Abstract: Novel 18F-labelled tetrazines are provided which are highly reactive to be effective in vivo, suitable for pretargeted positron emission tomography (PET) and accessible in radiochemical yields (RCYs) which allow access to 18F-labeled tetrazines for clinical applications. The 18F-labelled tetrazines are developed using a Cu-mediated click indirect labelling approach. Only a subset of compounds appeared to be suitable for clinical pretargeted imaging strategies, and a particular compound which includes the use of an 18F-labelled azide synthon having an azide structure with glucose as the linker and a triazole moiety within the linker, appears to be highly suited for clinical pretargeted imaging purposes.

Abstract: A cardiovascular implantable electronic device (CIED) and related method is disclosed. The CIED comprises a first lead for cardiac stimulation; one or more sensors for provision of sensor data; and a processing device comprising a processor, a communication interface and a lead interface. The processor is configured to: obtain sensor data from the one or more sensors; determine a first set of first parameters based on the sensor data; determine a second set of second parameters based on the sensor data; determine a first cardiac event parameter indicative of a probability of a future cardiac event, wherein the first cardiac event parameter is based on one or more parameters of the first set and the second set; determine if one or more transmission criteria are satisfied; and, if so, transmit a first warning signal to an accessory device, the first warning signal being indicative of the first cardiac event parameter.

Abstract: The present invention relates to a process for producing a lignin composition, which process comprises: providing a lignin slurry comprising water and a water miscible organic solvent; subjecting the lignin slurry to extraction at an extraction temperature of less than 100° C. for an extraction time of at least 1 minute to provide an extracted slurry; removing liquid from the extracted slurry to provide an extracted lignin; and suspending the extracted lignin in a polar organic solvent to provide a lignin composition having a dry matter content of at least 30% by weight. The present invention also relates to a lignin composition comprising hardwood Kraft lignin and a polar organic solvent, which composition has a dry matter content of at least 30% by weight. The present invention also relates to use of the lignin composition as a fuel.

Abstract: This disclosure relates to an optical device comprising: a first filter waveguide section having an input for receiving a pump signal, the first filter waveguide section further having an output; an emitter waveguide section having an input coupled to the output of the first filter waveguide section to receive a transmitted pump signal therefrom, the emitter waveguide section supporting at least a first guided lower-order optical mode and a second guided higher-order optical mode, the emitter waveguide section comprising a photon emitter coupled to the first guided mode to emit radiation into the first guided mode and coupled to the second guided mode to allow optical pumping of the photon emitter by pump signal power carried in the second guided mode, the emitter waveguide section further having an output for outputting radiation emitted from the photon emitter; a second filter waveguide section having an input coupled to the output of the emitter waveguide section and having an output, the second filter wav

Abstract: A cardiovascular implantable electronic device (CIED) and related method is disclosed. The CIED comprises a first lead for cardiac stimulation; one or more sensors for provision of sensor data; and a processing device comprising a processor, a communication interface and a lead interface. The the processor is configured to: obtain sensor data from the one or more sensors; determine a first set of first parameters based on the sensor data; determine a second set of second parameters based on the sensor data; determine a first cardiac event parameter indicative of a probability of a future cardiac event, wherein the first cardiac event parameter is based on one or more parameters of the first set and the second set; determine if one or more transmission criteria are satisfied; and, if so, transmit a first warning signal to an accessory device, the first warning signal being indicative of the first cardiac event parameter.

Abstract: The invention relates to a compound according to formula I wherein when R5 is H, and R1 and R2 form a ring system, then said compound is selected from the following compounds of formula II or formula IV or when R2 is H, and R1 and R5 form a ring system, then said compound has formula III.

Abstract: The present invention relates to non-aqueous topical compositions comprising a halogenated salicylanilide and the use of such compositions in the topical treatment or prevention of diseases and infections, particularly conditions caused by Gram-positive bacteria, for example the topical treatment or prevention of skin infections such as acne, atopic dermatitis and impetigo. Also disclosed are methods for preparing the gel composition.

Abstract: A dosage form for application on mucosae for release of at least one active pharmaceutical ingredient, wherein the dosage form includes an adhesive layer, made of fibers, capable of adhering to the mucosae of the human or animal body, a water-repelling backing layer, and at least one intermediate layer positioned between the adhesive layer and the water-repelling backing layer. The active pharmaceutical ingredient(s) are incorporated in the intermediate layer(s) and/or in the adhesive layer.

Abstract: An inhaler or add-on device for an inhaler for dispensing a medicament to be inhaled. The inhaler or add-on device has a housing (H) with an air inlet (A_I), and an air outlet (A_O) for outputting air to be inhaled by a user. The housing (H) defines a flow path (FP) between the air inlet (A_I) and air outlet (A_O), and a passive acoustic element (PAE) is arranged in this flow path (FP) inside the housing (H). The passive acoustic element (PAE) has a structure having one or more structured gaps arranged to be passed by an air flow and it is dimensioned such that air flow passing it will generate sound (S) with pre-determined characteristics depending on the air flow speed. This allows acoustic monitoring of air flow passing the first passive acoustic element (PAE) external to the housing (H) by capturing and processing sound generated.

Abstract: This disclosure relates to an optical device comprising: a first filter waveguide section having an input for receiving a pump signal, the first filter waveguide section further having an output; an emitter waveguide section having an input coupled to the output of the first filter waveguide section to receive a transmitted pump signal therefrom, the emitter waveguide section supporting at least a first guided lower-order optical mode and a second guided higher-order optical mode, the emitter waveguide section comprising a photon emitter coupled to the first guided mode to emit radiation into the first guided mode and coupled to the second guided mode to allow optical pumping of the photon emitter by pump signal power carried in the second guided mode, the emitter waveguide section further having an output for outputting radiation emitted from the photon emitter; a second filter waveguide section having an input coupled to the output of the emitter waveguide section and having an output, the second filter wav

Abstract: A force transducer is disclosed, which is arranged in such a way that, when a force is applied to the force transducer, two output signals from the force transducer are generated, which output signals are representative of the force components in a first plane and in a second plane perpendicular to the first plane, respectively, whereas force components in a third plane perpendicular to the first plane and the second plane do not affect the output signals from the force transducer. Furthermore, a measuring device is disclosed, comprising a handle comprising such a force transducer and a base unit, to which the handle is attached. Even further, a system for measuring muscle stiffness is disclosed, comprising a measuring unit and a processing unit, the measuring unit comprising such a measuring device.

Abstract: The present invention relates to novel tetrazine compounds of formula I, wherein one of R1-R5 is 18F, for use in pretargeted in vivo imaging. The compounds are suitable for use in click chemistry, i.e. reactions that join a targeting molecule and a reporter molecule. The invention further relates to precursors to formula I, wherein one of R1-R5 is SnR3, B(OR)2, B(0H)2. Formula (I).

Abstract: A biofuel composition and a process for the manufacture of a biofuel composition including lignin and ethanol as the main combustible components of the biofuel composition and having total ash below 1% w/w based on total mass of dry matter in the biofuel composition.

Abstract: The invention relates to coherent single photon sources that provide photons with a high degree of indistinguishability. It is a disadvantage of single photon sources based on QDs in nanophotonic structures that, even at low temperatures, acoustic vibrations interact with the QDs to reduce the coherence of the emitted spectrum. The invention uses mechanical clamping of the nanostructure to damp vibrations leading to a weaker QD—phonon coupling and a higher degree of indistinguishability between successively emitted photons. The clamp is mechanically connected to the length of the photonic nanostructure and has a stiffness and a size sufficient to suppress low frequency vibrations (??10 GHz) in a combined structure of the clamp and the nanostructure.

Abstract: A method for the production of a sol-gel based matrix resulting in a sol-gel based matrix with high stability and high porosity. The sol-gel based material may be used for the production of a composite or sensor suitable for monitoring analytes.

Abstract: Disclosed is a device and a method for medical image reconstruction. The method comprises obtaining, image data of a medical scanner; obtaining a noise model for the image data from the medical scanner; obtaining an initial model indicative of expected image data properties; obtaining a mapping, wherein the mapping is indicative of a mapping from the medical scanner; determining a set of candidate images based on the image data, the noise model, the initial model, and the mapping; and determining and outputting a first representation of the image data based on the set of candidate images.

Abstract: Solid lipid nanoparticles (SLNs) and suspensions thereof in an aqueous phase are provided, in which the SLNs have high content of oil-soluble pigment and high stability. A food product, such as a beverage, comprising said SLNs is also provided.

Abstract: A cardiovascular implantable electronic device (CIED) and related method is disclosed. The CIED comprises a first lead for cardiac stimulation; one or more sensors for provision of sensor data; and a processing device comprising a processor, a communication interface and a lead interface. The the processor is configured to: obtain sensor data from the one or more sensors; determine a first set of first parameters based on the sensor data; determine a second set of second parameters based on the sensor data; determine a first cardiac event parameter indicative of a probability of a future cardiac event, wherein the first cardiac event parameter is based on one or more parameters of the first set and the second set; determine if one or more transmission criteria are satisfied; and, if so, transmit a first warning signal to an accessory device, the first warning signal being indicative of the first cardiac event parameter.

Abstract: A method for producing an octaketide derived aromatic compound of interest (e.g. carminic acid), wherein the method comprises (I): heterologous expression of a recombinantly introduced Type III polyketide synthase (PKS) gene encoding an octaketide synthase (OKS) to obtain non-reduced octaketide in vivo within the recombinant host cell and (II): converting in vivo the non-reduced octaketide of step (I) into a C14-C34 aromatic compound of interest (e.g. carminic acid).

Abstract: A biofuel composition and a process for the manufacture of a biofuel composition including lignin and ethanol as the main combustible components of the biofuel composition and having total ash below 1% w/w based on total mass of dry matter in the biofuel composition.