Abstract: A bladeless impeller and a bladeless axial pump having such an impeller, wherein the impeller has at least one rigid body suitable for rotating around at least one axis of rotation, and at least one helical groove located in the body, forming a passage between two parts of the body.

Abstract: Pol ? protein inhibitor compounds are useful for selectively inhibiting the growth of MLH1 mutant/deficient tumor or cancer cells due to a synthetic lethal relationship between MLH1 and Pol ?. The compounds were shown to directly interact with Pol ? and inhibit its biological function and cause cancer cell death and an inhibition of tumor or cancer cell growth in multiple assays.

Abstract: A novel bioresorbable intracranial pressure sensor fabricated using readily available bioresorbable materials which are compatible with standard microfabrication technology is provided. The intracranial pressure sensor can also stay operational for a relevant time scale and can transfer data wirelessly.

Abstract: A three-dimensional (3D) liver organoid obtained through the differentiation of induced pluripotent stem cells (IPSCs) in laboratory culture medium and a production method of the 3D hepatic organoid are provided. The production method includes the following steps: differentiating the IPSCs into a definitive endoderm in a medium containing Activin A, Wnt3a, and R-spo1 factors; adding 5 ng/ml R-spo 1 during IPSC differentiation to increase an amount of EpCAM+endoderm progenitor cells; cell sorting of the EpCAM+endoderm progenitor cells through a fluorescence-activated cell sorting (FACS) method; culturing a sorted EpCAM+endoderm progenitor cells in a 3D Matrigel medium of 37° C., 5% CO2, 95% humidity and 7.2-7.5 pH.

Abstract: The present invention relates to a centrifugal flow pump that is suitable for pumping blood that can be used as a left ventricular assist device (LVAD). The present invention more specifically relates to a centrifugal blood pump (100) for effectuating conveying of blood in between an axial inlet (22) and a tangential outlet (23), said centrifugal blood pump (100) comprising a pumping chamber housing an impeller (3) attached onto a rotating hub (11) centered on an axis of rotation and a magnetic drive means magnetically coupled to said impeller (3) for rotating impeller (3), and said impeller (3) comprising blades (9, 10) having a geometry that is configured to minimize hemolysis and thrombosis in said centrifugal blood pump (100).

Abstract: An anthracene-functionalized dual cross-linked glycan-based hydrogel with reversible crosslinking, a preparation method thereof, and a use thereof for delivery system of bioactive molecules are provided. The pH responsive and dual crosslinked anthracene incorporated glycan-based hydrogel is prepared via a visible light induced photo-polymerization and a UV light induced photo-dimerization using N-vinyl-2-pyrrolidinone as an accelerator, Eosin-Y as a photo-initiator, and Triethanolamine as a co-initiator.

Abstract: A 11-(4-chlorophenyl)-4-(2,3-dihydro-1H-indole-1-carbonyl)-3,11-dimethyl-5,10,dioxatricyclo[7.4.0.0,2,6,]trideca-1,3,6,8-tetraen-13-one compound and related derivatives, as well as the use thereof in a preparation of a medicament for treatment and/or prevention of diseases or disorders associated with a circadian rhythm. The compound is a CRY1-binding small molecule and also a destabilizer of CRY1, and is therefore useful, as pharmaceutical agent, especially in the treatment and/or prevention of disorders associated with the circadian rhythm, including CRY1-mediated diseases such as cancer.

Abstract: A 2-[2-({12,12-dimethyl-4-oxo-6-phenyl-3,11-dioxatricyclo[8.4.0.0,2,7]tetradeca-1,5,7,9-tetraen-8-yl}oxy)acetamido]benzamide compound and related derivatives, as well as the use thereof in the preparation of a medicament for treatment and/or prevention of diseases or disorders associated with the circadian rhythm are provided. The compound of the invention is a CLOCK-binding small molecule and also an inhibitor of CLOCK:BMAL1 interaction, and is therefore useful, as pharmaceutical agent, especially in the treatment and/or prevention of disorders associated with the circadian rhythm.

Abstract: A three dimensional (3D) microfluidic cartridge suitable for reproduction of cells in the 3D microfluidic cartridge and for observing an angiogenesis process is provided. The 3D microfluidic cartridge includes a side area, wherein a height of the side area is greater than a height of central area. With the 3D microfluidic cartridge, a 3D cell culture is carried out, tumor spheroids are formed in the 3D microfluidic cartridge, and angiogenesis potentials of the tumor spheroids are measured. Further, responses of endothelial cells against angiogenic or antiangiogenic effects of various small molecules, drugs, and protein therapeutics are measured in the 3D microfluidic cartridge.

Abstract: A friction force sensing system comprising one interrupter with a blocking extension and one flexible assembly having a fixed end and a free end, longitudinal flexures extending between said fixed end and said free end, said interrupter and said flexible assembly being fixedly connected to each other by a mounting element at the free end of said flexible assembly.

Abstract: A blockchain architecture operating over a skip graph-based P2P overlay to improve a communication and storage efficiency, a convergence to centralization, and consistency problems of existing blockchain solutions is provided. The blockchain architecture provides addressable peers, blocks, and transactions within a network; making the addressable peers, the blocks and transactions efficiently accessible in an on-demand manner by peers using a skip graph lookup operation where no peer is required to store an entire blockchain, and stores a replicated subset of the blocks and transactions and answers queries of other peer on the blocks and transactions. The blockchain architecture discloses a fair blockchain with a uniform chance for participating peers to be involved in a consensus protocol regardless of an influence of the participating peers in a system with an improved consistency governing a deterministic fork-resolving policy.

Abstract: A semi-persistent scheduling method of machine-type communications specifically for cellular devices and a system employing the semi-persistent scheduling method are provided. Three algorithmic methods act in cooperation with allocating smartest and fastest possible incarnations of a resource handling in a cellular network setting, exploiting an inherent periodicity of a machine-to-machine communication taking place; a high priority cluster takes precedence over another cluster, before assigned to Unit Frequency Bands (UFB) with a given width, any device with a set priority according to a quality-of-service requirement allocation of the any device is executed on the UFB.

Abstract: The present invention relates to an implantable self-driven pump for use as a cavopulmonary assist device. The invention comprises an aortic turbine that uses some systemic blood from the left ventricle as an energy source and a venous pump that is coupled magnetically or mechanically to the turbine. The present invention more particularly relates to a cavopulmonary assist device (10) for a total cavopulmonary connection with superior vena cava-pulmonary artery anastomosis and inferior vena cava-pulmonary artery bridging via a conduit (9), said cavopulmonary assist device (10) comprising a pump unit (20) and a turbine unit (30) coupled by a shaft (401).

Abstract: Disclosed are an optical interferometry apparatus for detection of dielectric nanoparticles and a method for enhancing visibility of the nanoparticles. An imaging system for detection of dielectric nanoparticles includes at least one light source for illumination, a detector array or a camera for image capture, an objective lens, a sample substrate and a computing unit. The sample substrate is capable of carrying sub-wavelength particles smaller than the diffraction resolution limit of the imaging system, and the imaging system includes a movable means which moves the sample substrate in the axial direction such that depthwise different images are captured at different axial distances from the sample substrate to the objective lens. The computing unit computes a correlation image using the depth images wherein the sub-wavelength particles become resolvable and appear with higher contrast in the correlation image.

Abstract: A monolithic triaxial dynamometer for machining applications comprising one flexure frame with three flexural arms and three light blocking extensions protruding three different photointerrupter sensors housed in specially designated sensor placement slots situated on the sensor stand, the bottom of which lands on the floor of the external mounting structure, which is aligned and connected with the said top flexure frame using first and third group screw holes, thus bringing together a dynamometer used for force sensing in various industrial applications.

Abstract: Pol ? protein inhibitor compounds are useful for selectively inhibiting the growth of MLH1 mutant/deficient tumor or cancer cells due to a synthetic lethal relationship between MLH1 and Pol ?. The compounds were shown to directly interact with Pol ? and inhibit its biological function and cause cancer cell death and an inhibition of tumor or cancer cell growth in multiple assays.

Abstract: A microfluid thromboelastometry instrument for analyzing a viscosity of a sample fluid is provided. The microfluid thromboelastometry instrument includes a cartridge for measuring changes in the viscosity of a fluid, the cartridge includes an inlet and an outlet, wherein a flow of the fluid is provided through the cartridge between the inlet and the outlet. The cartridge includes at least one micro-pillar having at least one first position, the at least one micro-pillar is capable of bending with a fluid flow, and an amount of bending increases as the viscosity of the fluid increasing and restores to the at least one first position of the at least one micro-pillars in response to viscosity decrease of the fluid. The micro-pillar is fixed to the surface of the cartridge from the root and has a free distal extremity. A displacement of the micro-pillar distal extremity relative to the micro-pillar root is monitored.

Abstract: Near-infrared (NIR) absorbing photosensitizers for imaging and treatment of cancer in a photodynamic therapy (PDT) are provided. Specifically, the NIR photosensitizers are mitochondria targeted and water-soluble, and used as a cytotoxic drug in a photodynamic therapy of the cancer. The NIR photosensitizers are activated with wavelengths of light, wherein the light penetrates through a body not just a skin. Hence the NIR photosensitizers aim to transform PDT from being a specialized treatment to a generally applicable one. PDT is almost completely non-invasive compared to current treatment methods.

Abstract: The present invention relates to oligonucleotide carriers for oligonucleotide delivery to a subject to provide gene therapy. More particularly, the present invention relates to therapeutic nanoparticles for microRNA (miRNA) delivery to a subject. More particularly, the present invention relates to therapeutic nanoparticles wherein miRNA is bindable to biocompatible nanoparticles using natural gene carrier Argonaute (AGO) protein or a variant thereof. Optionally, therapeutic nanoparticles of the present invention additionally contain targeting moieties for targeting therapeutic nanoparticles to cancer cells and/or chemotherapeutic agents. Optionally, biocompatible nanoparticles are trackable nanoparticles, such as superparamagnetic iron oxide nanoparticles (SPION), to provide multifunctional theranostics.

Abstract: A friction force sensing system comprising one interrupter with a blocking extension and one flexible assembly having a fixed end and a free end, longitudinal flexures extending between said fixed end and said free end, said interrupter and said flexible assembly being fixedly connected to each other by a mounting element at the free end of said flexible assembly.