activity against the growth and/or metastasis of cancer cells.Type: GrantFiled: August 20, 2013Date of Patent: October 11, 2016Assignee: KNU-INDUSTRY COOPERATION FOUNDATIONInventors: Jang-Hee Hahn, Chang-Seo Park, In-Young Ko, Byong-Ik Chun, Byoung-Chul Kim
-
Publication number: 20160222077Abstract: Provided is a pharmaceutical or cosmetic composition comprising adiponectin-derived peptide fragments, i.e., the peptides of SEQ ID NOs: 1 to 6 as an active ingredient. The peptides facilitate skin regeneration and moisturization, inhibit skin wrinkle, and have inhibitory activities against allergy and inflammation as well as metastasis of cancer cells.Type: ApplicationFiled: September 12, 2014Publication date: August 4, 2016Applicants: KNU-INDUSTRY COOPERATION FOUNDATION, SUPADELIXIR INC.Inventors: Jang-Hee HAHN, Dong-Young LIM
-
Publication number: 20160097981Abstract: An optical apparatus and a manufacturing method using the optical apparatus are disclosed. The optical apparatus includes a stage supporting a substrate, first optical systems providing a first light onto the substrate, a gantry supporting the first optical systems to transfer them on the stage, and second optical systems disposed between the gantry and the stage and detecting displacement of the first optical systems. Each of the second optical systems includes a beam source generating a second light different with the first light, and sensor arrays for sensing the second light provided to the first optical systems to detect displacement of the first optical systems.Type: ApplicationFiled: September 28, 2015Publication date: April 7, 2016Applicants: KNU-INDUSTRY COOPERATION FOUNDATION, SAMSUNG DISPLAY CO., LTD.Inventors: SANGJOON HONG, JONGJIN LEE, HiKUK LEE, SANGDON JANG, Inbae CHANG
-
Publication number: 20160002308Abstract: The present invention provides small peptide fragments derived from microphthalmia-associated transcription factor (MITF) and a pharmaceutical composition for preventing or treating melanoma comprising the same as an active ingredient. And also, the present invention provides a cosmetic composition for skin-whitening and/or for inhibiting skin pigmentation, comprising the peptide fragments as an active ingredient.Type: ApplicationFiled: January 7, 2014Publication date: January 7, 2016Applicants: SUPADELIXIR INC., KNU-INDUSTRY COOPERATION FOUNDATIONInventors: Kyeong-Han PARK, Jang-Hee HAHN, Dong-Young LIM
-
Patent number: 9200019Abstract: Provided are a novel phosphorus 2-pyrone derivative and a preparation method thereof. The phosphorus 2-pyrone derivative according to the present invention is capable of being efficiently synthesized by treating an alkyl hydrogen alkynylphosphonate derivative and an alkyne derivative with a minimal amount of a gold catalyst.Type: GrantFiled: June 27, 2013Date of Patent: December 1, 2015Assignee: Knu-Industry Cooperation FoundationInventors: Phil Ho Lee, Jun tae Mo, Taekyu Ryu
-
Publication number: 20150252073Abstract: The present invention provides small peptide fragments derived from the NF-?B p65 subunit and a pharmaceutical or cosmetic composition comprising the same. The peptides have a NF-?B inhibitory activity, through controlling the transcription-activation of NF-?B. The peptides inhibit the expressions of pro-inflammatory mediators, which are induced by NF-?B, and also inhibit the transmigration of leukocytes, thereby exhibiting an anti-inflammatory activity. Especially, the peptides have excellent inhibitory activities against dermatitis and skin aging. And also, the peptides inhibit base membrane invasion of cancer cells, thereby exhibiting an inhibitory activity against the growth and/or metastasis of cancer cells.Type: ApplicationFiled: August 20, 2013Publication date: September 10, 2015Applicant: KNU-INDUSTRY COOPERATION FOUNDATIONInventors: Jang-Hee Hahn, Chang-Seo Park, In-Young Ko, Byong-Ik Chun, Byoung-Chul Kim
-
Patent number: 9073956Abstract: Provided are novel dihydro-1H-phosphole 1-oxide derivatives and a preparation method thereof. More particularly, the dihydro-1H-phosphole 1-oxide derivatives include 1,3-dihydro-1H-2,1-oxaphosphole 1-oxide derivatives and 2,3-dihydro-1H-2,1-azaphosphole 1-oxide derivatives. Further, in the preparation method of a dihydro-1H-phosphole 1-oxide derivative according to the present invention, various phosphinine oxide derivatives may be prepared with high yield by a simple synthesis process by reacting a phosphinic derivative and a vinyl derivative with each other in the presence of a rhodium (Rh) catalyst, an oxidant, and a base.Type: GrantFiled: January 13, 2015Date of Patent: July 7, 2015Assignee: KNU-INDUSTRY COOPERATION FOUNDATIONInventors: Phil Ho Lee, Tae Kyu Ryu, Sang June Park